Deug009041.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila eugracilis
Gene Symbol
-
Assembly
GCA_018153835.1
Location
NW:1032363-1037314[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.17 11 6.4 0.1 3 23 275 296 274 296 0.91
2 10 5.1e-05 0.0032 17.5 0.3 6 23 305 322 305 322 0.99
3 10 1.2e-05 0.00075 19.5 0.3 1 23 328 351 328 351 0.98
4 10 0.00028 0.018 15.1 0.4 1 23 363 385 363 385 0.97
5 10 0.014 0.88 9.8 5.6 1 23 392 415 392 415 0.97
6 10 1e-05 0.00066 19.7 1.8 1 23 421 443 421 443 0.96
7 10 0.074 4.7 7.5 0.4 2 23 452 473 451 473 0.96
8 10 6.9e-05 0.0044 17.1 2.3 2 23 479 501 478 501 0.95
9 10 5.1e-06 0.00032 20.6 0.9 2 23 508 529 507 529 0.96
10 10 0.00016 0.01 15.9 4.4 1 23 535 558 535 558 0.96

Sequence Information

Coding Sequence
ATGATTTGTCGCTTGTGCCTGCGGTGTCTTAGTCCCGGCAGCGCCGTCTTCCTTTTCGAGACGGATGATACGCTGGCGGAGACGCGCTTGGTTAAGATGATCGCCAAGTTTCTGCAGCTGGAGATCCTGCCCGATGACGGTATCTCGACTAGCGTCTGCACCGACTGCTGCGAGCACTTAGAGGACTTTAACGGTTTCTGGCAGTTGGTGGAACAGAAACAGTGTTCGCTGAAGAAAGAATTCCTCACCGTGGACGTTGACTGTGTGGCGATTAAATGGACGGGTGGTGTAGATGTAGACGTCAACATCGACGAGCTGCCGCTGGCGGCTGGCGACATGGATGAAAAGCCACTGGACCTGCACAACCTCAGTCTGCTGGGCAGCGTATTGGACGTAAATGTGGACAGTGTAGACGTTAGGGAGCAGGTCAAGGAACAGCTGACCTGCGAGTCCGAGAAAGAGGACGAAAAGCCCTGCCTGCAGGCCAGTGACAGCGAGACGGAGCCGCCTGAGACGCAGTTAGAAGACGACTCTTCGGATGATGAGCCCCTGGTCCGTCTGCAAACCAAGATGAAACCAAAACGCAAGGTCTCGGGTCGTTCCTCTAAGGATGAGGGTCCTGTTTCTCTGCATCGCGAGCTCGCCGACCTACTCGACGATGGCTGCAAGCGTCGACGCAGAAAGGCATCTGGCCAGCGAGCACCCACCGAAGTGCAAGAATCCGAGCTGCAGGCCGTCCTTGAGCGCAAGCCCAAGGGTTGCTCGCGCGCTCAGCTAGCCAAAAGCTACGAGGAGGCCATTGCCAGCTACATGAGCGCCAACTGCGATCTGTGCGATTTCAGCGCTCCTTACCTGTCTGAGCTAAAGACGCACTTTCTGGAGGCGCATCAACGCGAGTACTACATAAAATGTTGTGGCAAAATCTTCACGCGCGCTTCCAAGCTGATGGACCACATCCGCAAACATGTTAACCCCAAGTTATTCACCTGCACCATTTGTCAAAAGTCGCTGAACTCGCAGGACTACCTGGCCACCCACATCGAGACTGTGCACAACAAGGTCGCCCAGATAGACAAGGTGCTCAAGTTCCCCTGCCCCAAGTGCGAGCGCACCTTCAGTAGCGAACGTCGAATGGCCAATCACTTAGCCAAGCACGACACCGACCAACTGGAACACACCTGCGAAATCTGCTGCAAAAGCTTTGCCAATATACACAGGCTACGGCGGCACATCCAATCCATCCATGAGGACCTGCACCGTCATGTTTGCGATATCTGCGGCaagaagtttaagtttaagccCTCCTTTGAGCGTCATTTGCTGGAGCATCAGGGTGTGGTGGCGCCGGCAGTGGAGTGTCCAGTGTGCGGAGTGTGGCTGAAGAACGAGCATAGCTTACGCCTTCACCGCTTTACACACGACAGCACAGACACTGTGTGTCCGCACTGCGGCAAGACATGTACCTCACGTACTGCGCTCCGGGGTCATGTGAAATATGCCCATAAGTTGACCACCAATCTGCAGTGCACGTTTTGCGAGAAAACCTTCAAGCAACAGCGCAACCTGGACGAGCACATGGCCATCCATACGGGCCTGCAGCTGTACAACTGCCCGCATTGCCCGAAGGAGTGCCGCTCCCGCTCTAACATGTACGTCCACATCAAGCAGCGGCATGCGGACGAATGGCTTCGCGCCAAGATGGCGCGTTCGCACAATCCCCAATTCAAGCCGGGATCCACCGACGTTTAA
Protein Sequence
MICRLCLRCLSPGSAVFLFETDDTLAETRLVKMIAKFLQLEILPDDGISTSVCTDCCEHLEDFNGFWQLVEQKQCSLKKEFLTVDVDCVAIKWTGGVDVDVNIDELPLAAGDMDEKPLDLHNLSLLGSVLDVNVDSVDVREQVKEQLTCESEKEDEKPCLQASDSETEPPETQLEDDSSDDEPLVRLQTKMKPKRKVSGRSSKDEGPVSLHRELADLLDDGCKRRRRKASGQRAPTEVQESELQAVLERKPKGCSRAQLAKSYEEAIASYMSANCDLCDFSAPYLSELKTHFLEAHQREYYIKCCGKIFTRASKLMDHIRKHVNPKLFTCTICQKSLNSQDYLATHIETVHNKVAQIDKVLKFPCPKCERTFSSERRMANHLAKHDTDQLEHTCEICCKSFANIHRLRRHIQSIHEDLHRHVCDICGKKFKFKPSFERHLLEHQGVVAPAVECPVCGVWLKNEHSLRLHRFTHDSTDTVCPHCGKTCTSRTALRGHVKYAHKLTTNLQCTFCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHADEWLRAKMARSHNPQFKPGSTDV