Dhet005816.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila heteroneura
Gene Symbol
Rfx2
Assembly
GCA_035042245.1
Location
JAWNLO010000516.1:612393-619271[-]

Transcription Factor Domain

TF Family
RFX
Domain
RFX domain
PFAM
PF02257
TF Group
Basic Domians group
Description
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.3e-38 5.2e-34 116.6 0.1 3 78 350 425 348 426 0.97

Sequence Information

Coding Sequence
ATGCATTCGCGATTCGGCTTCGACTGCCAGACGCGTcaccaccaacaccatcaGCCACACCACctgcatcatcagcagcagcagcagcagccgcagccgcatcAACATCATCCTCAGCCACAGTCGAATATTACgtcaccgccgccgccgccgatCGCCGCCGCCTATACGAATCTCTTGGAGAAGTGTCGTTGCAAGCTGCATTCACAGCACCAacacccacatccacatcacCATCCGCACCACCctcaaaatcagcagcagcagcagcaacaacagcatccatCGCAGCTGTCACATCCACACCAGTTGCTGccacaccaacagcagcagttgccagtGGCGGCGACAGCAGCGCCACTAGCGCCGCTGCCAGCGgcccagttgcagttgcaactgcaccatcatcatcatcatcatcaccatcagaCGTTCGTGGCCACGGCCAGTGCCGtcaactacagcagcagctgtacaACAATTggcgccgctgccgccgcctccACAGGGACAGCATCGAGctcagcagcaaccacagcaatgtatcaccatcaccaccatCGACGTCACAACAATTTGTCCTATTGCGGTGTTTCGGGTCAGGAGCAAAACTATCAAGTGCAATATGTTGATTCGGAACTATATCACAGCAATTCGAGCCAGACGCAAATGACGTACCCATTCTGCCCGGTGGGCGATTATCAGGGCAATGGCCAGACGTATTACtcgacaacggcagcaactggcaactatGCAACAGCGGCGACAGGCAGCACAGCAAATGCCCATTCTACGACGCTGCCGTATCTGGTACCTGTGGACGAGAGTCTGCTATTGAATGGGTCCTCGCAGTCACACAGCCGTGACTCGCCGCACAGCCTGACGCATGAGGTTGCCTACATACAGGAGGCGCAGAGCACACCACAAACGCCCACCTCGACAACAACCACCAATTCGGCCAGCGGCGGCAGCATCGGAAACGGTGCCGATGGGGCGTCACCCGATAGTGACCAGAGCGCCATGGGAACCAGCAACAAGATTGCCTCGGCAACGATTAAGTGGCTGTCGCGCAACTACGAGACTGCCGACGGAGTTAGTCTGCCACGTTCAACGTTATATAACCACTACATGCAGCATTGCAACGAACAGAAGCTGGAGCCAGTGAATGCAGCCAGTTTCGGCAAGTTGATACGCTCTGTGTTCTCTGGTCTGCGCACACGTCGCTTGGGCACGCGCGGCAACTCCAAGTATCATTATTATGGCATTCGCATCAAGCCCGGCTCACTGCTAATTCATCAATCCATGGAGGACAAAGCCATGCAAGGCTATGGCACGCCAACGGGCAATGGCGCCATGGccaacgtcagcagcagcagcatcggcgCCACCCAACTGGGCAGCTCAAATGGCAGCAATGGCTTGTCATCGAATTCTGGCCAGCGCTCAGCTGGCGCCAAGAAGCACAACTTCAAGCCCGAAACCTACGAGGCTTGCATACAGTACATTGGCGACGGTGCTGGCGCCATGCCCGTCTTTCCGGCCATCGAACTGAGCCACAGTTTTCACAGTGAACTCACCCTGGACGATGTGGACACTTTTCGTGCACTTTACCGCGAACATTGCGAATCATTTTTGGATGCTGTGCTCAATCTGGAGTTTGGCACGGTTGAGTTTTTGCTGCGCGACTTTTGGCGCACCAcggacaacaacaatctgGACGAGTGCGAGGAGGAGAAGTACTTGAGCAAGACGAAACTGTATCTGTTGTGCCACTGCGCAGAAGTGCAAAAGTTTGTGCGCGAGGTGGACTATCAGTTCTATCAGAACACCGTGGACGTTATAATACCAGATGTGCTGCGCTCGATACCCAACGCACTGACTCAGGCCATACGCAACTTTGCCAAGAATCTGGAGCTGTGGCTGTGCGAGAGCATGCTGGGTGTGCCGGAGCAGCTGTCACAGATTAAGACTAGCGCCGTCTCGGCATTTTGCCAGACGCTGCGTCGCTACACATCCCTGAATCATCTGGCGCAGGCAGCACGAGCCGTGCTACAGAACGGTGCACAAATATCCCAAATGCTCAACGATCTAAATCGTGTGGACTTTCACAATGTGCAGgAGCAAGCCGCCTGGGTGAGCCAATGTGCACCGGATGTGGTGCAGCGTCTGGAGAACGATTTTAAGgctgcactgcagcagcaaagctcACTGGAGCAATGGGCCAGTTGGCTGCAGCTTGTGGTGGAGTCAGCAATGGAGGAGTATACGGGCAAACCGAGCTATGCGCGTGCCGCTCGTCAGTTTCTGTTGAAATGGAGCTTCTACAGCTCGATGATAATTCGAGACTTAACACTGCGTTCCGCATCGAGCTTTGGCAGCTTTCATCTGATCCGGCTGCTCTTCGATGAGTATATGTTCTATCTGGTGGAGCACAAGATAGCCGAGGCGCAGCAGAAGACGGCCATTGCGGTCATTTGCGAGCGCATGAAGAAGGAAATGGACTTTGAGTTCGAGTGCCAGTTCGCCTATATCACCAGCGATGGGGAGCAGCAAGCAACGGCCACCTCTGTCAGTGGCGGCGCCAATGGTGgcgttggtggtgctggtgccgtaggtgttgctggtgttgcagcGACTGCGGCAAGTGCCACCATTGCTGGCAACGAAGCCAAGCGTCTGAAGCAGGAATGA
Protein Sequence
MHSRFGFDCQTRHHQHHQPHHLHHQQQQQQPQPHQHHPQPQSNITSPPPPPIAAAYTNLLEKCRCKLHSQHQHPHPHHHPHHPQNQQQQQQQQHPSQLSHPHQLLPHQQQQLPVAATAAPLAPLPAAQLQLQLHHHHHHHHHQTFVATASAVNYSSSCTTIGAAAAASTGTASSSAATTAMYHHHHHRRHNNLSYCGVSGQEQNYQVQYVDSELYHSNSSQTQMTYPFCPVGDYQGNGQTYYSTTAATGNYATAATGSTANAHSTTLPYLVPVDESLLLNGSSQSHSRDSPHSLTHEVAYIQEAQSTPQTPTSTTTTNSASGGSIGNGADGASPDSDQSAMGTSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCNEQKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLIHQSMEDKAMQGYGTPTGNGAMANVSSSSIGATQLGSSNGSNGLSSNSGQRSAGAKKHNFKPETYEACIQYIGDGAGAMPVFPAIELSHSFHSELTLDDVDTFRALYREHCESFLDAVLNLEFGTVEFLLRDFWRTTDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLELWLCESMLGVPEQLSQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLNDLNRVDFHNVQEQAAWVSQCAPDVVQRLENDFKAALQQQSSLEQWASWLQLVVESAMEEYTGKPSYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQQKTAIAVICERMKKEMDFEFECQFAYITSDGEQQATATSVSGGANGGVGGAGAVGVAGVAATAASATIAGNEAKRLKQE