Dgua004997.1
Basic Information
- Insect
- Drosophila guanche
- Gene Symbol
- Lztr1
- Assembly
- GCA_900245975.1
- Location
- NW:404950-410154[+]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 5.2e-13 9.7e-11 41.4 0.2 1 108 575 716 575 718 0.89 2 3 0.45 85 2.9 0.1 78 108 718 748 714 750 0.90 3 3 2.9e-19 5.3e-17 61.5 0.0 8 97 809 898 803 913 0.85
Sequence Information
- Coding Sequence
- ATGCTAAAATCCATCAGCGgaggcgttggcgttggcgtggccggggcaggagcaggtgcGGCTGCcagtggcggcggtggtggtggtggcgcaggaggaggagtcatcgcaggagcaggagcaggagctgcagtgGGGAGCGGGACAGGTAGGAGTGGGAGTGCCACTGCGAGCGGAAGTGGAAGCGCGGGCGCTAGTGGAAGTGCCAACACAGTTGGGAGCGTCCGTGCCAGTTGTGGCATTGGCTCCAATTCGATATCCAGCGGCCTGAGCGCCGTTTGTGGCTTGGTCACCGGCAGcggtagtggcagtggcagcggcagtggcagtgccagcggTAGCGGAGGCAGCACCCCCGCCGGAGTCAACATCTACTGTCCGGCCTgtgtggccagcagctcgcagcagcagcaccagacaCCGTCGCAGGCGGCACCCCACTCCGAGTCGTTCTTTTCGCGCTCAAAGTCGAGCAAGCGGCACAAGGCCAGGAAGAGCGCCTCCACCGCCGGTTGTCTGGACGCCCAGCACATTCGCAACAACCTGAGAATGTCCACCTCCAGTTCGCTGCGCAGCACGCGCGCCGTCCAGTCgagccactgcagcagcagcagcccggcCTACGATGCGGCCAGCAAtgccagcaatggcagcagtggcagcggcacagcCGCCTCGCCGGGCAGCTACAGCTGCAACGCGCTCAACGTGGACTTCACCTCGTACACGGCCACGCACCAATGGACCCGGATGCTCGAGTGTGCCGAGTTTGTGGGCGCCAAGCGCAGCAAGCACACGGTGGTGGCCTACAAGGATGCCATGTTCGTGTTTGGCGGCGACAATGGCAAGAACATGCTGAACGACCTCATACGCTTTGGCGTGAAGGACAAGTCGTGGGGCAGGGCGTGCGCCACTGGGACACCGCCAGCGCCGCGCTACCATCACTCGGCGGTGGTGGCCGGCGCCTCGATGTTCATATTTGGCGGCTACACGGGCGACATACACTCCAACTCGAATCTGACCAACAAGAACGATCTGTTCGAGTACAAGTTCAAGAGCGCCATGTGGGTGGAGTGGAAGTTCTCGGGCCGGCAGCCAGTGCCGCGCTCTGCCCACGGTGCGGCCGTCTACGACAACAAGATGTGGATCTATGCGGGCTACGACGGCAATGCCCGACTGAATGATATGTGGACGCTCAACCTGACCGACGACCACCATCAGTgggaggaggtggagcagaAGGGCGACAGGCCGCCCACCTGCTGCAACTTTCCGGTGGCCGTGGCCCGGGATGCCATGTATGTGTTCTCGGGGCAGAGCGGGCTGCAGATCACCAATTCGCTGTTTGAATTCCACTTTAAGACGCGCACCTGGCGTCGCATCTCGAATGAGCCGGTGCTGCGTGGCGCCACCTCGGCGCCGCCCCCTCGCCGCTACGGCCACACCATGGTGCACCACGATCGGTTCTTGTACGTGTTCGGAGGCTCCGCAGACTCGACGCTGCCCAACGATCTGCACTGCTACGACCTGGACCTGCAGATCTGGTCCGCTGTGCTGCCGGAACAGAACTCGGACGTTCCCTCGGGCCGGGTGTTTCACGCCTCGGCCGTCATCGGCGATGCCATGTACATCTTCGGCGGGACCGTGGACAATAGCGTGCGGCGCGGCGACACCTACCGCTTCCAGTTCTCCAGCTATCCAAAGTGCACGCTGCGCGACGACTTTGGCAAGTTCTTTCAGGAGAAGCAATTCTGCGACATTGAGTTCGTGGTGGGTGTGGAGGAGGTGCGCATTCTGGCACACATTGCCTTCGTGGCGGCACGCTCCAAGTACTTGCGCAACAAGATATTGGCCGCACGCGAGGCacgccagcagcagatggagaAGGTTTACGGCGTTGGCCAGGTGGATGCGCAGGCGCTGAACACGGGCGTTGGCGGTGACCGGGCACCCATGCTGGAGGTGCGCCTGGTGCACGCCTCGCCGGAGGCCTTTGACATTATTCTCAACTACATCTACACGGATCGCATCGACCTCAAGGATCCGTACAACAAGAACATAATCATTCTAATCACCGACATCTACCAATTGGCTGGGCTCTTCACCATGCCGCGGCTGGCCCACGGCTGCATACAATATCTGGACTATAAGATCAACAAAATCAATGTCCTAGAGGCCCTCTACAATGCGGATAAGAGCAACATCAAAATAATCAAGGATCACTGCATGCAGTTCATCATCAAGGAGGAGAACTTCACCGAGGTGGTCATGTCCAGTGAGTTCAGTGACCTGGACAAGCCCCTGCTCGTGGAGATCATACGCAAGCGTCTGCATCCCAGCAAGCTGGTAATGGACACCAGTTTCGAAGCGAGCACAGGCACCACATTGGAGCTGGATCTGTGCACGTTCCTGAAGACGACCGGCAATGATTTCTGCGACATTAGCCTTATATTGGAGGACCATGTGATACCGGCGCACAAGTCTGTGTTGTCGTCACGCTGTACCTATTTCCAGGGCATGTTCCGTTCGTTCATGCCGCCGGATAACACCGTCAATATACAAATTGGTGAGATTTCACCCTCATTGGAGGCGTTTCATTCACTGCTCCGCTACATCTACTACGGGGAGACAAAGATGCCGCCACAGGATGCGCTGTACCTGTTCCAGGCACCGTGCTTCTATGGCCTGTCCAACAATCGTCTGCACGCCTTCTGCAAGTACTCGCTGGAGCATAATATTACGTACGAGAATGTGCTGCAGACGCTGGAAGCGTCGGATATAACGAAGATCTACGACATCAAGGAGTATGCGTTGAAATTGATTGTGAAAGATTTTGCCAAGGTGGCAAGACTGCCAAAGATATCGGGTTTGTCGCGCGAACTGTTGCTGGAGATCATACGCGCTGTGGCCGATTCGCAAGGCGAGTTTCTGACCAGCATTAATATCAATACAGATATCTGA
- Protein Sequence
- MLKSISGGVGVGVAGAGAGAAASGGGGGGGAGGGVIAGAGAGAAVGSGTGRSGSATASGSGSAGASGSANTVGSVRASCGIGSNSISSGLSAVCGLVTGSGSGSGSGSGSASGSGGSTPAGVNIYCPACVASSSQQQHQTPSQAAPHSESFFSRSKSSKRHKARKSASTAGCLDAQHIRNNLRMSTSSSLRSTRAVQSSHCSSSSPAYDAASNASNGSSGSGTAASPGSYSCNALNVDFTSYTATHQWTRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGASMFIFGGYTGDIHSNSNLTNKNDLFEYKFKSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLTDDHHQWEEVEQKGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPPRRYGHTMVHHDRFLYVFGGSADSTLPNDLHCYDLDLQIWSAVLPEQNSDVPSGRVFHASAVIGDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQEKQFCDIEFVVGVEEVRILAHIAFVAARSKYLRNKILAAREARQQQMEKVYGVGQVDAQALNTGVGGDRAPMLEVRLVHASPEAFDIILNYIYTDRIDLKDPYNKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINKINVLEALYNADKSNIKIIKDHCMQFIIKEENFTEVVMSSEFSDLDKPLLVEIIRKRLHPSKLVMDTSFEASTGTTLELDLCTFLKTTGNDFCDISLILEDHVIPAHKSVLSSRCTYFQGMFRSFMPPDNTVNIQIGEISPSLEAFHSLLRYIYYGETKMPPQDALYLFQAPCFYGLSNNRLHAFCKYSLEHNITYENVLQTLEASDITKIYDIKEYALKLIVKDFAKVARLPKISGLSRELLLEIIRAVADSQGEFLTSININTDI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00479535;
- 90% Identity
- iTF_00603400;
- 80% Identity
- -