Dmel008064.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanosoma
Gene Symbol
ftz-f1
Assembly
GCA_035042045.1
Location
JAWNLY010000163.1:3888510-3900284[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2 1.7e+04 -9.4 27.4 47 158 24 146 4 198 0.60
2 3 1.4e-19 1.2e-15 57.8 0.3 1 79 326 403 326 458 0.79
3 3 2.3e-72 1.9e-68 231.7 1.2 157 408 529 773 482 775 0.91

Sequence Information

Coding Sequence
ATGTTATTAGAAATGGATCAACAACAGGCGACTGTACAGTTTATATCGTCGCTGAATCTGTCGCCGTTTAGCATGCAACtcgaacaacagcagccagcgaGTCCGGCGCacagcaacactaacaacgctaacaataacagcagcaacaacaacaacagcagcagcagtaatagcaacaacaacaacaacaacgataacgaTACAAATGCATTAAGCAATTCCGATAACGATTACAGTGCATACACGCTGCAACTGGGCagtcatcagcagcaacagcaacactcacatcacacacaccaccagcaacagcaacaacaacaacatcagcatcagcattaccaacagcaacaacaacagaatattgccaacaacaatgcgaatGCAGCGGCGAACCAATTCAATGGTTCCTCCTATtcgtatatatacaatttcgATTCACAGTACATATTCCCGACAGGCTATCAGGAAACGAACTCATCCCATTCGCAGCAAAGTGCAAGTGGAGCTGGCAACGCCGCATCAGCTAGCAACTCTGGCCAGCTCCTAAACAATGGAAGCAGCAGCTCGACAGGTAATAGTTATATGCTGTTGCCACCAGGCGCTGGTGGAACctcagcagctgccgctgcccaTTTGTCCGGCAATGTGGGGGGCAATCCGGCGACGGGCGTTAGCGGAACTGCAGCCGGAGGTGGTCATCATGGCGGCACCAGCGCGAGTTCTGGCGGTGGCGAAGCCATCGACTTTAAGCATCTGTTCGAGGAGTTGTGCCCCGTCTGCGGAGACAAGGTAAGCGGCTATCACTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGCTTTTTTAAGCGCACCgttcaaaacaaaaaggtCTACACTTGCGTGGCGGAGCGGTCCTGCCACATCGACAAGACGCAGCGCAAACGTTGTCCCTATTGTCGATTCCAAAAGTGCCTGGAGGTGGGCATGAAACTAGAGGCGGTTCGAGCGGACAGGATGCGTGGTGGTCGCAATAAATTTGGACCCATGTACAAACGTGACCGGGCGCGAAAACTGCAAGTGATGCGTCAGCGACAATTAGCGCTGCAGGCGTTGCGCAGTTCGATGGGCACGGACATAAAGCCGACGCCTCTATCGCCGGGCTATCAGCAAGCATAtccaaatatgaatattaagcAAGAAATTCAAATACCTCAGGTATCCTCACTCACACAATCGCCAGACTCATCACCCAGCCCCATTGCTATTGCCTTGGGTCAGGTGAATGCAAGCGGTGGCGGAGTGATAGCCACGCCGATCAATGCCGGCAACGGCAATGGGGGCTCTTCacttggcaatggcaacaaccacaccaacaacaacaacaacaacaacaacggcagcagcggTACAGGCAGCGGAAGCGGGGGAGGAGGGGCTGGTGGAGGAGGCTCCAATACTGGTGGGAACAACATCGTCGCCGATGGCCTGCAACGCAAtggaaacagcagcaatagcaatagcaacagtaGCTGCCATGATATCGGCACTGGATCTCTGCAAAACTCAGCCGAAGCGAAATTGTGCTTTGATTCTGGCACACATCCATCGAGCACAGCCGACGCGCTTATTGAGCCACTGAGGGTCTCACCAATGATACGCGAGTTTGTGCAATCGATCGATGATCGAGAATGGCAAACGCAACTTTTTGCCCTACTGCAGAAGCAGACGTACAATCAAGTTGAAGTGGATCTCTTTGAGTTAATGTGTAAAGTGCTTGATCAGAATCTATTCTCACAAGTGGATTGGGCAAGAAACACTGTCTTCTTTAAGGATTTAAAGGTTGACGATCAGATGAAGCTGCTTCAGCATTCTTGGTCTGATATGCTCGTGCTGGATCATTTGCATCATCGCATTCACAACGGTCTGCCCGATGAGACTCAGCTGAATAACGGTCAAGTCTTCAATTTGATGAGTCTCGGCCTACTGGGTGTGCCACAGCTGGGTGACTATTTCAACGAACTGCAGAATAAACTGCAGGAACTGAAGTTCGACATGGGCGACTATGTTTGCATGAAATTCCTAATACTGCTAAATCCAGATGTGCGAGGCATTGTAAACAAGAAGACCGTCTTGGAGGGACATGAGAATGTTCAGGCAGCTCTGCTGGATTACACACTGACATGTTATCCTTCAGTTAATGACAAATTCAGGAGGCTACTGAACATCCTTCCGGAAATTCATGCAATGGCCGCACGGGGCGAGGAACACCTTTACTCAAAACATTGTGCTGGCAGTGCGCCCACACAGACGCTGCTCATGGAGATGTTACATGCTAAGCGGAAAGTGTAA
Protein Sequence
MLLEMDQQQATVQFISSLNLSPFSMQLEQQQPASPAHSNTNNANNNSSNNNNSSSSNSNNNNNNDNDTNALSNSDNDYSAYTLQLGSHQQQQQHSHHTHHQQQQQQQHQHQHYQQQQQQNIANNNANAAANQFNGSSYSYIYNFDSQYIFPTGYQETNSSHSQQSASGAGNAASASNSGQLLNNGSSSSTGNSYMLLPPGAGGTSAAAAAHLSGNVGGNPATGVSGTAAGGGHHGGTSASSGGGEAIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSMGTDIKPTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASGGGVIATPINAGNGNGGSSLGNGNNHTNNNNNNNNGSSGTGSGSGGGGAGGGGSNTGGNNIVADGLQRNGNSSNSNSNSSCHDIGTGSLQNSAEAKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQELKFDMGDYVCMKFLILLNPDVRGIVNKKTVLEGHENVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00485910;
90% Identity
iTF_00508363;
80% Identity
iTF_00543799;