Dkam011597.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila kambysellisi
Gene Symbol
thap1-a
Assembly
GCA_035042185.1
Location
JAWNLS010000945.1:402274-404709[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.041 2.9 8.6 1.3 1 23 390 413 390 413 0.91
2 7 0.62 44 4.9 2.3 2 23 574 597 573 597 0.90
3 7 0.039 2.7 8.7 0.5 2 21 609 628 608 629 0.95
4 7 1.1 74 4.2 3.0 1 20 644 664 644 666 0.93
5 7 6.4e-05 0.0045 17.4 1.5 1 23 695 717 695 717 0.97
6 7 9.8e-06 0.00069 20.0 1.0 1 23 723 746 723 746 0.96
7 7 2.8 2e+02 2.8 0.0 1 14 752 765 752 769 0.80

Sequence Information

Coding Sequence
ATGCCCGCCCACTGTGCGGTTGTCAATTGCAGtgacaaatatgtacattcCGGCAGCATATCCTTTCACAGATTTCCATTTAAACGTAAGGATTTGCTGCAGAAATGGAAGGACTTCACACAACGCAGCGGCCAATGGATGCCCTCGAAATGGAGTGCGGTGTGCAGTCGCCATTTCAGCGACTCTGACttcaattgcagcaacaatcgCAAAACGTTGAAAAAGAATGCGGTGCCCACCTTGCGACTGCTGAATGCCGAATCACTGcaagtggagcagcagcaacagcagcagccggcgccaacagcagcgactGAAACACCAACGACCAACTGCAGCAAGAGCACGTGTCGTTTCTGTGGCAACACGGCGCCAAATTGTGTGTCTTTTGACAAGAGTTTCGAGCTCTTTGGCATGATCCAGAAATGTTTTCCCACACTGCAAATCCTACAGGATGATACACTGCCGCTGCCAAAGGACATTTGTGGCGATTGTTGTCGGCAGTTGCAGCGTTTCTCGCAGTTCTGTGATGTGGTTATGTTGGCACAAAGTGAACTCCAGCGCAAATATCGTCGCCAGCTAAAGATCAAACAGGAGCCGGTGGTGCGTGTGAAGCAGGAGGCATGTGAGAGTCTCGATAATCTCTTTCCCGACGAACTGGACATTGGCCTGGACGAGGCGTGCTGCGATCATGAGCCGGAGCCACACGATGAGACTGAACAGAAGTTTCAATTCTGTGATTTCAATCCGCAGGACATCATCAACAATTGTGATATTATGGAGATTATCAATCTGGATGATCCATTTATCAATATAACCGATGATGCAGATGTGCCGCAGCCCGTAACCGTTTTGCCCACTGCGCAGGAGTTGCTGCAATCGGAGTTGCTCACCGAGGAGCACAACTACGCCAAGGAGGATTGGCAGCTGTTGCCTTTGCAGCAATATAAAACGGAGAAAGTGGAGGGCATTGACTTGAATGAAGCAGttgctcctcctccagctgcagctccaaGTGAGACCCGTAGCTGCAAGCCAATTGTGACTAATGTCAGCCAGATACCCAATCCGATGATCTGTGAACTGTTGCCACCGCCAGCGGCGAGCAGCAAGCCCAACATTGTCGTCCTCAATGATAGCGTGGTGCAATCCTCGGCATTTCGTCTTCACGATTGCAGCCTGTGTAGCAATAAATTCTTTACGGCGGAGAGTCTGCAGCAGCACTATGCACAGGCACATGGCACACCCACAGAGACACCGCCTGCTCCACTTCCTCATTCagcgcctgttgctgctgctcctccagcacctgcttctgctcctcctCTGCCTGCTCCAActtctgctcctcctcctcccgcTCCCATGGTTAGCGTTCCTCCTCTAAACATCAGTCTCCTCAACGCTGGCAGTTCCCTCAAGCTGGAGGCTAACAGCTCCGTGTCGctaccagctgctgctgtggacTACTGGCAAGCGGATTGGTGGCCTGCTGACCAGTTGCCGGCCAAGACAAAGATCGACATACTGGACATTCTGCATTGCAACGATCTGATTCCCATGCCACCAGCAGTAAGTCATCAGCAGTCAGTCGATGTGCAGCCGTTGGCCTATGCGAAGTTGGCGGTACGTTTCCGCCGGCTACAGCACAAGTGCCGCCAgctgcggcaacagcaacatcaacagcagcgtcATCCACGTCCACTGCATCCTCGCCTGCATTGCGGACGCTGCAAACGTGGCTTTGGAAGCGTGCAACTGTTGCTACAACATCGTCGCAGGAGGCGACATTTTGTGGTGCCACCGCAACGCACATTTGCCGTCCGTTGCTTTGGCTGCCTGCGACTGTTTCGAACACGGCTTGGGCTGCGTCAGCACATGCGCTACATCTGCCAATCGCTACCGCTGCGCAATGCTCGGCTGCAAAGCTACAAGTGTCGGCACTGCCAGAGCATCAGTTTCACCCACTGGCGCGTCTATCGGCGGCACGAACTTAAGTGCAAGCAGCGGCaggcgaacagcagcagcagaaatcgCCGTTCTGGCAAGCGGCGACGATCGCATGCGGCTCAAAGGACCCACCACAGTTGCGGCATTTGCCAGAAGATATTTAGTTCGTTGACGGGTTTGAAGCAGCATCGGATTACGCACAGCTCGGAGCGACGCTACAAATGCACCATCTGTGAGCGTGTGTTCAAGCGTCGCAATGGTCTATCCCAGCACGTCCGGGGCTATCATCTGCAGTTCAAGCCGCACGAGTGTCCTGTGTGCCAGCATCGATATGCACTCAAGGGCGACATGCTGCGCTGCCGGCACTCGCAGCGAAGGGGCGCCATTGCCAGCGAAACTGAGCAGGCAAAGATTGCTCAGCATTAG
Protein Sequence
MPAHCAVVNCSDKYVHSGSISFHRFPFKRKDLLQKWKDFTQRSGQWMPSKWSAVCSRHFSDSDFNCSNNRKTLKKNAVPTLRLLNAESLQVEQQQQQQPAPTAATETPTTNCSKSTCRFCGNTAPNCVSFDKSFELFGMIQKCFPTLQILQDDTLPLPKDICGDCCRQLQRFSQFCDVVMLAQSELQRKYRRQLKIKQEPVVRVKQEACESLDNLFPDELDIGLDEACCDHEPEPHDETEQKFQFCDFNPQDIINNCDIMEIINLDDPFINITDDADVPQPVTVLPTAQELLQSELLTEEHNYAKEDWQLLPLQQYKTEKVEGIDLNEAVAPPPAAAPSETRSCKPIVTNVSQIPNPMICELLPPPAASSKPNIVVLNDSVVQSSAFRLHDCSLCSNKFFTAESLQQHYAQAHGTPTETPPAPLPHSAPVAAAPPAPASAPPLPAPTSAPPPPAPMVSVPPLNISLLNAGSSLKLEANSSVSLPAAAVDYWQADWWPADQLPAKTKIDILDILHCNDLIPMPPAVSHQQSVDVQPLAYAKLAVRFRRLQHKCRQLRQQQHQQQRHPRPLHPRLHCGRCKRGFGSVQLLLQHRRRRRHFVVPPQRTFAVRCFGCLRLFRTRLGLRQHMRYICQSLPLRNARLQSYKCRHCQSISFTHWRVYRRHELKCKQRQANSSSRNRRSGKRRRSHAAQRTHHSCGICQKIFSSLTGLKQHRITHSSERRYKCTICERVFKRRNGLSQHVRGYHLQFKPHECPVCQHRYALKGDMLRCRHSQRRGAIASETEQAKIAQH