Basic Information

Insect: Drosophila atroscutellata
Gene Symbol: Thap1
Assembly: GCA_035041605.1
Location: JAWNLA010000092.1:13752128-13754589[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.072 4.6 7.8 1.4 1 23 392 415 392 415 0.89

2 7 0.3 19 5.9 1.8 2 23 585 608 584 608 0.90

3 7 0.039 2.5 8.7 0.5 2 21 620 639 619 640 0.95

4 7 1.1 69 4.1 3.0 1 20 655 675 655 677 0.93

5 7 0.00029 0.019 15.3 1.5 1 23 706 728 706 728 0.97

6 7 3.5e-06 0.00022 21.4 0.9 1 23 734 757 734 757 0.97

7 7 2.9 1.8e+02 2.8 0.0 1 14 763 776 763 780 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.072	4.6	7.8	1.4	1	23	392	415	392	415	0.89
2	7	0.3	19	5.9	1.8	2	23	585	608	584	608	0.90
3	7	0.039	2.5	8.7	0.5	2	21	620	639	619	640	0.95
4	7	1.1	69	4.1	3.0	1	20	655	675	655	677	0.93
5	7	0.00029	0.019	15.3	1.5	1	23	706	728	706	728	0.97
6	7	3.5e-06	0.00022	21.4	0.9	1	23	734	757	734	757	0.97
7	7	2.9	1.8e+02	2.8	0.0	1	14	763	776	763	780	0.80

Sequence Information

Coding Sequence: atgccCGCACACTGCGCGGTGGTCAATTGCAGcgataaatatgtacattccGGCAGCATATCCTTTCACAGATTTCCATTTAAACGCAAGGATTTGCTGCAGAAATGGAAGGACTTCACGCAGCGCAGTGGCCAATGGATGCCCTCGAAGTGGAGTGCGGTGTGCAGTCGCCATTTCAGTGACTCCGActtcaattgcagcaacaatcgcAAAACGTTGAAAAAAAATGCGGTGCCCacgttgcaactgctgcctgAAGATGCCGAATCCCTGCAagtggtgcagcagcaacagcagcagccgacgcCAACAGTAGCGACTGAAGCTCCAAcgagcaactgctgcaagaGCACATGTCGCTTCTGTGGCAACACGGCGCCAAATTGTGTGTCATTCGACAAGAGTTTCGAGCTCTTTGGCATGATCCAGAAATGTTTTCCCACCCTACAAATCCTGCAGGATGATACACTGCCGCTGCCGAAGGACATTTGTGGCGATTGCTGCCGGCAGCTGCAGCGTTTTTCGCAATTCTGCGATGTGGTGATGCTGGCGCAAAGTGAACTCCAGCGCAAATATCGGCGCCAGCTGAAGATCAAACAGGAGCCAGTGGTGCGTGTGAAGCAGGAGGCATGCGAGAGTCTCGACAATCTCTTTCCCGACGAGTTGGACATGGGCCTGGACGAGGCATGCTGCGATCATGAGCCGGAGCCACACGATGAGACCGAACAGAAGTTTCAATTCTGTGATTTCAATCCGCAGGACATCATCAACAACTGCGATATTATGGAGATTATCAATCTGGATGatccatttataaatataaccgATGATGCAGATGTGCCTCAACCCGTGTCCGTGTTGCCCACAGCGCAGGAGTTGCTGCAAACGGAGTTGCTCACCGAAGAGCACAACTATGCCAAGGAGGATTGGCAGCTGCCGCCGTTGCAGCAATATAAAACGGAGAAAGTGGAAAGCTTTGAATTGAATGACGCAGTTGttcctcctccagctgcagctccaaGTGAGACGCGCAGCTGTAAACCAATTGTGACCAATGTCAGCCAGATACCCAATCCGATGATCTGTGAACTGTTACCACCGCCAGCGCCGAGCAGCAAGCCCAACATTGTCGTCCTCAACGACAGTGTGGTGCAATCCTCGGCATTTCGTCTCCACGATTGCAGCCTGTGCAGCAATAAATTCTTTACCGCGGAAAGTCTGCAGCAGCACTATGTACAAGCACATGGCACGCCCACAGGGACGACGCCTACTCCACCTCCTCCTGCCGCACCTGTTGCtgatcctcctcctcctccagcacctgcttctgctcctcctgctgctgttcctcctGTGCCCGCTCCAACCCCTTCTCCTGCCGCTCCCATGGTTAGCGTTCCTCCTCTAAACATCAGTCTCTCCAGCGCTGGCAGCTCCCTGAAGCTTGAGGCCAGCAGCTCCTTATCGCTACCACCTGCAGCTGTGGACTACTGGCAAGCGGATTGGTGGCCCGCTGCCCAGCTGCCGGCCAAGACAAAGATCGATATACTGGACATGCAGCGTAGTTTTCTGCATTGCAACGATCTGATTGCCATGCCACCAGCAGTGAGTCATCAGCAGTCAGTCGATGTGCAGCCGCTGGCCTATGCCAAGTTGGCGGCTCGTTACCGCCGGTTGCAGCACAAGTGCCGCCAgctgcggcaacaacagcatcaaaagcAATGTCATCCACCTCCACTGCATCCTCGACTGCATTGCGGACTCTGCAAGCGTGGCTTTGGCAGcgtgcaactgttgctgcaacatcgTCGTAGGAGGCGGCATTTTGTGGTGCCACCGCAACGCACATTTGCCGTGCGTTGCTTTGGCTGCCTGCGACTGTTTCGCACACGGCTCGGACTGCGTCAGCATATGCGTTACATCTGCCAATCGCTGCCGTTGCGCAATGCTCGGATGCAGAGCTACAAGTGCCGGCACTGCCAGAGCATCAGTTTCACCCACTGGCGCGTCTATCGGCGGCACGAACTCAAGTGCAAGCAGCGGCaggcgaacagcagcagcagaagtcgCCGGTCCAGCAAACGTCGCCGATCGCATGCGGCTCAAAGGACCCACCACAGTTGCAGCATTTGCCAGAAGATATTTGGTTCGTTGACTGGTTTGAAGCAGCATCGGATTACGCACAGCTCGGAACGACGCTACAAGTGCAGCATATGTGAGCGGGTGTTCAAGCGACGCAATGGTCTATCCCAGCACATCAGGGGCTATCATCTGCAGTTCAAGCCGCACGAGTGTCCTGTGTGCCAGCATCGATATGCCCTCAAGGGCGACATGCTGCGCTGCCGTCACTCGCAGCGACGGGGCGCCATTACCAGCGAATCTGAGCAGCCGAAAAGTGCTCAGCATTAG
Protein Sequence: MPAHCAVVNCSDKYVHSGSISFHRFPFKRKDLLQKWKDFTQRSGQWMPSKWSAVCSRHFSDSDFNCSNNRKTLKKNAVPTLQLLPEDAESLQVVQQQQQQPTPTVATEAPTSNCCKSTCRFCGNTAPNCVSFDKSFELFGMIQKCFPTLQILQDDTLPLPKDICGDCCRQLQRFSQFCDVVMLAQSELQRKYRRQLKIKQEPVVRVKQEACESLDNLFPDELDMGLDEACCDHEPEPHDETEQKFQFCDFNPQDIINNCDIMEIINLDDPFINITDDADVPQPVSVLPTAQELLQTELLTEEHNYAKEDWQLPPLQQYKTEKVESFELNDAVVPPPAAAPSETRSCKPIVTNVSQIPNPMICELLPPPAPSSKPNIVVLNDSVVQSSAFRLHDCSLCSNKFFTAESLQQHYVQAHGTPTGTTPTPPPPAAPVADPPPPPAPASAPPAAVPPVPAPTPSPAAPMVSVPPLNISLSSAGSSLKLEASSSLSLPPAAVDYWQADWWPAAQLPAKTKIDILDMQRSFLHCNDLIAMPPAVSHQQSVDVQPLAYAKLAARYRRLQHKCRQLRQQQHQKQCHPPPLHPRLHCGLCKRGFGSVQLLLQHRRRRRHFVVPPQRTFAVRCFGCLRLFRTRLGLRQHMRYICQSLPLRNARMQSYKCRHCQSISFTHWRVYRRHELKCKQRQANSSSRSRRSSKRRRSHAAQRTHHSCSICQKIFGSLTGLKQHRITHSSERRYKCSICERVFKRRNGLSQHIRGYHLQFKPHECPVCQHRYALKGDMLRCRHSQRRGAITSESEQPKSAQH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00500666;
90% Identity: iTF_00525522;
80% Identity: -