Basic Information

Insect: Drosophila guanche
Gene Symbol: ken1
Assembly: GCA_900245975.1
Location: NW:3185919-3188431[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.0032 0.19 11.8 2.0 3 23 204 224 202 224 0.93

2 12 0.0017 0.1 12.6 0.1 1 23 230 255 230 255 0.92

3 12 0.045 2.6 8.2 0.1 3 23 264 287 262 287 0.93

4 12 0.005 0.3 11.2 2.3 2 23 300 321 299 321 0.96

5 12 8.4e-06 0.0005 19.9 0.6 1 23 328 350 328 350 0.98

6 12 0.0021 0.12 12.4 0.2 1 23 356 378 356 378 0.98

7 12 0.0056 0.33 11.1 2.0 1 23 384 407 384 407 0.97

8 12 0.009 0.53 10.4 4.0 1 23 413 435 413 435 0.96

9 12 0.00076 0.045 13.8 2.9 2 23 442 463 441 463 0.96

10 12 9.7e-05 0.0057 16.6 1.2 3 23 554 575 552 575 0.95

11 12 0.0027 0.16 12.1 1.1 1 19 581 599 581 603 0.95

12 12 3.6e-06 0.00021 21.1 1.0 1 23 609 631 609 631 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.0032	0.19	11.8	2.0	3	23	204	224	202	224	0.93
2	12	0.0017	0.1	12.6	0.1	1	23	230	255	230	255	0.92
3	12	0.045	2.6	8.2	0.1	3	23	264	287	262	287	0.93
4	12	0.005	0.3	11.2	2.3	2	23	300	321	299	321	0.96
5	12	8.4e-06	0.0005	19.9	0.6	1	23	328	350	328	350	0.98
6	12	0.0021	0.12	12.4	0.2	1	23	356	378	356	378	0.98
7	12	0.0056	0.33	11.1	2.0	1	23	384	407	384	407	0.97
8	12	0.009	0.53	10.4	4.0	1	23	413	435	413	435	0.96
9	12	0.00076	0.045	13.8	2.9	2	23	442	463	441	463	0.96
10	12	9.7e-05	0.0057	16.6	1.2	3	23	554	575	552	575	0.95
11	12	0.0027	0.16	12.1	1.1	1	19	581	599	581	603	0.95
12	12	3.6e-06	0.00021	21.1	1.0	1	23	609	631	609	631	0.98

Sequence Information

Coding Sequence: ATGGATATGGTCGCACGGGAGCCATATCCCGTCCACTCACTGTGCCGCCTCTGCCTGACGTGCCTGGAGCAAGGCCCCGCCCACGATCTGTTTCTGGAGCCAGATCTGGCAAAAAAGCTAACCCTCTGCACCGCTCTGGATGTGGACCAGCAGGATGGCTTTCCCCGGAGCATATGCAATGGATGCTTTGGGCAGCTAAGCGATCTGCAAGCGTTCCAAAAACTATGCCTGGACTCTGTGCAGCGTTTCAAGGATATGGTGGCTGCCAACAGAATTGTGGCCATCGAATTGTTGGAGCCGGTGGCCGAGCAGCCAGCGGAGGTGATTTTGGGCCCTGAGGAGCAGGCAAGCTATGATCCCCTGCTGAATCACAAGTTGGAGATGATTGAGAACGAGGAGGAGGTCTTCAAGATGCTGGTGACGGTGGACAAGAGCGTTTTCTCCGACTTCACGAGCGTGGAGaacgatgacgaggaggaggaggaggaggagatacCGGATGGCTCCACCGACGACGAAATTCCATTGGCCCATCGTTTGCTGTCCAAGGAGCGGGCAAAGCGAAAAAAGATACCACCTGAAGAGCGTCGCCTGCGTCGTATCATCACCTGCATCATCTGCCAGAAAAAGTTCAAGAAACAATCGAAATTCGATGAACACATGAAGTACCACAACGATCTGCTGCCCTTTCAGTGCTCGGAGGAGACCTGCCGGAAGGGCTTCACCACAGCCGGTGCACTGCGTCTGCATGTGGACTATGCGCACACGAGGAAAGCCGATGAGATACCGTGCACCGTGGAGGGCTGCAAGCTGCTGTTTCCCCGTCTGCGGCTGCTCACCATTCACCTGAAGAAGGTGCACAATCAGACGCGGGTGAGTGCACCGCGTGCGGAGCAGCCCTGTGGCGAGTGTGGAATGGTCTTTCGCTGTCATGTGGCCCTCAAGAAGCACATGTACAAGCACACGGGCGAGGAGCTGCCCTACCCCTGCAACATCTGCGGCAAAGGATTCCACATCAATAGCGCCTTGAAGAACCATCTGCTGCGACATGCGGGCATCAAGAACTACGTCTGCCCCTACTGCGGCGTGGGCAAGACGACGCGCCAGGAGTGGAGCAAGCACATGCTGACCCACACCCAGGAGAAGCAGTTCAAGTGCCCCACCTGCGACCATGCCACGCACACAAAGCGAGCGCTGGACAATCACGTGAAGATCGTTCACGAGAAGGTCCGCAACTTTGCCTGCCAGTACTGTGGGAAGACGTTCGGCAAGTCACATGCCTGCAAGATCCACGAGATGACGCACACGGGAGAGAAGCGCTGCGAGTGCAAGGTCTGTGGCAAGAAGTTCCTCTACACCGAAAGCCTCACGAAACACCTGAAGATCCATGAGAAGAGCGTGGAGCGTGCCTTGGAGACGTATCGCCAGCGGCAGGGAGAGACGACCAGCGCTGACCAGGACCAAGTGCAAGTGGATGCCAATCACCTGATAAAAGTCTGCGCGGAATCGGTGGCCACAATTCCGAGGGATCCGCGACGCGTAGAGCGCGTTGATATGGCCCAGCTGGctggcactgtggtgaatcccATACCCATCGTCTCAGTGCCATCCAGTGTGCCGCCCCAAGCGAAGTTCGTGCAGAAGGAGGGCATGCATCTGTGTCCGGGCTGCAATCAGGGCTTCAACAATCTGGGCAACATGAAGCGACACTACAAGAGCATACACGAGAAGGTCAAAGACTTTGAGTGCCGCTTTTGTTCGCGTCGCTTTGCCAATTCGCAGTCGCTCAAGCAGCACGAGTGGATACACACGGGCGAGAAGCCCTACGCCTGCAAGACCTGCGGCACACACTTCCGACAGGAGGCGGCTCTCATACGCCACCAAAAGGTGCACGACGAAAAGCCACCACGGCCAGCGAAGCCGCCCAAGGAAATCACAGACAAGGCGCGCCAGAAGCTGATGCAGAGGTCCGAGCGCAAGCGTGAGGTGGAGGCGCTGCGCCAGGAGATAGCCCAGGCCGCCAAGGAGGAACTGAAAGACCTGGAAAAGCAGCGGGCActggagaaggagcagaatACCTATGAAAAGTatcaggcagcggcagaggcaactTGA
Protein Sequence: MDMVAREPYPVHSLCRLCLTCLEQGPAHDLFLEPDLAKKLTLCTALDVDQQDGFPRSICNGCFGQLSDLQAFQKLCLDSVQRFKDMVAANRIVAIELLEPVAEQPAEVILGPEEQASYDPLLNHKLEMIENEEEVFKMLVTVDKSVFSDFTSVENDDEEEEEEEIPDGSTDDEIPLAHRLLSKERAKRKKIPPEERRLRRIITCIICQKKFKKQSKFDEHMKYHNDLLPFQCSEETCRKGFTTAGALRLHVDYAHTRKADEIPCTVEGCKLLFPRLRLLTIHLKKVHNQTRVSAPRAEQPCGECGMVFRCHVALKKHMYKHTGEELPYPCNICGKGFHINSALKNHLLRHAGIKNYVCPYCGVGKTTRQEWSKHMLTHTQEKQFKCPTCDHATHTKRALDNHVKIVHEKVRNFACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYTESLTKHLKIHEKSVERALETYRQRQGETTSADQDQVQVDANHLIKVCAESVATIPRDPRRVERVDMAQLAGTVVNPIPIVSVPSSVPPQAKFVQKEGMHLCPGCNQGFNNLGNMKRHYKSIHEKVKDFECRFCSRRFANSQSLKQHEWIHTGEKPYACKTCGTHFRQEAALIRHQKVHDEKPPRPAKPPKEITDKARQKLMQRSERKREVEALRQEIAQAAKEELKDLEKQRALEKEQNTYEKYQAAAEAT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00536218;
90% Identity: iTF_00601216;
80% Identity: -