Dhet003096.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila heteroneura
Gene Symbol
Mtf1
Assembly
GCA_035042245.1
Location
JAWNLO010000267.1:451724-460467[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.00013 0.0085 16.4 1.9 1 23 336 360 336 360 0.99
2 6 0.00027 0.017 15.4 0.4 1 23 366 390 366 390 0.98
3 6 6.9e-05 0.0044 17.3 0.9 1 23 396 420 396 420 0.98
4 6 1.6e-07 1e-05 25.6 5.1 1 23 425 447 425 447 0.98
5 6 1.2e-06 7.7e-05 22.8 3.2 1 23 453 477 453 477 0.99
6 6 0.00015 0.0093 16.3 3.7 1 23 483 507 483 507 0.95

Sequence Information

Coding Sequence
ATGGATGCAAGCAAcgatcatcagcaacaacaacaacaacagcagcagcaacaacaacaacaatactatGAGCACAGTTGGAAGTCAGCCAATCATGGAAATTCCTTATCAGACAGCAGGGATTATGATACAAACTCAACGCGCACATCGCTGACTGGTTCGCCGCCGATAACATCATCAACTGGACTGGACTTTAATGGATTTGAGGACAAAGCGCTGCTGGCATCGCTGCTTGCGCCCAAATTAGATGatgccggcagcagcagtagcagcaacagcatttacACAACTGGGGAGCAACAGGTGCTGCAACCATTAggcttaacaacaacaaccacaacagcgacggcgacagcaacaacaacagcgacataCACTTTATATGGCCCGGCGGAATTGCAGGCACAGACAGTTATAGCTGACGAGGACGATGACGCTGACGATGACTTAGTTGAGGACGAATTGGTCACACTGACAAGTGCACCCCTGTTGCTaaccagcaccaacaacaacaaccacaatagcaacaacaacaatagcacatcatccacacacacattatccACACCAATTTCACCATATCATCAAACACAATCCACACCGAAACCTGTAATAGCAACATTGGGCACATATAATCTGGATGATATTTGCTTTACGTTGGAATATCAGTTTCTAAATCAAAAGCTCGTCCAGGTGCAGCCACCCACAGTGGTGTCCTTCAGCATGTTATCGccagaagaagatgaagaacaacaacccacaaaaacaacagcagctagcagcgacaacaacaacaacaactcaagtTCTTCTCCTcctactacaacaacaacaacaactgcatatTTCACTCTTGGGACGAGCTATATCAAAGAGCAAACAGAGCCCGATGAGGACAATGAGCTGGCTCACTGCATCCATCCGGGCGCCCTGCACAAGGACACCGACGAGGATCAGCTGTTGATGGCGATGGCCTACGAGAGCTCCGATGAAGCTCTCAGCCGTTATAAATGCAACTATGAAAACTGTTATCGCAGCTACAGCACAATTGGAAATCTGCGTACACATTTAAAGACACACACAGgaGATTACAGCTTCAAGTGTACGGAGGAGGGCTGTAACAAGGCATTCCTCACATCATACAGCTTGAAAATCCATGTACGCGTCCACACCAAAATCAAACCCTACGAATGCGAAGTCAGCGGCTGTGATAAGGCCTTCAACACGCGATACAGATTGCACGCCCATCTGCGACTGCACAATGGCGAGACATTCAATTGTGAAATGTGCCAAAAGTGTTTCACAACCCTCAGCGATCTGAAGAAACATATGCGCACCCACACCCAGGAGCGACCCTACAAGTGTCCCGAGGATGATTGCGGCAAAGCATTCACCGCATCGCATCATTTGAAAACGCATCGGCGCACGCATACCGGCGAGAAGCCGTATCCCTGTCAGGAGGATAGCTGCCAGAAGTCATTCAGCACATCGCACAGCTTGAAATCGCACAAGAAGACGCATCAGCGCCAGCTGCTCAGCAAGgggagcaacaaaaagaaatcgaAGCGTGCTCAGAAACTGttgcagcaggaacagcaccAGGAGCAAGAGCaactggagcaggagcaactgGAACAGGAGCTGTTGGTGCTGCAAAAGACAGACGACATGGTGCTCTTCAATCCGGGCAGTCAGAGCTCGGAGACAACGAGCAACGATAGCGGCGTTGTAATCCAGCAGTTGGCCAATGTCTGCTTGCTGCCAGAGACATCGCAAGCGTATCCTTTGTCCTATGCGGCCGAGGAGGAGATACCCAGTCCATGGATCGATGCCGGTGTGCTCGTTTCCAAGCCCATTATGCCGATGGCACCGTTGACCGATGCCTGCGTTGCACTCGCCACAGAAATGCCCAGTTTTGTAGATTTGACACACACATTTGGCAGTGCTGCTATCAGTGGTGGCACCATGGAGGAGCCAACACCACTCGATGTCGAAATGTTGAACAGCACAAATTCAAATCCAACAAATACAACTGGCAATCTGCCCACGCTGGAGCTAAATCCGCAGAACATTGAGGAGCTGCTGCGCGACGATAGTTTTGACAACGATGAGGATATGGAAACCGAATCCCTGCTCAACGACATCCTGATGACCATTGATAATAATAGTGCGCTGCTGCAGGCGACACTCCATCAGGCAGCCCAGGTACCCAGCGATGCATCGGGTCTGGTGGAGCTGGACATAAGGGACAATAAGCCGACACTTAAACAGATTACAGCAGATGCGGGCATCTGCAATTGCACTAATTGCAAGTGTGATCAGACCAAGAGCTGTCATGGCGGTGACTGTGCTGCAACCAACAAATCAACCACCACCAGTCACaaacccacaacaacaacaacaatacaaacgGCGAACAGCAGCTCGAAACGCATCTGTGGCAGCGTTGCCAGCAAAAAAGTGAGTAGACGCGATGCGGAAATAAATCAGAACATCGAGGATGTTGCTTTACTGCTCCAGAATTTGGCTTCCATGAGTGGCGGaagcagcagcgctgctggcggtggtggtggttgctgtggtggtggtggtgctgctgctgctcctcctcctcctccagttgcagcagctccagcCTCGGCTTGTGCTTGCTCCACAACTGTGTCCAAGCCGGCGCCAACTGGAGGCTGTTGTGCTCCACCAGCACCTTCGCCGCCcgtcagctgcagctgctgctcctccaacTCTGGAGGCTGCtgcacaccagcaacagcaccgctgccgccgccgcctcccgttgccagctccagctgctgctccttgaaAGCACCACCGCCTGTAATCCACAGCTCCACGACCGCTCTCAAGGGCAATGCGTGCACGTGCAAGAGTCCGGCGGAGGGCGTCGCCAATGGCTGTTGTGTTGTCATCTGCATGAAAACTTTGCAAGCCCTACGCAAAGTTCTGACACGCCGGAACCTCAACCTAATGCTTTGTCCGCAACAGAACTAA
Protein Sequence
MDASNDHQQQQQQQQQQQQQQYYEHSWKSANHGNSLSDSRDYDTNSTRTSLTGSPPITSSTGLDFNGFEDKALLASLLAPKLDDAGSSSSSNSIYTTGEQQVLQPLGLTTTTTTATATATTTATYTLYGPAELQAQTVIADEDDDADDDLVEDELVTLTSAPLLLTSTNNNNHNSNNNNSTSSTHTLSTPISPYHQTQSTPKPVIATLGTYNLDDICFTLEYQFLNQKLVQVQPPTVVSFSMLSPEEDEEQQPTKTTAASSDNNNNNSSSSPPTTTTTTTAYFTLGTSYIKEQTEPDEDNELAHCIHPGALHKDTDEDQLLMAMAYESSDEALSRYKCNYENCYRSYSTIGNLRTHLKTHTGDYSFKCTEEGCNKAFLTSYSLKIHVRVHTKIKPYECEVSGCDKAFNTRYRLHAHLRLHNGETFNCEMCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLLSKGSNKKKSKRAQKLLQQEQHQEQEQLEQEQLEQELLVLQKTDDMVLFNPGSQSSETTSNDSGVVIQQLANVCLLPETSQAYPLSYAAEEEIPSPWIDAGVLVSKPIMPMAPLTDACVALATEMPSFVDLTHTFGSAAISGGTMEEPTPLDVEMLNSTNSNPTNTTGNLPTLELNPQNIEELLRDDSFDNDEDMETESLLNDILMTIDNNSALLQATLHQAAQVPSDASGLVELDIRDNKPTLKQITADAGICNCTNCKCDQTKSCHGGDCAATNKSTTTSHKPTTTTTIQTANSSSKRICGSVASKKVSRRDAEINQNIEDVALLLQNLASMSGGSSSAAGGGGGCCGGGGAAAAPPPPPVAAAPASACACSTTVSKPAPTGGCCAPPAPSPPVSCSCCSSNSGGCCTPATAPLPPPPPVASSSCCSLKAPPPVIHSSTTALKGNACTCKSPAEGVANGCCVVICMKTLQALRKVLTRRNLNLMLCPQQN