Dlac009729.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila lacicola
Gene Symbol
-
Assembly
GCA_035045355.1
Location
JAWNPB010000148.1:23699421-23704101[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.2e-14 2.5e-11 43.1 0.0 8 74 393 455 387 457 0.88

Sequence Information

Coding Sequence
ATGAGTTCGCCAGACGACGCCTTTGACGGAGCCAACAGCCCCCGTTTTAAGAAGCAACTGAGAGAATCATCGAGCCTTAGCATTTGTAGCGATGATTCTGTGCCTGGTAACAGTGGCTCCAACCATTCGGCTGATATGGGCAAGTCAGCAGGCAATGAACTGCAGACCAATAAAATCAACAGGCAGAACTCTGTCGAAAATGACTCTGATATCTCACAGCATGCGGAGCAGTTAAATGCCGAGCAGAATGCTGAAACGGCAGGCAGTCGCAAGGCCAAAAAGCGTAAGGCCAAGAGAGCCAAGCAACGCCGGGGCTCAAAGGAAGTAGCTTTGATGGGCTGGAGCGGACCCTTTCCCAATCTCTCACCCACCCATAGTCTGGAGAGTAGCTCGGACGTGGATCAGCAGcagctgcccacTGACCTAAAGGCAATCTGTGCCACTGGGCTGAGCATCTTTCCCAGAGAGGACAAGAAGGAGCAGCGACCGCCGCtgtcatcatcgtcgtcttCTGATTCTACTTCCTTCTCGCCAGTTTCCCAACTTAAAACGCctgcgacaacgacaacagcatgTTTTACACTTACAACAAATTCGACTACTTCAAGTCCAAAGTCTACGCagacaaccaacaacaacaacgtcaacaacaacgacaccaATTCAGCCTCAATGTCAATTGCAACAAGTTGTCCTCGTTCAGAACCATCATCAGAGCcagaatcagaatcagaaCCACAAGCTGATGTAGCAAAGCAGACAGTCAAGCATTCAAATGAACGGCCCTCCACTGCCGCCACTGGTATTGATACCGTCGCAAATTTGGACGCTGTTGAGGACTCAAATGCCTCTTTTGGCTCATTGAAAAGCAGAAGCTCGCGTAAACGTGTCACTTCCAATAGAAGTTCAGCCGACGGACAGCAGAATGAATCAAAACGAACCAAGCCATCAGAGCAGGATAATGGCTGCAGCTTGCGGACTCGATCCAAGTCGTTGCATGATCCGAATCCGGATGTGCCGCCGCGCACCCCACGTGCGCGTAGCATCTGCCCCGCCGCCATGCTCAATCAAAATGAGACTGCAGAGCAGACCCCCCCACCCAGCAGTGAAACAAAGACCCCCGCTCGCCGTCGCTCGGTCGCTGCATTTAAGCTGCATCCGACTGATGAATTCTATCGCTTGCCCTTCAAGTACGGCTGGAAACGTGAGCTGGTCCTGCGTAGTAGTGCATCCTTGTCGCGTCAGCGGGGTGACGTTATATTCATATCGCCGGGGGGCAAGAAGCTGCGCTCCCGCGAGGACATCGTTCCGCTGCTGAATGGCGAGTTGACCATCGATCATTTCTGCTTTCAGCGCCAAATGCAGCAGGTCGGCGAGGAGTACGAGACGGTGCGTCAGGCACAGCCTGCCCCGTTGCGTCGGAAATCCTTAGCTGtcgccaagcagcagcaacagttggcCAACGTCAACAACCAACAACTGCCGCCAGTGCCTGCACCCGTGTCTGGCAAGCGTGTGCCTAAGCCTAAGGTTCCCAAGGGCGCTAGCCCTCCGCCTGAGGGTTGGACTTCCACCATGGCCGTTAAGGGAAATGCTCGCGTGTTGGCAGCTAGCAATTGTAACACCAGCGGCGGCCCCGGCTCTGGAGCTGGCAACAGCGCTCGCAAACGAAGCAGCAACCAGACAAAGCAACCATCCAAGCCAGCACCAGATCCAACTGTGCAGGCAAATATTCAACTCCAGTCAGGTAAAGGCAAGACGATGATCTGTGTGTATTGCCTAAAGTTAATCAATGAGAAGCAGCAGGCCTACCCCGTTGGAACCGCCAGTGTCAACAGCTACATCTGTATGCAATGTGTCAAACCCAGTAGCAAAGCTGCAAATGCCAATTTACAGCAAACCGCTAAAGGACTAACACTAACGGAACATGGACCTGCCAACGGCGATAAGGAGCAAGACTTGATTGATGAGAATCTATGCACTGATACCAAAGCTTCTGCCAGTGTGGATGCTGACAaaaatacgaatacgaatgcAGAGGTCGAcgccaatggcaatggcaatggcaatggcggGCTACTGGAAATTGGTGGAGAGATTGAACTGCCGGGCGCGCTGCCGCCGGACCAGTTGCTCAGCGATGAGGCTCCTGGAAGTCGTGCCGGTAACAAGATCACGCCCAAGCCACTGGAAGTCGTTGTCATTAACGGTCGCAAGGCTCTGGCTATTGCTGGCGAGCCGCCATGTCCGCGTTTACAAGTCGTGCCACGCGAACCGGACTTGGagatttatgaaaaatattttcttaagcGCAACTGCACGGCTAAGGAGAAGCGTCAAAATTTCGTTGAATGCATTTCTGCTGGCAACTTAAGCTGCCAGGTGATGTCGGCTGTTATGAAGACACTGGATTTGCACGATCGTGTGCGAATGTCAAACGTATGCAAGACATGGTCGATGATTTCCCGCGATCGTAGCGTGTGGCGCACATTAAAGCTGCGTGACACGCTTATAACTAACTGGTTGTTCCTTTTGCGTGATATGGTGCGTTATCGCACCCGCGAACTGGATATGATGGGGGTCAAAATGACTAATCCCAAGATGCGCATGGAGGGAGATTTGCGTGTGCTAAAAGCATTGCGCATTCTGCGCACTGATGCTTGCGAGGCGGAATTTATCCAGTCAGTTATTAAATGTATACCACGTCTGCTGGAGCTGCGCACCACATGCACCAGTCGTGCACTCAGCCTGGCTAATATGAAGAAGATGTTGGAATTACGCGTGCTGCGCATTCGCATGATAGAGCCCAAGGCCGGCATCTTTTCGTTGCAGCCGCTGCAAAATTTAGAACAATTGAGGGAGCTAAGTTTACGCGGCATTAACAACATGGCACAGCTggagctgttgcagctgcagggATTGAAACAGCTCGAAACGCTTGTGTTAGGCTCCTGTCGTGGTATGAAAGTTACCACGTTTGGGCAGCAAGTGCTACCGAGTCTGAAGCGTCTTCGCCACTTGCGCCTAGAAAACCACCACAGCAATCGCTCATTTAATATCAACGAGATTATGGAAGGCCTCGCCGCCGGCGGCAGTGTAAAACGTGTCGAGCTCATTAATGTCAACGTGGATGCAGAACTTAGCCGTCAGTTGGCAGCTTGTAAATCGGTCCAGGAGCTACTGCTCATGCCAAACTTCCATAATAATACGGCCTATATGATGTGTTACATTATGCAGGCCATCAATGAAAACAGCGAACAGCTCAATGTATTCCGTCTGGGTCTTACTTACGAACTGCTGAGTGTCACGCGTGCGTTGGCTATGAACCAGGAGAAAGACTGTATACCGGTCGCACTGCCGATACCAGGTGTGCCTGACAATGATATACTAAATGAGTCCGATGAGCCAATCGCCTATTTGCCGGTGGATCGCCTGGAATCCATTCTACACCACATGATGCCTCAGGCCTGGCTAACAGTCGCCAAGGTTTCCCAGAGCGAGACAACCAATCTTAAATTCCTTCCGGCTTCACCGAATGACACGTCTGGAATTTCGCATGATTAA
Protein Sequence
MSSPDDAFDGANSPRFKKQLRESSSLSICSDDSVPGNSGSNHSADMGKSAGNELQTNKINRQNSVENDSDISQHAEQLNAEQNAETAGSRKAKKRKAKRAKQRRGSKEVALMGWSGPFPNLSPTHSLESSSDVDQQQLPTDLKAICATGLSIFPREDKKEQRPPLSSSSSSDSTSFSPVSQLKTPATTTTACFTLTTNSTTSSPKSTQTTNNNNVNNNDTNSASMSIATSCPRSEPSSEPESESEPQADVAKQTVKHSNERPSTAATGIDTVANLDAVEDSNASFGSLKSRSSRKRVTSNRSSADGQQNESKRTKPSEQDNGCSLRTRSKSLHDPNPDVPPRTPRARSICPAAMLNQNETAEQTPPPSSETKTPARRRSVAAFKLHPTDEFYRLPFKYGWKRELVLRSSASLSRQRGDVIFISPGGKKLRSREDIVPLLNGELTIDHFCFQRQMQQVGEEYETVRQAQPAPLRRKSLAVAKQQQQLANVNNQQLPPVPAPVSGKRVPKPKVPKGASPPPEGWTSTMAVKGNARVLAASNCNTSGGPGSGAGNSARKRSSNQTKQPSKPAPDPTVQANIQLQSGKGKTMICVYCLKLINEKQQAYPVGTASVNSYICMQCVKPSSKAANANLQQTAKGLTLTEHGPANGDKEQDLIDENLCTDTKASASVDADKNTNTNAEVDANGNGNGNGGLLEIGGEIELPGALPPDQLLSDEAPGSRAGNKITPKPLEVVVINGRKALAIAGEPPCPRLQVVPREPDLEIYEKYFLKRNCTAKEKRQNFVECISAGNLSCQVMSAVMKTLDLHDRVRMSNVCKTWSMISRDRSVWRTLKLRDTLITNWLFLLRDMVRYRTRELDMMGVKMTNPKMRMEGDLRVLKALRILRTDACEAEFIQSVIKCIPRLLELRTTCTSRALSLANMKKMLELRVLRIRMIEPKAGIFSLQPLQNLEQLRELSLRGINNMAQLELLQLQGLKQLETLVLGSCRGMKVTTFGQQVLPSLKRLRHLRLENHHSNRSFNINEIMEGLAAGGSVKRVELINVNVDAELSRQLAACKSVQELLLMPNFHNNTAYMMCYIMQAINENSEQLNVFRLGLTYELLSVTRALAMNQEKDCIPVALPIPGVPDNDILNESDEPIAYLPVDRLESILHHMMPQAWLTVAKVSQSETTNLKFLPASPNDTSGISHD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00550889;
90% Identity
iTF_00616897; iTF_00563170; iTF_00526569; iTF_00550889; iTF_00475211; iTF_00490773; iTF_00506103; iTF_00534573;
80% Identity
-