Dkik000278.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila kikkawai
Gene Symbol
Foxk1
Assembly
GCA_018152535.1
Location
NW:3842867-3849399[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3e-40 2.5e-37 126.5 0.1 1 84 434 517 434 521 0.96
2 2 5.3 4.5e+03 -2.5 0.5 17 46 600 629 595 633 0.80

Sequence Information

Coding Sequence
ATGGCCGCCACTACAACATCAACAACCACAACACTAGCAACAACCAccggcaacagcagcaccaacaacaacagcagcatcaacagtgccagcagcagcagcaacaacaataataataatattgtaacGGTACATACCGTTCTGAACACTCCCACCAGCATTGCAGCCGCTGCCACAGCCGGCGTCGCTGCCTCCGCCGCAGCCGACGCAGCCACCGTTGCCATTGCCAAGGACATGTTGCAGCTGCATCatggtgcagcagcagcagccgccgcggCGCtgaacaataataacaacaatagcagcagcagcgccgagctgatcaacaacaacaactcagCAAACCACCCACCTGccaacaccaccacccccTCCGCCTCAGCCACCGCCAGCGCCTCAGCAACACCTCCGCCGTATGGAGAGCTACGGTTCAACCAGGAGGTGTTGCCCATCACGGACGCGGTGACAGTGATCGGACGCAACTCCTCCACATCGCTGGTCCACTTCAACGTGGCCGAGAATAATCTGGTGTCGCGCAAGCACTTCCAGGTCCTCTTCGATGTGGAGCTGCGCGCCTTCTTTGTCCAGTGCCTCAGCAAGAACGGTATATTCGTGGACGACTTCCTGCAGCGCCGTAATGTTGATCCATTGCGTTTGCCGCAACGCTGCTATTTTCGTTTTCCCAGCACGGAGATTCGGATTGAGTTTGAGAGTTATATGCCCGCCCCTCCATCGGATGCTGCCGGTACTCATTCGCCATCCTTGGTCGTAAGCAACGTTGGTGGCGTAGGTGCCGGTGGCGCTCATGTCATCATAACCCCGCCGCCAAGGGACgatttgcagcagcagcagcagatacaCCAACACCATCaccagcaactgcagcagcagcagcaccaccaccaccagtcAGCGCAGCACctgccgctgcagcagcagacgGCGCACCATCCACTTCCGCATACACCACACCACCCGCTCCACCACACAGCtctgcaacaacagcagcagcaacgcgCCGGTAACATCGTTGTGGGGCCCCCTGCGGGGGCAGCTGGCCACCTGATAGGCGCCGGTGATGGACCCGGTATCTACTCACCGCTCAAGATATCGATACCCAAGAAGGAGCAAAAGAGCCCCTACCTGTCACCAACTGGTACAATTAGCGCTGCCAACAGTTGTCCGGCTAGTCCACGTCAGGGTTTCATTCAAAATCAGCCCAGCAATTACAACAATTACAGTAACAACAACACgCAGGATCTGTTCCAGACCCCCTCCACAGCCAGTTACAATCACAACGAGAAGCCTCCGTATAGCTACGCCCAGCTGATCGTTCAGGCAATATCGGCTGCTCCAGACAAGCAGCTGACGCTCTCGGGCATTTATTCGTTTATTGTCAAGCACTATCCGTACTACCGCAAGGAGACCAACAAGGGCTGGCAGAATTCCATACGTCATAATCTCAGTTTGAATAGGTATTTCATCAAAGTAGCACGCTCCCAGGACGAGCCGGGCAAGGGTTCCTTCTGGCGAATCGATCCGGACAGCGGCGCAAAGCTAATCGATCATAGCTACAAGAAGCGTCGCCAACGGAGTAGCCAGGGCTTCCGTCCGCCTTACGGAATGCCCCGGTCGGCGCCGGTCTCGCCCAGTCACATGGATAATTCTCGGGAGAGCTCACCGTTGCAAGATATTGTGCTGCAATCCGCTCCTGGCTCGCCGGGAATGTCGCTGGAACAGCGCGCAGCAGATCCTGAAATCTACAACTCTCAAAATGcacaccagcaacaacaacaacaacaacagcagcagcagcagacgctGTCAAACAATTCCAATCAGTACAGCAGCGGCAGCCCGTACTATGTAACCAATCAAAACTCTGGCGTTGAGGGCAGCAACGCGAGCAGCGGAGGCGGCGGGGTGGGTGCTTTGATTGCGCTAAAGCGTAACCATGTGATGGCCGGCGGGGCAGCATCGCAGCATTCGTTgcaccagcagcaggcgcaggtggcgcaacagcaacagcagcagcagcattcagAGATTATCTACGAGGAGTTGCCGACCGACTACAGTGGCCATATCGAGGCCAGCGAGGAGGAGTGCGTcaccactgccactgccaccgaAGCCACCGTGGCCAAGCGACCCAAGTACGTGTCCGAGGTGCTCTGA
Protein Sequence
MAATTTSTTTTLATTTGNSSTNNNSSINSASSSSNNNNNNIVTVHTVLNTPTSIAAAATAGVAASAAADAATVAIAKDMLQLHHGAAAAAAAALNNNNNNSSSSAELINNNNSANHPPANTTTPSASATASASATPPPYGELRFNQEVLPITDAVTVIGRNSSTSLVHFNVAENNLVSRKHFQVLFDVELRAFFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYFRFPSTEIRIEFESYMPAPPSDAAGTHSPSLVVSNVGGVGAGGAHVIITPPPRDDLQQQQQIHQHHHQQLQQQQHHHHQSAQHLPLQQQTAHHPLPHTPHHPLHHTALQQQQQQRAGNIVVGPPAGAAGHLIGAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPSNYNNYSNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIYNSQNAHQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQNSGVEGSNASSGGGGVGALIALKRNHVMAGGAASQHSLHQQQAQVAQQQQQQQHSEIIYEELPTDYSGHIEASEEECVTTATATEATVAKRPKYVSEVL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00479981;
90% Identity
iTF_00489184;
80% Identity
-