Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 3e-06 0.015 15.2 0.1 6 48 70 112 65 115 0.88

2 7 0.0097 50 3.9 0.3 21 45 116 140 110 145 0.85

3 7 0.0076 39 4.3 0.7 17 44 140 167 136 170 0.86

4 7 0.0031 16 5.5 0.3 16 45 167 196 154 199 0.85

5 7 0.0015 7.6 6.5 0.4 18 44 197 223 193 228 0.90

6 7 0.00092 4.8 7.2 0.1 21 44 228 251 224 257 0.89

7 7 0.0061 31 4.6 0.2 21 44 256 279 253 285 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	3e-06	0.015	15.2	0.1	6	48	70	112	65	115	0.88
2	7	0.0097	50	3.9	0.3	21	45	116	140	110	145	0.85
3	7	0.0076	39	4.3	0.7	17	44	140	167	136	170	0.86
4	7	0.0031	16	5.5	0.3	16	45	167	196	154	199	0.85
5	7	0.0015	7.6	6.5	0.4	18	44	197	223	193	228	0.90
6	7	0.00092	4.8	7.2	0.1	21	44	228	251	224	257	0.89
7	7	0.0061	31	4.6	0.2	21	44	256	279	253	285	0.84

Coding Sequence: ATGGCACATACGATAGACGTGGGCTGCGTCAAGGAGGAGCACTGTGAGGCGATTTGCAATATGTTTAAAGCCCAGGATTGGCCACTGACCATGCGACACAGGGACCTAGGTCTGGTTAAGATCGAGCAGGACATGAGCTTTGTGTGGCAAAGCAGCCCGAGTGTCACACTGGACGGCAAGGACCGACAAACAGAGAAGCAGGCCCAGAAAAAATTCCAGCACGGTGCCAAAACGCCATACAGCGGGTCGGCCAGCGAGAAGCCTTTCAAGTGCGCGCACTGCCCCAAGGACTTTGCCACCAGCAGCAATCTCAAGGTGCATCTGACACGCACCCACTCCGGAGATCGCGAGCGCCCGTTTTTGTGCCCCAACTGCCCCAAGTCGTTTGCGAGCAATGATAATCTGCAGAAACATATACGCAGGCATTCGAGCGAGCGCAACCTCAACTGTCCACACTGCCCCAAGGCCTTTGCCACAAAGGATAATCTGCAGAAACATATACGCAGGCATTCGAGCGAGCGCAACCTCATCTGTCCGCATTGTCCCAAGGCATTTGCGACCAACGACAATCTGCAGAAGCACATACGCCGGCACTCGAGCGAGCGCACCTTAAATTGTCCACACTGCCCGAAGGCATTTGCCACCAATGATAATCTGCAGCGGCATATACGTGGTCATACGGGTGAGCGACCCTTCAAGTGTCCCTATTGCCCGAAACCCTTTGCCCAAAACAGAGATCTCAAAGCGCACATCCTAGAGCATACGGGCGAGAAGCCCTTTAAGTGTCCACACTGCCCCAAGGCGTGCGTACGCAGCGAGGGCCTCAAGAAACACATACTGCGCCTGCACAAGGACATCGAACCCGAGCAACGACTGACGGCGACCAAGCAATGGCCAACGGGCGACCCAAACGGCAGAGTCTTTATGTACAAATACGATCTAACCAAACACACACGAATGCCCACCGGCGAGGCGTAA
Protein Sequence: MAHTIDVGCVKEEHCEAICNMFKAQDWPLTMRHRDLGLVKIEQDMSFVWQSSPSVTLDGKDRQTEKQAQKKFQHGAKTPYSGSASEKPFKCAHCPKDFATSSNLKVHLTRTHSGDRERPFLCPNCPKSFASNDNLQKHIRRHSSERNLNCPHCPKAFATKDNLQKHIRRHSSERNLICPHCPKAFATNDNLQKHIRRHSSERTLNCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHILRLHKDIEPEQRLTATKQWPTGDPNGRVFMYKYDLTKHTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2