Basic Information

Insect: Drosophila eugracilis
Gene Symbol: L
Assembly: GCA_018153835.1
Location: NW:331601-339527[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 1.1e-05 0.00068 19.6 3.1 1 23 154 176 154 176 0.98

2 17 0.13 8.3 6.8 7.3 1 23 182 204 182 204 0.97

3 17 1.4e-07 9.2e-06 25.5 3.2 1 23 210 232 210 232 0.99

4 17 1.1e-05 0.00067 19.6 0.4 1 23 238 260 238 260 0.99

5 17 0.01 0.66 10.2 0.2 2 23 339 363 338 363 0.92

6 17 0.0033 0.21 11.8 0.2 2 23 382 404 381 404 0.95

7 17 0.053 3.3 8.0 0.7 1 23 488 510 488 510 0.97

8 17 0.003 0.19 11.9 0.1 2 23 518 539 517 539 0.91

9 17 2.7e-05 0.0017 18.4 0.5 1 23 547 571 547 571 0.95

10 17 4.3 2.7e+02 2.0 0.9 2 23 607 629 606 629 0.94

11 17 0.0022 0.14 12.4 1.1 1 23 674 697 674 697 0.97

12 17 0.0042 0.27 11.4 1.2 2 23 878 900 877 900 0.96

13 17 0.034 2.2 8.6 0.1 1 23 906 928 906 928 0.92

14 17 0.041 2.6 8.3 0.1 2 23 936 957 935 957 0.96

15 17 0.63 40 4.6 0.5 2 23 1055 1076 1055 1076 0.94

16 17 0.017 1.1 9.6 0.0 1 23 1086 1108 1086 1108 0.95

17 17 4.2e-05 0.0027 17.7 1.5 1 23 1115 1137 1115 1137 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	1.1e-05	0.00068	19.6	3.1	1	23	154	176	154	176	0.98
2	17	0.13	8.3	6.8	7.3	1	23	182	204	182	204	0.97
3	17	1.4e-07	9.2e-06	25.5	3.2	1	23	210	232	210	232	0.99
4	17	1.1e-05	0.00067	19.6	0.4	1	23	238	260	238	260	0.99
5	17	0.01	0.66	10.2	0.2	2	23	339	363	338	363	0.92
6	17	0.0033	0.21	11.8	0.2	2	23	382	404	381	404	0.95
7	17	0.053	3.3	8.0	0.7	1	23	488	510	488	510	0.97
8	17	0.003	0.19	11.9	0.1	2	23	518	539	517	539	0.91
9	17	2.7e-05	0.0017	18.4	0.5	1	23	547	571	547	571	0.95
10	17	4.3	2.7e+02	2.0	0.9	2	23	607	629	606	629	0.94
11	17	0.0022	0.14	12.4	1.1	1	23	674	697	674	697	0.97
12	17	0.0042	0.27	11.4	1.2	2	23	878	900	877	900	0.96
13	17	0.034	2.2	8.6	0.1	1	23	906	928	906	928	0.92
14	17	0.041	2.6	8.3	0.1	2	23	936	957	935	957	0.96
15	17	0.63	40	4.6	0.5	2	23	1055	1076	1055	1076	0.94
16	17	0.017	1.1	9.6	0.0	1	23	1086	1108	1086	1108	0.95
17	17	4.2e-05	0.0027	17.7	1.5	1	23	1115	1137	1115	1137	0.98

Sequence Information

Coding Sequence: ATGATGGCCCTAAAGATGTTATATCGCGGTCCCAGTTCGCGTTTGGAGAATTTAATCGAAAAGATCCAGGCCACCAAGGAGATATCCAATAACGATATGTACAGTACCCACACATCGTCCAGTTACTCCCCAAGCATTTCTGACGGCACAATGACACCCAATTCCCACCACTTACCTGGCGCTCCCAACACCGCTGGTCACGAGGATCATCCAGCTGAGGGCAAAGTAAATGGTGGCACCGATGGCGATGAGTTACCGAAGCCAAAACGTTTGCCGCACttccatcatcatcaccaccaTCACTATCATCATCAACAGGCGCTGAAAATAGCCAACAAGCTGCGCAAAATCAATAAGGAAGCCAAAATGGGAGCTACCGCAGGTGCGGGATCCACAGGAGCAGGCTCCAAGTTTGATAAGTTGACAGGGGAGGGGATTAAAAGTCGCGGCGACGGCTCCTATCAGTGCCAGTTCTGCGACAAGACATTTCCACGTCTTGGCTACTTGAAGCATCATGTACAGaGCCACGCCGAACACCTGCCTTTCAAATGCGAATACTGCTCCAAGCTCTTCAAGCACAAGCGTTCCCGAGATCGTCATAAGAAGTTGCATACCAACGAGCGGAACTACAAGTGTCCACATTGCGAGGCAGCCTTTTCCAGGAGTGACCATTTGAAGATCCACATGAAGACCCATGACATCCAGAAGCCCTTCCAGTGCAGCATGTGCAACCGGGGCTATAATACAGCCGCTGCTCTCACCTCTCACATGCAGAAGCACAAGAAGAATGCAGCCATCCTGGCAGCTGGTGGTAATCCTAATGCCCTGAACTACAGTCCACGATCCACGGGATCTGCCTCGGCCTCGGTGTCTAGTAATGGCAGCCTGCAAAAAAGGAGATATGCCTTGGCTTTGGCCTCAGATAGTAGTCCAAGCAGATTGGATTTCCCCAAGAGATCGAGAAGTAGTCATGTGGGTGGCACTACCACCACAGCCACTCCCACTCCTCTACTACGATGCAGTTATTGCCCCAAGGTCACGGAGTTCAGTAGTCTGGAGCAACTGAATGCCCATCTCCAGAGTGTACATGAGCAACCGCAGGCTGTGAAGACTCCAGTCCAAGAGGGCGAAGGCTTCCAGCTGAGCTGTGAGTACTGCACCATGAAGTTTGGCAACATTGCTGGACTTTTCCAGCACATGAGAGGCACTCACATGGACAGATTGAGCAGCCCGAACTCCTACTATGAACACTTCAATCGCCTGGCCACCGCTGGCACTTTCAGTCCGCGACTTGCTTTGGAtatgccaaaaattaaacCGGATTTGGGAAGTCCGGAGAGGGAAACGCGTCCAGCAGAGGATGATCTGCCCACGGATTTGAGCAGCAACAAAAGGCGGCCACTGACACCCAATCCCCAGACCCACACCCAACTGGCACCACCCACTGCCCCGCCTGGTGTCTTCTTCTGCAATCAATGCAACGCCGGATTGCCGGATTTCGAGAGCTTCAGGAATCATCTGAAGAGTCACATTGCCGAGGGAATGCAACTAGTTTGTCCACATTGCGGATTGAGTCTCCCGGAGCAATCCGAGTTCGAACGTCATGTGGTGGGTCACTTCCTCATTACCGGGTCAGAGTTCAACTGCAGTTCCACCTGCGGCAAGAGCTTTGCCAAGTCGGAGGATCTACAGCAACATCTGCTATCCGAGCATGTGCTAACCCTGCTGAAGTGCTCTTTGTGCTCGGAACTGTGTGAGAGCCGGATGGCCATGCAGCTTCATCTGGCCTGTGCCCATAGTCAGGAAACCAAACTCTTGCGGTGCAGCGCCTGTTTGGAACTCTTCCGGTCCGATGCCGAGTTCCATGTGCATGTAAAGACGCGTCATCAGCTGGGCGGACATCCCGCGTTGGGTGCCACTTCCAATGCTCCCACTAATCCGCTGCAGTGCATGTTCTGCCGAGCAGTTTGCTCTTCCGAACTGGAGATGCACTTCCATTTGGCCGCCCATGCCAGACAGTTTCGGTGCCCCTCCTGCCCGGAGACCTTCCATGTGGAGTTTCTTTTAGACCGTCACATGCAGAGTCAGCATGGTGGTGGTGTCAAGGACAAGGAGGCTAGCTCACCCAATATGGGCAGTCTCTATGTGAATGCCTTGCTACCTCCTttggcggcagcggcggcggctgcggctgccacaaacaacaacagtagcATTATCGACTACAATGTGGCATTCAAAGGCTTGTTTGGAGGAGCTGCTGCAGGAGCAGGACCAGCAGGAGGAGGTACAGGAGGTCCACCACCTTCGAGCAACAAATTCTACAGCCCCTTGCAAGTGGACACCAATGCATTGAAGCCCCAAACCTCCCCGCACCCGGCTCTGATGTACGGTCTGAGTCAGCGTTATCTGATGGAGATGTATGCCGCCAAGTCCACATCGCCTTCGGGCAATGAGGGAGTTGGAAACCCTCAACCTCCGACGCCACAGGCCACTGCAGTGCCACCGCCACCAAGTGCCACCACTGCCACCTTCAGTTGCGGAATGTGCGAACGACAGGATTTGCGCAGCGAGGCGGAACTCCACTCCCATCGAAAGTTGGCTCACAATCTGAAGACCGGAGTGAGTCTGAGATGTGCCTACTGTGCTGGCAACTTCAAGTCTCGGGCAGAACTGGAGCAGCATATGAAGAGCTGCCACAATTCGACGGGCAAACACAAGTGCTTGATATGCGATGAGGTGTTCCCCTCACCAGCCATCTTGGCCGAGCACAAGCTCCAGCACTCCAAGGTTGGACAGTCTGGCAAGTGCTCGCACTGTGGACAACCGCTGGAGGATGTGGCTGCCTTCAGGGCTCATCTATCAGAACATGGCAGTGATGGGGCATCCTTGCCATTAGCCTGCATTTGCTGCCGCCAGACGTTGCATTCGGAATTTGAGCTAAGTCTACATGCCAAATTCCACACGAAGTCCTCCTCGAGTGGTGGCAGTCTGCAGGAGCCAGTATGTGCCCTGTGCTTGGAGCCCTTGCCCGATGCCACTGAAGGACCAGCTAAGCTCTGCGACAAATGCTGCCGCAAACATAATCTGAATGGAAAGCGTGGCAAGCACACTGAGCCACCAGCATCTCTACAAGCTCCAACCGCGGCCTTCGTAGAGAACCGCTGCAACCTGTGCAAGATGATCCTGCCACATGCCCAGAAACTCCAGGAACACCTGGTGGAACATACCTTTGCCGGCACTGAACAGCGTGGCTTCAATTGCTATATCTGCTCGGCTGTTTTCACCGCACCTGGAGGATTACTCAACCACATGGGTGAGCATGGAGCTCATTCGAGGCCCTATGATTGCAGTATCTGCCCGGAGAAGTTCTACTTCCGAGCTGAGTTGGAACACCATCAAAGGAGTCACGAGCAGAGACCACGTCCACCTGTGCCAAAGGTAGAGGTTCCCACCATTCGGAACAGTTCACCCAGCCAGAGTCCAGTGAGAAGCCCCACGATTGTCAAGCAAGAGCTGTACGAAACGGATACAGTGGAGTCTGCTGGAGGTGAGGATGAGCCTGAGAATCATCCAGAGGAGGAGGAATACATCGAAGTAGAACAAATGCCGCACGAGACACGTCCAAGTGAGATTGGGTCGCAGTTGGAAAGGTCGACCAATAGCGCTTGA
Protein Sequence: MMALKMLYRGPSSRLENLIEKIQATKEISNNDMYSTHTSSSYSPSISDGTMTPNSHHLPGAPNTAGHEDHPAEGKVNGGTDGDELPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGAGSTGAGSKFDKLTGEGIKSRGDGSYQCQFCDKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRLDFPKRSRSSHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRGTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDMPKIKPDLGSPERETRPAEDDLPTDLSSNKRRPLTPNPQTHTQLAPPTAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLVCPHCGLSLPEQSEFERHVVGHFLITGSEFNCSSTCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPALGATSNAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGGVKDKEASSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGAAAGAGPAGGGTGGPPPSSNKFYSPLQVDTNALKPQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNPQPPTPQATAVPPPPSATTATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLPLACICCRQTLHSEFELSLHAKFHTKSSSSGGSLQEPVCALCLEPLPDATEGPAKLCDKCCRKHNLNGKRGKHTEPPASLQAPTAAFVENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHMGEHGAHSRPYDCSICPEKFYFRAELEHHQRSHEQRPRPPVPKVEVPTIRNSSPSQSPVRSPTIVKQELYETDTVESAGGEDEPENHPEEEEYIEVEQMPHETRPSEIGSQLERSTNSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00548267;
90% Identity: iTF_00504840;
80% Identity: -