Dboc014374.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila bocki
Gene Symbol
Foxk1
Assembly
GCA_008042715.1
Location
VNJY01007824.1:109261-113074[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.5e-40 2.4e-37 126.8 0.1 1 84 353 436 353 440 0.96
2 2 4.6 4.4e+03 -2.3 0.5 17 46 519 548 514 552 0.80

Sequence Information

Coding Sequence
ATGCCAACTTCTCTGCTCCGCTCCATTCCACACTGCCCGGGAAAGCGAAAGAGAGCAGAGCGCAAGCGTGTTGCCGCTCTCCGTCCTGGTCCgccgtCAAACCACCCACCTGccaacaccaccacccccTCCGCCTCAGCCACCGCCAGCGCCTCAGCAACACCTCCGCCGTATGGAGAGCTACGGTTCAACCAGGAGGTGTTGCCCATCACGGACGCGGTGACAGTGATCGGACGCAACTCCTCCACATCGCTGGTCCACTTTAATGTGGCCGAGAATAATCTGGTGTCGCGCAAGCACTTCCAGGTCCTCTTCGATGTGGAGCTGCGCGCCTTCTTTGTCCAGTGCCTCAGCAAGAATGGTATATTCGTGGACGACTTCCTGCAGCGCCGTAATGTTGATCCATTGCGTTTGCCGCAACGCTGCTACTTTCGTTTTCCCAGCACGGAGATTCGGATTGAGTTTGAGAGTTATATGCCCGCCCCTCCATCGGATGCTGCCGGTGCTCATTCGCCATCCTTGGTCGTGAGCAACGTAGGTGGCGTAGGTGCCGGTGGCGCTCATGTCATCATAACCCCGCCGCCAAGGGACgatttgcagcagcagcagcagatacaccaacaccatcaccagcaactgcagcagcagcagcaccaccaccaccagtcAGCGCAGCAcctgccgctgcagcagcagacggCGCACCATCCACTTCCGCATACACCACACCACCCGCTCCACCACACAGctctgcaacagcagcagcagcaacgcgcCGGTAACATCGTTGTGGGGCCCCCTGCGGGGGCAACTGGCCACCTGATAGCCGCCGGAGATGGACCCGGTATCTACTCACCGCTCAAGATATCGATACCCAAGAAGGAGCAAAAGAGCCCCTACCTGTCACCAACTGGTACAATTAGCGCTGCCAACAGTTGTCCGGCTAGTCCACGTCAGGGTTTCATTCAAAATCAGCCCAGCAATTACAACAATTacagtaacaacaacacgCAGGATCTGTTCCAGACCCCCTCCACAGCCAGTTACAATCACAACGAGAAGCCTCCGTATAGCTACGCCCAGCTAATCGTTCAGGCAATATCGGCCGCTCCAGACAAGCAGCTGACGCTCTCGGGCATTTATTCGTTTATTGTCAAGCACTATCCGTACTACCGCAAGGAGACCAACAAGGGCTGGCAGAATTCCATACGTCATAATCTCAGTTTGAATAGGTATTTCATCAAAGTAGCACGCTCCCAGGACGAGCCGGGCAAGGGTTCCTTCTGGCGAATCGATCCGGACAGCGGTGCCAAGCTAATCGATCATAGCTACAAGAAGCGCCGCCAACGGAGTAGCCAGGGCTTCCGTCCGCCTTACGGAATGCCCCGTTCGGCGCCGGTCTCGCCCAGTCACATGGATAATTCTCGCGAGAGCTCACCGTTGCAAGATATTGTGCTGCAATCCGCTCCTGGCTCGCCGGGAATGTCGCTGGAACAGCGCGCAGCAGATCCTGAAATCTACAACTCTCAAAATgcacaccagcaacaacaacaacaacagcagcagcagcagcagacgctgTCAAACAATTCCAATCAGTACAGcagcggcagcccGTACTATGTAACCAATCAAAACTCTGGCGTTGAGGGCAGCAACGCGAGCAGCGGAGGCGGCGGGGTGGGTGCTTTGATTGCGCTAAAGCGTAACCATGTGATGGCCGGCGGGGCAGCATCGCAGCATTCGttgcaccagcagcaggcgcagcagcaggtggcgcaacagcaacaacagcagcagcagcagcattcagAGATTATCTACGAGGAGTTGCCGACCGACTACAGTGGCCATATCGAGGCCAGCGAGGAGGAGTGCGTtaccactgccactgccaccgaaGCCACCGTGGCCAAGCGACCCAAGTACGTGTCCGAGGTGCTCTGA
Protein Sequence
MPTSLLRSIPHCPGKRKRAERKRVAALRPGPPSNHPPANTTTPSASATASASATPPPYGELRFNQEVLPITDAVTVIGRNSSTSLVHFNVAENNLVSRKHFQVLFDVELRAFFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYFRFPSTEIRIEFESYMPAPPSDAAGAHSPSLVVSNVGGVGAGGAHVIITPPPRDDLQQQQQIHQHHHQQLQQQQHHHHQSAQHLPLQQQTAHHPLPHTPHHPLHHTALQQQQQQRAGNIVVGPPAGATGHLIAAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPSNYNNYSNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIYNSQNAHQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQNSGVEGSNASSGGGGVGALIALKRNHVMAGGAASQHSLHQQQAQQQVAQQQQQQQQQHSEIIYEELPTDYSGHIEASEEECVTTATATEATVAKRPKYVSEVL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00479981;
90% Identity
iTF_00527114; iTF_00532916; iTF_00571713; iTF_00477826; iTF_00612621; iTF_00594352; iTF_00561553; iTF_00491319; iTF_00593657; iTF_00525698; iTF_00569505; iTF_00617442; iTF_00479981; iTF_00482791;
80% Identity
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