Dlac007455.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila lacicola
Gene Symbol
RHOBTB1
Assembly
GCA_035045355.1
Location
JAWNPB010000133.1:17693757-17697153[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 7.7e-09 1.9e-06 28.1 0.0 3 45 259 302 257 327 0.79
2 3 3.6e-07 9e-05 22.7 0.0 50 102 395 446 374 451 0.82
3 3 7.7e-17 1.9e-14 53.8 0.0 8 103 480 574 475 581 0.92

Sequence Information

Coding Sequence
ATGCCGAAAATGGACAACGAGCAGCCACATCAGGAGCTGGTCAAGTGCGTGCTGGTTGGTGACACTGCCGTGGGAAAGACGCGCCTGATATGCGCCAGGGCTTGCAACAAGCATGTGTCGCTGTCGCAGCTGCTGTCCACGCACGTGCCGACCGTGTGGGCGATCGATCAGTATCGCATTTACAAAGACGTTCTTGAACGCTCTTGGGAAGTGGTGGATGGGGTTAATGTCTCCTTGCGTTTGTGGGACACCTTCGGGGATCATGACAAGGATCGTCGCTTTGCCTACGGCAGATCTGATGTAGTACTCTTGTGTTTCTCCATTGCGAGCCCGATCTCGTTGCGCAATTGCAAAGTAATGTGGTATCCTGAAATACGTCGTTTCTGTCCAGATGTGCCCGTCGTGCTAGTCGGCTGCAAAAATGACCTGCGTTATATGTACCGCGATGAGAACTATTTGTCTTACTTTGGCGAAAAGGGCACCTTTGTACGAGCGGCCTTAAAGAGCGATTTGGTCATGCCGGATGAAGCGCGCGCCGTTGCAAAGGAACTGGGCGTTAGCTATTATGAGACCAGCGTCTTCACGTACTTTGGCGTCAACGAGGTGTTTGAAAATGCGATTCGATCTTCACTTATTGCGCGCCGACAGCAGCGATTTTGGATGACAAACCTGAAAAAGGTGCAAAAGCCGTTGCTGCAGGCACCATTCCGACCACCCAAACCACCACCACCTGAGGTTACCGTCATGGTCGGCCATTACCGCCAGGATATTTACAATATGTTTCTTTCGCAAGCCTATGCCGACCTTATTTTGGTGGTCGGCGGAACCAAGTTTGCGGTGCACAGATTTATGCTTGCCGCGGCATCTGGCATTTTCCAACGCATCCTCAACACTGAGTTGACAGACATGGGTGGCCGAAGCAGCAGTGAGTCGAGCATGGTCAGCTCAACGTTTGGTGAGGCGACCATAGCCGACTTCAACGATGACACAGAATATCTCATACGCTACGAATCACGCACACAACGCATGTGGGAACATTTAAAGCGACGCTCCAGCTATCAAGCTTTACCATTGGTGGAGTCAAAACGCTCCGGTGATTTACATAAGGAGCTGCATCATCCAGTGCTGCAGAGCCTACGCCTAGTGCAAATGGAGAATCAACGCGGCGTCAGCTCTATCCAAACGATTGTTACTCTAAGCAAACTTGTCTCACCCCAGGCCCTGCACCAATGCCTAAGGTTCATTTATACTGGCGCTATTGACAAGGATTGCAGTAATCTGCAGGAAATAAGAGATGCTGCCGATTTATTAGAACTGCCGCAATTAACCATGTTACTTTCCAAGCCACAAAGCCTCATCGAGAGTCCCAGTGATGAACCTAATCCCCACATTTGTCTTCGCATAAAGGAGAGCATGGAAAGGCATTGCATTGGAGACGGTTGCTTCAGCGATGTTACCTTTGAACTGGACGACGGCTTGATGAAGGCACATCGGGCTGTTTTAGTGGGACGCTGCGATGTTATGCGCGCCATGCTCCTGGGCGACTTTCGCGAGGCACATTCTAATGTGaTTGTTTTCCCTGGCGTTACTATTTATACATTCCATAAGCTGCTGTGCTATTTGTACACTGATCAAATTCCGCCCATCTCAGCGGTTAAATGCCTCAATTTGCTGGAATTGGCCAACCGTTTGTGCCTGCCGCGCCTTATCAATCTGATTGAGTGTCGCGTTATTGAAGATCTCACAATTATTTCACAAAACGAAACCAATGAAACGGTCGATCATTGCCTAAAGTTGCTGGAGCCAGTCAAGTTGCACAATGCCCATCAGTTGGCCGAATGGTGTATGTCGTATCTGTGCGTCAATTACAACGTTATCTGTAAGTTTTCACTTAAGGGCTTGAAAGCACTGCATCAGGATAATCAGGAGTATTTGCGCGAGCATCGATGGCCACCAGTTTGGTATCTGAAGGATTACGATTACTATCAGCGCTGCATCAATGAGCTGAACAAGGAGCTAAAGCTAAAAAGCACACGGCGTGATTTCCCAAGCGATGACGAAGGCTGTCTGTGCTTTTCCGGAGTGTTCTCTTGCTGGCTGCTAGGTAAATCAAAGCGGAACGGTGTCGTCAGCGCCAGCGGTCCCAATGGAGAGAGCAACGGAACAACGGCCGAGAATCAAATATTCAACAGCACGGCCAACTCAATGAACCACATCGACCTGGAGGCTGACATCGATCTGAATCTCTGA
Protein Sequence
MPKMDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIASPISLRNCKVMWYPEIRRFCPDVPVVLVGCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMPDEARAVAKELGVSYYETSVFTYFGVNEVFENAIRSSLIARRQQRFWMTNLKKVQKPLLQAPFRPPKPPPPEVTVMVGHYRQDIYNMFLSQAYADLILVVGGTKFAVHRFMLAAASGIFQRILNTELTDMGGRSSSESSMVSSTFGEATIADFNDDTEYLIRYESRTQRMWEHLKRRSSYQALPLVESKRSGDLHKELHHPVLQSLRLVQMENQRGVSSIQTIVTLSKLVSPQALHQCLRFIYTGAIDKDCSNLQEIRDAADLLELPQLTMLLSKPQSLIESPSDEPNPHICLRIKESMERHCIGDGCFSDVTFELDDGLMKAHRAVLVGRCDVMRAMLLGDFREAHSNVIVFPGVTIYTFHKLLCYLYTDQIPPISAVKCLNLLELANRLCLPRLINLIECRVIEDLTIISQNETNETVDHCLKLLEPVKLHNAHQLAEWCMSYLCVNYNVICKFSLKGLKALHQDNQEYLREHRWPPVWYLKDYDYYQRCINELNKELKLKSTRRDFPSDDEGCLCFSGVFSCWLLGKSKRNGVVSASGPNGESNGTTAENQIFNSTANSMNHIDLEADIDLNL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00339220;
90% Identity
iTF_00616963; iTF_00550949; iTF_00588902; iTF_00475275; iTF_00526639; iTF_00534639; iTF_00490838; iTF_00506171; iTF_00563232; iTF_01356194; iTF_00832231; iTF_00901560; iTF_01321990; iTF_01320529; iTF_01324187; iTF_00549607; iTF_00473122; iTF_00516324; iTF_00554440; iTF_00582314; iTF_00476683; iTF_00540427; iTF_00493708; iTF_00512780; iTF_00586735; iTF_00532432; iTF_00568311; iTF_00546714; iTF_00551645; iTF_00599647; iTF_00545303; iTF_00573377; iTF_00544552; iTF_00509872; iTF_00559545; iTF_00587464; iTF_00595308; iTF_00553779; iTF_00472418; iTF_00537571; iTF_00478786; iTF_00589602; iTF_00528867; iTF_00509157; iTF_00523014; iTF_00614246; iTF_00533863; iTF_00508392; iTF_00601864; iTF_00556585; iTF_00598217; iTF_00586026; iTF_00567595; iTF_00569035; iTF_00585261; iTF_00803661; iTF_00538286; iTF_00510607; iTF_00495920; iTF_00520690; iTF_00470932; iTF_00506932; iTF_00608501; iTF_00519223; iTF_00547415; iTF_00557975; iTF_01323448; iTF_00541818; iTF_00610715; iTF_00583740; iTF_00802909; iTF_00805247; iTF_00562528; iTF_00575648; iTF_00584478; iTF_00493013; iTF_01556919; iTF_01549630; iTF_01552513; iTF_01554024; iTF_00579338; iTF_01559819; iTF_01553293; iTF_01554765; iTF_01551790; iTF_01555470; iTF_01551058; iTF_01548917; iTF_01557621; iTF_01558357; iTF_01559098; iTF_01550335; iTF_01556186; iTF_01570299; iTF_00806030; iTF_00561117; iTF_01325727; iTF_00518497; iTF_00566849; iTF_00542498; iTF_01321250; iTF_00501860; iTF_00521412; iTF_00511333; iTF_00558725; iTF_00564709; iTF_00593158; iTF_00497447; iTF_00583017; iTF_01326473; iTF_00535370; iTF_01324971; iTF_00528108; iTF_00500365; iTF_00552365; iTF_00597421; iTF_00513518; iTF_00557262; iTF_00607120; iTF_01327953; iTF_00496658; iTF_00530323; iTF_00482292; iTF_00498932; iTF_00522228; iTF_00570452; iTF_00576404; iTF_00517045; iTF_00609941; iTF_00560342; iTF_00619894; iTF_00499640; iTF_00514233; iTF_01327226; iTF_00485915; iTF_00574107; iTF_01322715; iTF_00543804; iTF_00577116; iTF_00595996; iTF_00616252; iTF_00548861; iTF_00498207; iTF_00495168; iTF_00525184; iTF_00519976; iTF_00572657; iTF_00598937; iTF_00553092;
80% Identity
-