Basic Information

Insect: Drosophila helvetica
Gene Symbol: VEZF1
Assembly: GCA_963969585.1
Location: OZ018403.1:9027623-9032269[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 25 0.0019 0.18 12.7 1.1 1 23 215 237 215 237 0.96

2 25 0.033 3.1 8.9 1.7 1 23 243 265 243 265 0.97

3 25 0.049 4.6 8.3 2.1 2 23 297 318 296 318 0.97

4 25 9e-05 0.0086 16.9 1.6 1 23 391 414 391 414 0.94

5 25 3.2 3.1e+02 2.6 1.3 2 22 422 442 421 442 0.95

6 25 0.54 52 5.0 1.5 1 23 451 473 451 473 0.97

7 25 0.23 22 6.2 0.2 3 23 485 505 483 505 0.96

8 25 0.0085 0.81 10.7 1.2 1 23 587 610 587 610 0.97

9 25 0.0039 0.37 11.8 0.2 2 22 620 640 617 640 0.90

10 25 0.0012 0.11 13.4 1.6 2 23 698 719 697 719 0.97

11 25 2.6e-06 0.00025 21.8 2.6 1 23 727 749 727 749 0.99

12 25 0.0044 0.42 11.6 1.9 1 23 902 924 902 925 0.95

13 25 0.01 0.99 10.4 0.5 2 22 933 953 932 953 0.95

14 25 0.073 6.9 7.8 2.2 1 23 962 985 962 985 0.93

15 25 1.8e-05 0.0018 19.1 1.2 2 23 1008 1029 1007 1029 0.97

16 25 0.00014 0.014 16.3 1.2 1 23 1036 1058 1036 1058 0.98

17 25 0.009 0.86 10.6 0.0 2 21 1085 1104 1084 1105 0.93

18 25 0.012 1.2 10.2 3.9 1 23 1151 1174 1151 1174 0.96

19 25 0.0069 0.66 11.0 0.5 1 23 1211 1234 1211 1234 0.96

20 25 0.0003 0.028 15.3 1.5 1 23 1258 1281 1258 1281 0.97

21 25 5.6e-06 0.00054 20.7 0.2 2 23 1309 1330 1308 1330 0.95

22 25 0.00016 0.015 16.2 2.9 1 23 1336 1358 1336 1358 0.99

23 25 3.8e-06 0.00036 21.3 2.0 1 23 1364 1386 1364 1386 0.97

24 25 2e-07 1.9e-05 25.3 2.4 1 23 1392 1414 1392 1414 0.99

25 25 0.0013 0.13 13.2 0.1 1 21 1420 1440 1420 1444 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	25	0.0019	0.18	12.7	1.1	1	23	215	237	215	237	0.96
2	25	0.033	3.1	8.9	1.7	1	23	243	265	243	265	0.97
3	25	0.049	4.6	8.3	2.1	2	23	297	318	296	318	0.97
4	25	9e-05	0.0086	16.9	1.6	1	23	391	414	391	414	0.94
5	25	3.2	3.1e+02	2.6	1.3	2	22	422	442	421	442	0.95
6	25	0.54	52	5.0	1.5	1	23	451	473	451	473	0.97
7	25	0.23	22	6.2	0.2	3	23	485	505	483	505	0.96
8	25	0.0085	0.81	10.7	1.2	1	23	587	610	587	610	0.97
9	25	0.0039	0.37	11.8	0.2	2	22	620	640	617	640	0.90
10	25	0.0012	0.11	13.4	1.6	2	23	698	719	697	719	0.97
11	25	2.6e-06	0.00025	21.8	2.6	1	23	727	749	727	749	0.99
12	25	0.0044	0.42	11.6	1.9	1	23	902	924	902	925	0.95
13	25	0.01	0.99	10.4	0.5	2	22	933	953	932	953	0.95
14	25	0.073	6.9	7.8	2.2	1	23	962	985	962	985	0.93
15	25	1.8e-05	0.0018	19.1	1.2	2	23	1008	1029	1007	1029	0.97
16	25	0.00014	0.014	16.3	1.2	1	23	1036	1058	1036	1058	0.98
17	25	0.009	0.86	10.6	0.0	2	21	1085	1104	1084	1105	0.93
18	25	0.012	1.2	10.2	3.9	1	23	1151	1174	1151	1174	0.96
19	25	0.0069	0.66	11.0	0.5	1	23	1211	1234	1211	1234	0.96
20	25	0.0003	0.028	15.3	1.5	1	23	1258	1281	1258	1281	0.97
21	25	5.6e-06	0.00054	20.7	0.2	2	23	1309	1330	1308	1330	0.95
22	25	0.00016	0.015	16.2	2.9	1	23	1336	1358	1336	1358	0.99
23	25	3.8e-06	0.00036	21.3	2.0	1	23	1364	1386	1364	1386	0.97
24	25	2e-07	1.9e-05	25.3	2.4	1	23	1392	1414	1392	1414	0.99
25	25	0.0013	0.13	13.2	0.1	1	21	1420	1440	1420	1444	0.91

Sequence Information

Coding Sequence: ATGCTGCCCAGCAATATTTGCCGTACGTGTGCCTTGCAGAACAGCAATTTGCTGCCCCTGTCCACGTCCTTGGACAAGTACACGAATAAAAGCTTCTACGATGTGCTCCAAGAACTGACTCAGATCGATCCCCTGCTCGAGAATGCTGACGACAATCTGCCCCAGCACCTGTGCACAGATTGCTTGGACAGGCTGGAGAATGCCTACGCCTTTGTGGAGCAGGCCAGAAAAGTCAATGGAGAGCTGCTGGTGCGGCTGCGGGAATGTCTGGAGGAGAGCCCCATTGACATACCAAAGCAGCAGATTAAAACGGAGATCGACATTGATGAGGAGCAAAGAGATTTCACTGATTCTGGCGAGGCACAAAGGTCGTctgatgtggatgtggagtCGGCTGGCGGGTGCTCCATTGAGCTGAAATGGACGCCACAAAGTGCCAGCGAGGAGGAAAATGCCAACGATGCCCTGTCAAACGATGAAGATGATGATGTGCAGCCCTATATCTTGAGGCGCAGTAACCGCAAAGTCAAGCAACTGGCAGACAGTGAAGAGGAGGAAGGAGTCAGTCCTTCGCCCAACAAGCGGCGTCGCGGACGTCCTCCCGGTCTGGCCAAAAGCCAGTCAAGGAATTCCGAAGGCCGTCATGCCTGTGAGGTGTGTGGCAAGACGTTTTCCTGGTTCCGGGACATGAAGCGACATGCTCGCGTCCATTACGAGAAGGCCTCGTTCGTCTGCGACACTTGTGGCAAGGGATTCCTGCGCAAGGACAAGTACACGTTCCATCTGCGCTCCCACGAGAAGCGGGAGGCCAAGTGCCAGGCCCTCCAGCTGAAGAACGAGTGGAGATTCGCCGAGCGTTTGTACAGCTCCGGGCGACTGAAGAGAATGCAGTGCAAATTGTGCGGCTTGAAATGCCAGCGAATGCAGGAGCTACGGTCCCATTTAGCGAGTCACATCCACACGGACAGCTTGTTCACTCTGCAAGCGGACAACGATGTGGTCAAAGAACATTTTGCCAGTGGGCCATTTGACCTGGAAAAGATCAAGCAGAAAATTTGCTTGGAAATAGCCGAAGGGCAGCTGGAAAAGTACTCTTCTGTGGTCAATTTCCATGGCTACGAGCTGTGCCTGAGCGATTCTGACGATGAGCCTGCCGGTGGAGAGCCACCGTACCGTTGTGACCTGTGCAATCTGTCGTTCACTCGCAAATATCGCCTGATGCGACACACCCTGGAGGAGCACACCCAATCGCCCATTTCGCAGCGCTGCAACCTCTGCAAAGTGGGTTTTGTGTGTGCAAAACTCTTCGAACAGCACCAGCGGACCCAGTGCCAGAGCAAAGGGAAGCGCTATCGTTGCCGCAAGTGTCCGGGGAAGTTCATGTGGCTGGAGAATCTGGAGCGGCATGCCTGCTCccatcgcaaggaggagcagTCATACAGGCAAATCATCTGTTGCCTGTGCGATGCCCAGCTTCCAAGCTTAAGGTCGCTGCGCGCCCACCTGGCCACCCATCGACATGGATTGAATGGCATTGATCCGGAGCAAAAGTCTGCCTTCTTCCGTTCTTACTATCCCAAGGGATTGGGCTGCAGCCTCTCTGAGCTGAGCTCCCGCATAGCTGGGGACTATGAGGCCCAGGACTTTGGACGCTACTACAACGCCTGTACGGGAAGTGGTCAAGAGCTGGATCTCTTCGACTCCGATACGGAGGAGAGCGATGATGCAGACAAAACGGAGGAAAAGCCGAAACCCTCGCACACCTGCCTGCTCTGTGGAGAGACTACTATTCGCCTGCTCAAGCTGCTGCAACATCAAAGGACACTCCACTCCGAAGAGGGCCCCACGTACCCCTGCTCTTGCCAGGATTGCGGCGCTGGCTTCGTCTCGGAACCCTTGCTTCAGCAACATCGCAGACGTTCCTGTGCCAAAAAGCACTCGAAATACCACTGCCAGCGATGCAATCTTCATTTTGTGTGGCAATCGAACCACGAGCAACATCTGCGATTGTACCACGACAAGGACGGGGATCAGGAGCAGTCGGAGGACTGCCAGCAGGGCAGAAAACATAAATCGTCGGCCGCCAAGCTTCAGTGCGATGAATGTGAAAAGGTCTTCATTTGGCACAAGGACCTCACCCGTCACAAGCGAATGCATCGCCCCCCGTCGGCAGCCCAATACGAGTGTGCCTATTGCGACCGCAAGTTCCACCGCAAGGATGGCCTCAAGTCCCACATGCGGGTTCacaacgagcagcagcaggagacgGGGAATGAGGAGCAGTCTTGCGTCCAATCGACCTCTACGAACAGTATTCAGAGACAGCCCGGGGAGCAGCTGGCCCAACTATGCCGTCCAAATGGCTGCAAGCAAATCCAGTGCATGATCTGCCTCTCGCGTCACTCGAAGATCGCCGATTTGAGGAATCACCTGAGCACGCACCAATATGGTGTGTGCTTTCCGCAGGAGACAGATGTTGCCAGTGCCTCGCGCTCGTTGTATCCGGAACTGGGCACTGCCCTGGAcaagcaggagctggagcagagGATCATGAGCGATGTGGCCAGCGGCTTGGAGTTGGAACGATTCATTTCCATAACCAACGAGGCTGGCCTGGAACTCTCTCTTGAGAGCAGTGAAACGGAAACGGACTCAGAGcaggacgaggacgacgagAGTTCCGAAGAAACGGACCAGCCGCGGTACGCCTGCAACATCTGCCAGGTGGAGGTGAGGCGGAAGCATCAATTGTATGCCCACCAGTTGGAGCATCACCAGTGGGAGGAGGCTTCGCTTGTGTGTGCCCACTGTCAAGCGAGATTCGTGAGTGAGACGCTGCTGGAGCATCACTACAGGACCCTCTGCCGGAACCAGCTGAAGCGTTTCCAGTGCCGAAAGTGTCCGCTACGCTTCCGCTGGCGGGAGAACCTGAAGCTGCACGCCAATGCCTGCCATCAGCAAAGAGGACAGCCCCAAGCTGCAGAGGAACAGAGAAACGGCGTCCAGGCTGAGTTCGAGCTCCAGTGTGGGGAGTGCAATCGCAGCTTCAAGATGCAGAAGGATCTCACGCGGCACACGCTGATGCATGCCCAGGCATCGAGCATTTATCGCTGTCGCTGGTGTGCCCGCCGCTTCTACAGGAAGGCCAATCTCCTGCAGCACATTGAGCGGCATGGCATCGGGGCTAGCCAGCTGCCGTACGCGGAAGCTCTCCTCAATGCCTATTGCCAGCCCAATGGCCAGAAGAGCGTCGAGTGCAAAGTGTGCAGCTTGAGCTTCTCCAGCATTGCTGCCCTTCGCGTCCATCTGGAGACCATGGCGTCGGGCAGTCACCACGAGCTCTCGTCCCTGCAGAACTACTCGATAACCAACCAAATGGGATTCGAGCTGCACTTGGACGACTCGGAGACGGACGAGGAGGAGTCCAAGCCACCGGGCACGCCTGCTTTCTACACCTGCGGCATGTGCCAGCTCCGGTGTGTGCGGAAGTACGAGCTGCATCAGCACCAGCAGGCCATGCACAGGCTGGAGAAGATCCCCGATGGCTGCGATCTGTGCATATTCAAGAGCGTCTCTCCCGATCTTATCGCGCATCACCAGCGAGTGCAGTGCCACAACCGGGAGAAGCAGTTCACCTGCGCCAAATGCGGCTACAAGTTCATGTGGGAGTCCAATCTCCTGCTGCACATGCAGCTGCAGCATGGCAAGACCGAAGAACAGGATGATCCACCTCTGGATGAGCCCGTGGAGCAGAAGACTGTGTGTCCAATCTTCCAGTGCGGCCTCTGCCCAAGAAAATACAATCGCAAGGATCGACTGACGGCCCATGTGAAGAAGTTCCACAACCCAGTGGAAGGGAGCGCTCCGAGCGCCATACGGGCTGCTCCCGTCCGGCCAACGTCGCCCAAGGAGCCGAAACGCTTCCTTTGCGCCTTCTGTGGCAAGGCTGTGAGCTCCTCCTCCAACCTCATCATCCACATGCGGCGGCACACGGGCGAGAAGCCTTTCAAGTGCGACTACTGTGAAATGGCCTTTCCGCGCTCCTCCGATCTCCAGTGCCATCGACGAACGCACACCGGCGAGCGGCCCCACATCTGCACCGTCTGCCAGAAGGGCTTCGCCAGATCCTACAAACTGCAGCAGCACATGCGCATCCACAACGGCGAACGGCCCTACAAGTGCACCTACTGCGAAAAGAGCTTCACCCAGTCCAACGACCTGACACTCCACATCCGCCGCCACACGGGCGAGCGTCCCTATCAGTGCGGGGTCTGTGGTGAGCGTTTCATCCAGGGCACGGCCTTGAAGAATCATCGCCTGCAGCAGGGCCACTATGACGAGGCCAGCCAAGGAGCGGCAGAGTCCTCAAGGCGAACGGTCCTAGAGCAATTTACAGTTTAG
Protein Sequence: MLPSNICRTCALQNSNLLPLSTSLDKYTNKSFYDVLQELTQIDPLLENADDNLPQHLCTDCLDRLENAYAFVEQARKVNGELLVRLRECLEESPIDIPKQQIKTEIDIDEEQRDFTDSGEAQRSSDVDVESAGGCSIELKWTPQSASEEENANDALSNDEDDDVQPYILRRSNRKVKQLADSEEEEGVSPSPNKRRRGRPPGLAKSQSRNSEGRHACEVCGKTFSWFRDMKRHARVHYEKASFVCDTCGKGFLRKDKYTFHLRSHEKREAKCQALQLKNEWRFAERLYSSGRLKRMQCKLCGLKCQRMQELRSHLASHIHTDSLFTLQADNDVVKEHFASGPFDLEKIKQKICLEIAEGQLEKYSSVVNFHGYELCLSDSDDEPAGGEPPYRCDLCNLSFTRKYRLMRHTLEEHTQSPISQRCNLCKVGFVCAKLFEQHQRTQCQSKGKRYRCRKCPGKFMWLENLERHACSHRKEEQSYRQIICCLCDAQLPSLRSLRAHLATHRHGLNGIDPEQKSAFFRSYYPKGLGCSLSELSSRIAGDYEAQDFGRYYNACTGSGQELDLFDSDTEESDDADKTEEKPKPSHTCLLCGETTIRLLKLLQHQRTLHSEEGPTYPCSCQDCGAGFVSEPLLQQHRRRSCAKKHSKYHCQRCNLHFVWQSNHEQHLRLYHDKDGDQEQSEDCQQGRKHKSSAAKLQCDECEKVFIWHKDLTRHKRMHRPPSAAQYECAYCDRKFHRKDGLKSHMRVHNEQQQETGNEEQSCVQSTSTNSIQRQPGEQLAQLCRPNGCKQIQCMICLSRHSKIADLRNHLSTHQYGVCFPQETDVASASRSLYPELGTALDKQELEQRIMSDVASGLELERFISITNEAGLELSLESSETETDSEQDEDDESSEETDQPRYACNICQVEVRRKHQLYAHQLEHHQWEEASLVCAHCQARFVSETLLEHHYRTLCRNQLKRFQCRKCPLRFRWRENLKLHANACHQQRGQPQAAEEQRNGVQAEFELQCGECNRSFKMQKDLTRHTLMHAQASSIYRCRWCARRFYRKANLLQHIERHGIGASQLPYAEALLNAYCQPNGQKSVECKVCSLSFSSIAALRVHLETMASGSHHELSSLQNYSITNQMGFELHLDDSETDEEESKPPGTPAFYTCGMCQLRCVRKYELHQHQQAMHRLEKIPDGCDLCIFKSVSPDLIAHHQRVQCHNREKQFTCAKCGYKFMWESNLLLHMQLQHGKTEEQDDPPLDEPVEQKTVCPIFQCGLCPRKYNRKDRLTAHVKKFHNPVEGSAPSAIRAAPVRPTSPKEPKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCDYCEMAFPRSSDLQCHRRTHTGERPHICTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNHRLQQGHYDEASQGAAESSRRTVLEQFTV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00471775;
90% Identity: iTF_00580900;
80% Identity: -