Basic Information

Insect: Drosophila americana
Gene Symbol: -
Assembly: GCA_018152915.1
Location: JAECXQ010000464.1:2752387-2757061[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 6.5e-15 1.9e-11 43.1 0.0 8 74 392 454 386 456 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	6.5e-15	1.9e-11	43.1	0.0	8	74	392	454	386	456	0.88

Sequence Information

Coding Sequence: ATGAGTTCGCCAGACGACGCCTTTGACGGAGCCAACAGCCCCCGTTTAAAGAAGCAGCTGAGGGAAACGTCGAGCCTTAGCATCTCTAGCGATGATTCTGTGCCTGGTAACAACGATGGCTCCAACCATTCGGCTGATGTGGGCAAGTCCAAGTCAGAAGGCAATGAACTGAAGACCAATACAATCAACACGCAAAACTCTGTCGAAAATGAGTCTGATATGTCACAGCATGCGGAGCAGGAGCAGTTCAATTCCGAACAGAGTGGCAGTCGCAAGGCCAAAAGGCGCAAGGCCAAAAGAGCCAAGCAACGCCGTGACTCAAAGGAAGTAGCTTTGATGGGTTGGAGCGGACCCTTTCCTAATCTCTCACCCACCCATAGTCTGGAGAGTAGCTCGGACGTGGATCAGCAGCAGCTGCCCACTGACCTAAAGGCAATCTGTGCCACTGGGCTGAGCATCTTTCCCAGAGAGGACAAGGAGCAGCGGCCGCCGCTGTCATCATCGTCGTCTTCTGATTCTACTTCCTTCTCGCCAGTTTCCCAACTTAAAACGCCTGCAACAACGACAACAACATGTTTTACACTTACAACAAATTCGACTACTTCAAGTCCAAAGTCTACGCAGACAACCAACAACAACGTCAACAACAACGATACCAATTCAGCCTCAATGTCAATTGCAACCAGTTGTCCTCGTTCAGAACCATCATCAGAGCCAGAATCAGAATCAGAACCACAAGCTGATGTAGCAAAGCAGACAGTGAAGCATTTAAATGAACGGCCCTCCAGTGCCGCCGCTGGTATTGAAACCGTCGCAAATTTAGACGCTGTTGAGGACTCAAATGCCTCTTTTGGCTCATTGAAAAGCAGAAGCTCGCGAAAACGTGGCACTTCCAATAGAAGTTCAGCCGATGGACAACAGAATGAATCCAAACGAACCAAGCCAACAGAGCAGGATAATAATGGCTGCAGTTTGCGCACTCGATCCAAGTCGTTGCATGATCCGAATCCGGATGTGCCGCCGCGCACCCCACGTGCGCGTAGCATCTGCCCCGCCACCATGCTCAGTCAAAATGAGCCTGCAGAGCAGACCCCACCCAGCAATGAAACAAAGACCCCCGCTCGCCGTCGGTCGGTCGCTACATTTAAGCTGCATCCGACTGATGAATTCTATCGCTTGCCCTTTAAGTACGGCTGGAAACGTGAACTGGTCCTGCGTAGTAGTGCATCCTTGTCGCGTCAGCGGGGTGACGTTATATTCATATCGCCGGGGGGCAAGAAGCTGCGCTCCCGCGAGGACATCGTTCCGCTGCTGAATGGCGAGTTGACCATCGATCATTTCTGCTTTCAGCGCCAAATGCAGCAGGTCGGCGAGGAGTTCGAGACGGTGCGTCAGGCACAGCCTGCCCCGTTGCGTCGGAAATCCTTAGCTGTCGCCAAGCAGCAGCAACAGTTAGCCAACGTCAACAACCAACAACTCCCGCCAGTGCCTGCACCCGTGTCTGGTAAGCGTGTGCCCAAGCCTAAGGTTCCCAAAGGCGCTAGCCCTCCGCCTGAGGGTTGGACTTCCACCATGGCGGTTAAGGGAAATGCTCGCGTGTTGGCAGCTAGCAATGGTAATACCAGCGGCGGCCCCGGCTCTGGAGCTGGAAACAGCGCTCGCAAAAGAAGCAGCAACCAGGCAAAGCAACCAGCTAAGCCAGCACCAGATCCAACTGTGCAGGCAAATATTCAACCCCAGTCAGGTAAAGGCAAGACGATGATCTGTGTGTATTGCCTTAAGCTAATCAATGAGAAGCAGCAGGCCTATCCCGTCGGAACCGCCAGTGTCAACAGCTACATCTGTATGCAATGTGTTAAACCCAGTAGCAAAGCCAATTTGCAGCAGGCCGCTAAAGGACTACCAGCGGAACAGGGACCTACCAACGGCACCAAGAAGCAAGACTCGATTGATGAGAATCTATGCACTGATACCAAAGCTTCTGCCAGTGTGGACGCTGACAAAAATATGAATGCAGACGTCGACGCCAATGGCAATGGCAATGGCGGCCTGCTAGAAATTGGTGGAGAGATTGAACTGCCGGGCGCACTGCCGCCGGACCAGTTGCTCAGCGATGAGGTTCCTGCAAGTCGTGCCGGTAACAAGATCACGCCCAAGCCACTGGAAGTCGTTGTCATTAACGGTCGCAAGGCTCTGGCTATTGCTGGCGAGCCGCCGTGTCCGCGTTTACAAGTCTTGCCACGCGAACCGGACTTGGAGATTTATGAAAAATATTTTCTCAAGCGCAACTGCACGGCTAAGGAGAAGCGTCAAAATTTCGTTGAATGCATTTCTGCTGGCAACTTAAGCTGCCAGGTGATGTCGGCTGTTATGAAGACACTGGATTTGCACGATCGTGTGCGTATGTCAAACGTATGCAAGACGTGGTCGATGATTGCCCGCGACCGTAGCGTGTGGCGCACATTAAAGCTGCGTGACACGCTTATAACGAACTGGTTGTTCCTTTTGCGAGATATGGTACGATATCGCACCCGCGAACTGGATATGATGGGGGTCAAAATGACTAATCCCAAGATGCGCCTGGAGGGAGATTTGCGTGTGCTAAAAGCATTGCGCGTTCTGCGCACTGATGCTTGCGAGGCGGAATTTATCCAGTCAGTTATTAAATGTATACCACGCCTGCTGGAGCTGCGTACCACATGCACCAGTCGTGCACTCAGCCTAGCTAGTATGAAGAAGATGTTGGAATTGCGCGTGCTGCGCATTCGCATGATAGAGCCCAAGGCCGGCATCTTTTCGTTGCAGCCGCTGCAAAATTTAGAACAATTGAGGGAGCTGAGTCTACGCGGCATTAACAACATGGCGCAGCTGGAGCTGTTGCAGCTGCAGGGATTGAAACTGCTCGAGACGCTTGTGTTAGGCTCCTGTCGCGGTATGAAGGCTGCGACGTTTGGGCAGCAAGTGCTACCGAGACTGAAGCGTCTTCGCCACCTGCGCCTAGAAAACCACCACAGCAATCGCTCCTTTAATATCAACGAGATCATGGAAGGCATCTCCGCAGGCGGCAGTGTAAAACGTGTCGAGCTCATCAATGTCAACGTGGATGCAGAACTTAGCCGTCAGTTGGCAGCTTGTAAATCGGTCCAGGAGCTACTGCTCATGCCAAACTTCCATAATAATACGGCCTATATGATGTGTTACATCATGCAGGCCATCAATGAAAACAGCGAACAGCTCAATGTATTCCGTCTGGGTCTTACTTACGAACTTCTGAGTGTCACTCGTGCGTTGGCCATGAACCAGGAGAAAGACTGTATTCCGGTCGCACTGCCGATACCAGGCGTGCCTGACAATGATATACTAAATGAGTCCGATGAGCCAATCGCCTATTTGCCGGTCGATCGCCTGGAGTCCATTCTACACCATATGATGCCTCAGGCCTGGCTGACAGTCGCCAAGGTTTCCCAGAGCGAGACAACTAATCTTAAATTCCTTCCGGCTTCACCGAATGACACGTCTGGAATTTCTCATGATTAA
Protein Sequence: MSSPDDAFDGANSPRLKKQLRETSSLSISSDDSVPGNNDGSNHSADVGKSKSEGNELKTNTINTQNSVENESDMSQHAEQEQFNSEQSGSRKAKRRKAKRAKQRRDSKEVALMGWSGPFPNLSPTHSLESSSDVDQQQLPTDLKAICATGLSIFPREDKEQRPPLSSSSSSDSTSFSPVSQLKTPATTTTTCFTLTTNSTTSSPKSTQTTNNNVNNNDTNSASMSIATSCPRSEPSSEPESESEPQADVAKQTVKHLNERPSSAAAGIETVANLDAVEDSNASFGSLKSRSSRKRGTSNRSSADGQQNESKRTKPTEQDNNGCSLRTRSKSLHDPNPDVPPRTPRARSICPATMLSQNEPAEQTPPSNETKTPARRRSVATFKLHPTDEFYRLPFKYGWKRELVLRSSASLSRQRGDVIFISPGGKKLRSREDIVPLLNGELTIDHFCFQRQMQQVGEEFETVRQAQPAPLRRKSLAVAKQQQQLANVNNQQLPPVPAPVSGKRVPKPKVPKGASPPPEGWTSTMAVKGNARVLAASNGNTSGGPGSGAGNSARKRSSNQAKQPAKPAPDPTVQANIQPQSGKGKTMICVYCLKLINEKQQAYPVGTASVNSYICMQCVKPSSKANLQQAAKGLPAEQGPTNGTKKQDSIDENLCTDTKASASVDADKNMNADVDANGNGNGGLLEIGGEIELPGALPPDQLLSDEVPASRAGNKITPKPLEVVVINGRKALAIAGEPPCPRLQVLPREPDLEIYEKYFLKRNCTAKEKRQNFVECISAGNLSCQVMSAVMKTLDLHDRVRMSNVCKTWSMIARDRSVWRTLKLRDTLITNWLFLLRDMVRYRTRELDMMGVKMTNPKMRLEGDLRVLKALRVLRTDACEAEFIQSVIKCIPRLLELRTTCTSRALSLASMKKMLELRVLRIRMIEPKAGIFSLQPLQNLEQLRELSLRGINNMAQLELLQLQGLKLLETLVLGSCRGMKAATFGQQVLPRLKRLRHLRLENHHSNRSFNINEIMEGISAGGSVKRVELINVNVDAELSRQLAACKSVQELLLMPNFHNNTAYMMCYIMQAINENSEQLNVFRLGLTYELLSVTRALAMNQEKDCIPVALPIPGVPDNDILNESDEPIAYLPVDRLESILHHMMPQAWLTVAKVSQSETTNLKFLPASPNDTSGISHD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00550889;
90% Identity: iTF_00530946;
80% Identity: -