Dmel006853.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanocephala
Gene Symbol
-
Assembly
GCA_037043625.1
Location
JBAMBD010000551.1:1017826-1023129[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0021 0.14 12.6 2.5 2 23 145 166 144 166 0.97
2 13 0.00013 0.0085 16.4 1.3 1 23 409 431 409 431 0.98
3 13 7.1 4.7e+02 1.5 0.8 1 23 437 460 437 460 0.88
4 13 8.8 5.8e+02 1.2 0.3 1 23 489 512 489 512 0.89
5 13 0.004 0.26 11.7 2.1 5 23 813 831 810 831 0.92
6 13 0.045 3 8.4 1.4 1 23 837 860 837 860 0.98
7 13 6.8 4.5e+02 1.6 1.0 2 19 900 918 896 920 0.55
8 13 0.0029 0.19 12.2 0.7 1 23 940 963 940 963 0.97
9 13 0.011 0.72 10.4 0.4 1 23 1106 1129 1106 1129 0.92
10 13 0.00032 0.021 15.2 3.0 1 23 1143 1165 1143 1165 0.98
11 13 0.0015 0.097 13.1 4.0 2 23 1198 1222 1197 1222 0.90
12 13 0.086 5.7 7.5 0.2 1 23 1227 1249 1227 1249 0.96
13 13 0.006 0.4 11.2 1.3 1 23 1255 1278 1255 1278 0.96

Sequence Information

Coding Sequence
ATGGCGCAAAAACGTTTAAAAGCAGCGGACATGgaaatcaattacaaattcaCATGTCGCTGTTGCCTCAAATCCGAGGCGGAATTCTTCAAGCTGGACTCCCTCATCGACTGTGGCAACGATGATGCCagtgacaatgacaatgatgcATCGTCCACAACAAAATTGCCCCTGTTGCGTTTACTGCTCTTCTGCATGCGCACCGAAAATCTGCCCGAGCTGCCGCAATACATTTGCGTGGAATGCCGAAAAAGTTTACAAATTGCCTACTATTTCATCCAGAACGGTTTGCGTGCCCACGAAATATTGTGTCGCAAGTTGTGTCCGGGCAAGCTGCAAGCCAAACCGCGCATCAACGGACAACATTTAGCCCTAAGGCTCGAGGCAAAAGCTGGCGCAGCGTTGCTGGACACGCACAGGGAGAAACCcctaaaatgcaaaatatgcgGTGAGGTTATCCACAATCGCTTGGAGCTGAAACATCATCTACGAATGCATtcagAGTCTCGACACCAGTGTAAATTGTGCAACTTTGTAACGCTGAAGCATCGCCAGCTGCTGGAGCACTATCGCAAATCGCATGGCTTGACAACGGCCCAAATTGAGCATCAGTTGAAAATACGAAGATCGCTGCAGGCGGCTGccagtacaacaacaacaataaaagctatAACAGCTGCATCTACAGAaacgcctgctgctgctgctgctgcagacgaTGATGGTCAGGTGAAGGTGTGTACAATGGAGGACATGGAGCTGCTGATACCCACAGTGTTGACGCCCGAGGATTTCACGCATCCACAACTAGATGCGGATCAATTGCGTGACATTGAACAGCAATTGACGAGCAGCTCGCTGGGATTGGCCAACACCACAGCTGCGTCCACGGAACCGGTGACGGCAAATGCCAGCGGAAGCAGTGCCAATATGAGCATAGGTGCAGAATTTCTGGTCATGCCCGATGGCTCGTTGCAGCAGGTGAATGATGCTGGCGTTGTCTTCGAATATATTGATGATAGTAAAAATGCGgccaacacaacaacaacaacaagcacaacgaCCAATGTAACGCTGGAGAGCCTGTTGAGTGACTCGAAAACCGATTTAACCTATGATGCAATGAACATTGATCTGAGTCCTATGGTTGTCGATAATGCGCTGCCACAGATAACAGTCAAGCCCAAGGGGCGACCAGCGCCAGCGTCTACTGGTGCCCtgaaacacaaatgcaaactgTGTCCCAAAGCATTTCCGACGGTGGCACGCCTCAAATCTCACCAGCTAACGCATAGCCATTTACCTAAATTCTATTGTGATCAGTGCACATTTTATTCTCTGCGCAGCGCCGATCTCATCCAGCATTATACGAGCGAACATAATATATGCGTTAGCGATACGAAAGCTAGTCAAGTGGAGAAGTCACCAATGCTGACGGCAATGTTAACGGATCGCAATCGCATCTTCTCCTGCGATATGTGTCTGTTTGAGACGCCGAGTGGCGGTCAGCTGCGCTTGCATTACAGTGATAAGCATCTCATTGTGCCCAGTGAGATACAGCTGCGTCCCAGCTGGATCAGAGATCAGCAGGATGGCAATGCGAAGCTGAAAAGTGGCGATGCCAATACACAACCAGACATTCCACTGGGCATTAAATATCCAACCATGACGCAGTGTGCTGCAGCCACAATTACAACAACGCCGGCGAAAACAACAAGCATGGTGCAACAGCCGcaggcaataacaacaacaacaacggcagtgACGTCCACGGGTGGCATTAATGTTGTTGTCGATGCCAGCTCATTGTTCtatgcagcaactgctgctgaaaATGTAGGAACAACGGCTGCAATAACGACTGCAACAACgggtgcaacagcaacaacgggtgcaacagcaacaacaacaacgggcgCATCAGCTACAGATTCAAGCACAATTGCAATATTTCCAGAACAATgcctggcaacaacaacaacaacagcaaaagcagcaataacaaatccACAGGAGGCAAGCAATCAGGCAgtgacaacatcaacaacaacagcaacaaatccCAATACTAGCACATTTGGGGATATGCAGGAGTTTATAGATAATACAGATGTGGCAGCTATATGCACAATACCCGCCGACGATATGCCTGTGGATGGCGATGATATCGtaatcgataataataatattagtcTGGATTTTGATGCCGAAAATCTATTTGAGGAATTTGAAGATGTCGAAGTTGGCGAAGAGGTTGACGATGACGACGCTGAGGAGGatgacgaggatgaggatgaggatgatgcGGACAATGATGATGAGAATGATAACAATGATGCGGCTGCCGATCAAAATCTCTTGCTAACcagcgacgatgacgatgtgGATGACTTTGACGACGAACAATCGAAGCATCTGCAGAAACCCTATTGCATCTTTTGCAACAAAAAGTTTACCAGCCAATACAAGTTCGAGAATCATATGTTTGTGCATCGTGGTTTGGCACCCTATCGCTGTGAGCTGTGCACCAATCTGTACAATATGAAACGTCTGCTCATACGACATTATAAAACGGTTCACAAAAAGATGCCCACGCGGGACATGGTGCAGGCCAAGGGCGACAAGGTAGCCGTGCCGTGTACGGCTATCgaaaagataaatataaatgcggACAAAAatCCCTTGCTGATGTGCGCCAAGTGTCCCTTTGAATGTGAGCTGGATGTGGATATgcgcaaacatttaaatgcccATCATGGCATCAACGATGGCGTTTCCATGCATGCCAACGAAGTGTTTATCATACGCAAACTGCCCTATGAATGTCCACGCTGCATTCGTTCATTTGCGGCAAAGCGAACGTTGACACGCCACTTGCAGCGTAGCCATTTGGTGGATACAATCATTGAGATGCAGGCGCTTCAATTGACAACCAGTTCGGCGGCAACGACAACCacagcgacgacaacaaccacattgCCGAACAATGCCAGCGATGGCAATAAGGCCACAGCAAATGCGGTTGTGGAGTCGTCCAATAATGGCAatatcgatgtcgatgtcgatctTGGCGATGGCGGCGATGGAAAATGCGTATCAACGCTTTTTCCAACACCCACGCCTTTTGACTTTGATCTTGACTTCATTGGCAACGTGGCACATGCCACAACGctcaagaacaacaacgatgatAGCTTCAATGTGGCATCTCTGCCTCCGCCCCTACTGTTAAATGGCAGCGATAAATTGCTGACTGCAGCGCTGGAGCCGTCGCCCGTTAAGGATTTGCGTCCACGTCTGCCCCGTACCCCCATCTATGTGTGCAAGCAATGCAATCAAACGTTCGACGAGCTGGCCAAGCTGTTGCAGCACGAGCTGCAGCAACATTCCAGTGGCACGATGTCCACGCCACGCAGCAGCTATCAGCATCAGTGCAAGATCTGTAATGCCTCCTATCGCACTGTGACCCTGCTCAATTATCACATGAAGCGACATGCGCCGGTCAAAGTGCCCTGCAAGGAGTTTCAGGTTAGCACGGAATTGAAGCCCGATCATGTTCAGTCCGATCATCGTGGAAATAGTGGTCCACTCAAGTGTGGCATCGATGGCTGCCGGAAGACCTTCAATTACAAGCATCATTTAAAGCGACATCAGACCGCATCGCATACGCCTGTACAATATATTTGTCCGGAGTGCGGACGCGATATGCTGACCAGTCTGTATCTGAGGAATCACATGTCCATGCACCGGGGCACCCACTCCTACAAGTGCCCCAAGTGCGTGCGCACCTATATGCGCCGTAATCCtTTCCGTCGACATGCGTTGCGGGAGCACAAATGGGAATTGACGGATGCggaaattgataaaatatattgtgaaAATGATTCAACGCCATCAATAATATTGCGCGATTTGCGGTGA
Protein Sequence
MAQKRLKAADMEINYKFTCRCCLKSEAEFFKLDSLIDCGNDDASDNDNDASSTTKLPLLRLLLFCMRTENLPELPQYICVECRKSLQIAYYFIQNGLRAHEILCRKLCPGKLQAKPRINGQHLALRLEAKAGAALLDTHREKPLKCKICGEVIHNRLELKHHLRMHSESRHQCKLCNFVTLKHRQLLEHYRKSHGLTTAQIEHQLKIRRSLQAAASTTTTIKAITAASTETPAAAAAADDDGQVKVCTMEDMELLIPTVLTPEDFTHPQLDADQLRDIEQQLTSSSLGLANTTAASTEPVTANASGSSANMSIGAEFLVMPDGSLQQVNDAGVVFEYIDDSKNAANTTTTTSTTTNVTLESLLSDSKTDLTYDAMNIDLSPMVVDNALPQITVKPKGRPAPASTGALKHKCKLCPKAFPTVARLKSHQLTHSHLPKFYCDQCTFYSLRSADLIQHYTSEHNICVSDTKASQVEKSPMLTAMLTDRNRIFSCDMCLFETPSGGQLRLHYSDKHLIVPSEIQLRPSWIRDQQDGNAKLKSGDANTQPDIPLGIKYPTMTQCAAATITTTPAKTTSMVQQPQAITTTTTAVTSTGGINVVVDASSLFYAATAAENVGTTAAITTATTGATATTGATATTTTGASATDSSTIAIFPEQCLATTTTTAKAAITNPQEASNQAVTTSTTTATNPNTSTFGDMQEFIDNTDVAAICTIPADDMPVDGDDIVIDNNNISLDFDAENLFEEFEDVEVGEEVDDDDAEEDDEDEDEDDADNDDENDNNDAAADQNLLLTSDDDDVDDFDDEQSKHLQKPYCIFCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIRHYKTVHKKMPTRDMVQAKGDKVAVPCTAIEKININADKNPLLMCAKCPFECELDVDMRKHLNAHHGINDGVSMHANEVFIIRKLPYECPRCIRSFAAKRTLTRHLQRSHLVDTIIEMQALQLTTSSAATTTTATTTTTLPNNASDGNKATANAVVESSNNGNIDVDVDLGDGGDGKCVSTLFPTPTPFDFDLDFIGNVAHATTLKNNNDDSFNVASLPPPLLLNGSDKLLTAALEPSPVKDLRPRLPRTPIYVCKQCNQTFDELAKLLQHELQQHSSGTMSTPRSSYQHQCKICNASYRTVTLLNYHMKRHAPVKVPCKEFQVSTELKPDHVQSDHRGNSGPLKCGIDGCRKTFNYKHHLKRHQTASHTPVQYICPECGRDMLTSLYLRNHMSMHRGTHSYKCPKCVRTYMRRNPFRRHALREHKWELTDAEIDKIYCENDSTPSIILRDLR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00557462;
90% Identity
iTF_00518733;
80% Identity
-