RFX
- Domain
- RFX domain
- Group
- Basic Domians group
- PFAM
- PF02257
- Desciption
- RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].
- Rederence
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- MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. Reith W, Herrero-Sanchez C, Kobr M, Silacci P, Berte C, Barras E, Fey S, Mach B. Genes Dev. 4, 1528-40, (1990).
- Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Gajiwala KS, Chen H, Cornille F, Roques BP, Reith W, Mach B, Burley SK. Nature 403, 916-21, (2000).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000053 | Abrostola tripartita | Atri018794.1 | Rfx2 |
| iTF_00000054 | Abrostola tripartita | Atri020329.1 | RFX7 |