Basic Information

Insect: Drosophila equinoxialis
Gene Symbol: MBD-R2
Assembly: GCA_018150345.1
Location: JAECWI010000005.1:7553701-7559614[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.9e-21 7.1e-18 64.1 0.1 3 76 441 512 439 513 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.9e-21	7.1e-18	64.1	0.1	3	76	441	512	439	513	0.93

Sequence Information

Coding Sequence: ATGGGCCGCCGGTGCTGTGTGGCCAACTGTCCGTCGACGTCGCGTTTGTTGGAACACCACGGCGTCACTTATCACTCGTTCCCGCAAGATCCCATCATCCGAGCCATTTGGATAAAGAACTCTCGTATTGGTCTAGACAAGCATATAACGAAGAGTGTTTTGGTCTGTTCGCGGCACTTTCGGCGCTTAGATTTTAATACGATTAGGAATGGAAAGTACTTGCTCAAGGCTCGTGTGTTTCCCACTGTCTTCCCCTGGGGTAAGATGGACCCGTCAGAAATCGAATCTGACCACCGGGCACTGCAGCAGGCGAACGTAGATGGGAGCACTGGCCCAACAGGAGCAAGCAGTTCGACAAGCGAGGACGTAATTAAAGATTCGGTGGAAACTATTGTGGCAAAAATAATGGCAGAGACGGCAGAGAGAAATGCTGCATTGGCTGCAACCGATGTCAAGTCTAATGAGGAGGGTGACAAAGATAAGGAGCTAAAGAGTCAACAGGACAGAAAAGAGAAACTTGAGGTCGAATCGCTCGGAACTTCTGCCGTCGATGCAACAACCATTTCCGACACTGGCTCTCCAGTGCCCACTCCCTCTTCGCCGCCAAAATACAGCAATCCCACAAATCTTACCATAGGAGCCCGCCTTGAGGCCCAATCAGTGGATGGCGCTTGGCTTCCTGCTCGCATCGTAGAGGTGAATGAGACGGAACAAACGCTCCTCGTGCGGTTCGATAAGAACAGCAAACTAAAGGGGACTCCTTCATCCAGTGGTAGTTTCCAAGAATGGTTAACCATCAAGTCGGATCGCCTTAGGCAACGCTTACAGCGTGTCCTCCCGCTGTTTGCTTTGGAAGAGAAATGCATGGCTCGTTGGTCGGGACCCAGGAAGTTTCCCGGCACCATTAAAAAGCTTCTCGGCAATGATACCTATGAGGTTCTCTTCGACGATGGCTACGTGAAGAATGTGCGAGCCGTTCATATGAACAAATTGCCACGACAATTGGGTGCAGTTGAAGTCACACCCACGATTTCCAGGATTCCAAGTCCTGTGTCGGCTACACCGCAGTTGCCGGTCAAAAGGTCCGCGAGTGGCAGTTCCAGTGCAGCTGCTTCTAGTGGAGTTGCTCCCTCAAGCAATAAAAAAATTAAATCAACACCACAACGAAAGGATTGGCCATTGCTCGACATGGCCAATTTGGATATTGCTTCTTTGTGTTTGCCAGAGATACCAAAGGATGGCGAATGGACTTGCCATTGGGTGAACGATCAACCGATTGGGTCTGAAGGTTTTCTTATTGTGGGCGAACATCAAAAACCCACGGTTATTGTACAGGATTGGCGCTTGCCTCCGGGCTGGGTGAAGCACATGTATCAGCGTTCCAATGTCCTTGGGAAATGGGATGTTATTCTAGTTTCGCCAAGTGGCAAACGTTTTCGCTCCAAATCGGATTTGAAGATATTCTTGGAATCCCAAGATTTGGTCTACAATCCCGATGTCTATGATTTTAGCATTCATCGTCGCCGCGCCAAAGATATCAATGCGTATGTGTATACCCATGATTACACTCCACAACAGCCCTTGAAGACGAAATCCACACCAATGGATGTCTCTCTTGACACATCGAGAAAGTCCAACGTTTCAGCCACTTTGCCGTCGACGCCAGCCACGCCCATAAGCTCGACAACAAGCAGTCAATATATGGAGACGCCAGTGGCAACATTGATGCCACCGGCTGAACTGATGTCACCCCAAGCCCAGACAAGCGAGGCGAAGGCACTGGCAGATAGCTCAGTGCCTGGGGATCTGGGAGAACTTGGCTCGGCCGCCGTGGAGAATGGCTTTGCATATATTGGTGGCTTGAAGGTCCAGATAATGGATAATCTATTTGTCTGCCCTCGTGAGGGTTGTGGCAAAACCTATCGCAAGGAGGACTTCCTTCAGATACATATACGTCATTACCACAAAGAGTTTGCCGAATATGTTAGCCATTGTCCCAAGATGCAGGAGCTGGCTGTGAAGCGTACTCATGCCTCATCGATTGATCAAGTGGATCAGATTGTACCCAAGAATCAAATACCAAATCAACAATTCTTTGCCAAAATGCATCAACAGGATATCCAACTTTCAAGATCATTGAAACGTCCATCCGGCGTACCACCGATTGCTGGTGCGGGGGAAGGTGTGGCAAGTGCAATCGGTACTACATCTCCTGCAGCAGGATCCGTGGGGACTAGCACTTTACCCATTAAATCGGTGGAAGAACCGTTAGATAAAAAGCCGCTTGTCGACTTGGTTGCAAGTCCAAATGCTGTCAGTACATTGATGCCACCATCGGAGGCAAACAGTTCACCACTTAACCGCTCCTCGGCCAAAAGGTCTCGCCTGTCACCTCCCAAGCGTACCTCAGGTTCTAGGAAGAGCATTCGTCAGCGTTCCATGCGTCCTTCTGTGGCCGAGCGGAATCCCGAGGAGACACCAGACGCAGCCAAAAAACGTCGTGTCGCCACGACTCCAATAAGTTCAATAGATTCGCCAGCTACAGCGGATTCTATATCGACTCCTTCATCAAATGATCACGACATTAATGCGGCTTTGCCCCCTCCATTGGAGCAGACCCCTCAATATATCAAAGAGAATGGCGAACTTATTCGCATTGTGCGCATGCGGCAAGAGGAGATTATCAATTGCATTTGTGAATATGGCGAGGAGGATGGTTTAATGATCCAATGTGAACTCTGCTTGTGCTGGCAGCACGGAGCCTGTAACGGCATCAACAAAGAGTTGGATGTCCCTGAGAAATATGTCTGTTACATTTGCCGTAATCCCCAGCGGAGACGTGATTCGATGCGATTCAAACATGACCAGGATTGGCTATACGAGGGCAAACTTCCAGTGGCCTCCTATCACACAGCCAATCCTCAGACGGCCAAGCAATTCGACTTGCTTAAACGGTCGCACACTCTAACCGGCAATCTCTTGGATGCCAAGCGTTCGATGCATTCATTAATGGTCAAAATTAATATTGCACGTAATCGTTGTCATCCCAAATTGTATCTGTGGGCCAAGAAATGGGATGAAGATAAATTGGGAGGCGAGGGCACCACACCAATCAAGCGCCCCAAACTGGAACAGCAGGAGCAAACGGAATTCCCAAATATACCACAACCGGAAGCTGCCATCGATCCTGAGGAGTGTCAATATCGTTTGATCGATCATGTCAAAGTGCAACAGCAATTGGTCATGAATCAATTGGAAAAGGAGGATACTCTGACGGACTTGAAAGATTGCGACATGGCCACTACCAAAGAAGCTGTGGCCGTATTTATTAAGGAACTGGAAACACTCAAGCGTCTGGCTAATCTCAATAAGGTAGCCAATATGAAGCAGGCTCTTAAAGATTCTGCCATAATTGCCAATACAGCAAATCCACCTCCAAACATATAA
Protein Sequence: MGRRCCVANCPSTSRLLEHHGVTYHSFPQDPIIRAIWIKNSRIGLDKHITKSVLVCSRHFRRLDFNTIRNGKYLLKARVFPTVFPWGKMDPSEIESDHRALQQANVDGSTGPTGASSSTSEDVIKDSVETIVAKIMAETAERNAALAATDVKSNEEGDKDKELKSQQDRKEKLEVESLGTSAVDATTISDTGSPVPTPSSPPKYSNPTNLTIGARLEAQSVDGAWLPARIVEVNETEQTLLVRFDKNSKLKGTPSSSGSFQEWLTIKSDRLRQRLQRVLPLFALEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYVKNVRAVHMNKLPRQLGAVEVTPTISRIPSPVSATPQLPVKRSASGSSSAAASSGVAPSSNKKIKSTPQRKDWPLLDMANLDIASLCLPEIPKDGEWTCHWVNDQPIGSEGFLIVGEHQKPTVIVQDWRLPPGWVKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKIFLESQDLVYNPDVYDFSIHRRRAKDINAYVYTHDYTPQQPLKTKSTPMDVSLDTSRKSNVSATLPSTPATPISSTTSSQYMETPVATLMPPAELMSPQAQTSEAKALADSSVPGDLGELGSAAVENGFAYIGGLKVQIMDNLFVCPREGCGKTYRKEDFLQIHIRHYHKEFAEYVSHCPKMQELAVKRTHASSIDQVDQIVPKNQIPNQQFFAKMHQQDIQLSRSLKRPSGVPPIAGAGEGVASAIGTTSPAAGSVGTSTLPIKSVEEPLDKKPLVDLVASPNAVSTLMPPSEANSSPLNRSSAKRSRLSPPKRTSGSRKSIRQRSMRPSVAERNPEETPDAAKKRRVATTPISSIDSPATADSISTPSSNDHDINAALPPPLEQTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGINKELDVPEKYVCYICRNPQRRRDSMRFKHDQDWLYEGKLPVASYHTANPQTAKQFDLLKRSHTLTGNLLDAKRSMHSLMVKINIARNRCHPKLYLWAKKWDEDKLGGEGTTPIKRPKLEQQEQTEFPNIPQPEAAIDPEECQYRLIDHVKVQQQLVMNQLEKEDTLTDLKDCDMATTKEAVAVFIKELETLKRLANLNKVANMKQALKDSAIIANTANPPPNI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00501041;
90% Identity: iTF_00618448;
80% Identity: iTF_00503304;