Basic Information

Insect: Drosophila emarginata
Gene Symbol: MBD-R2
Assembly: GCA_037075365.1
Location: JBAMCD010000221.1:5118548-5124094[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7.7e-22 2e-18 66.1 0.1 3 76 448 519 446 520 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7.7e-22	2e-18	66.1	0.1	3	76	448	519	446	520	0.93

Sequence Information

Coding Sequence: ATGGGCCGCCGTTGCTGTGTGGCCAACTGTCCGTCGACATCACGTCTAATGGAACACCACGGCGTCACTTACCATTCGTTCCCTCAAGACCCCGTCATCCGAGCCATTTGGATAAAGAATTCCCGGATAAGTTTGGATAAGCATATAACAAAAAGTGTTTTGGTATGTTCAAGGCACTTTCGTCGCTTGGACTTTAATACGATTCGAAATGGAAAGTATTTGCTTAAGTCTCGCGTGTTTCCCACTGTCTTTCCATGGGGCAAGATGGAGGCATCGGAAATCGAGGCAGATCATCGAGCGCTGCAGCAAGCCAATGTAGAAGGATCCAATGTGGCAACCGGATCAAATAGTTCCACCAATGAAGATGTAATAAAAGATTCAGTGGATTCGATTGTGGCCAAAATAATGGCTGAGACAGCAGAAAGAAATGCTGCATTAGCGGCTGCCGACGTCAAGGccaaagaagaggagaaagaggaagagcAGAAATGTGGCCAGGAGAGTAAAGAGAAGCCTGACGTAGAATTGCCTAGCACTACTGAAGACGCCTCACCAATTGCAGATGTGGGCTCTCCTCTGCCATCGTCTTCGTCACCACCAAAATACAGTAATCCCACAAATCTTACCATTGGAGCCCGACTCGAGGCGCAATCTGTTGATGGTAACTGGTTGCCAGCTCGCATCGTCGAAGTCAATGAGACGGAACAAACTTTACTGGTGCGCTTTGATAAAAACAGCAAACTGAAGGTTACTCCCTCATCCAGTGGCAGTTTTCAGGAATGGTTGACCATAAGATCGGATCGTTTAAGGCAACGTCTACAACGTGTTCTCCCGCTGTTTGCCCTTGAAGAGAAATGCATGGCCCGTTGGTCGGGTCCTCGGAAATTTCCCGGCACTATAAAGAAACTTCTTGGCAATGATACCTATGAAGTGCTATTCGATGATGGCTATGTAAAGAATGTCCGAGCGGTTCACATGAATAAATTACCACGTCAGTTGGGTGCCGTTGAAACCACACCCGCGGTCCCAGTTCCAAGTCCTGTTTTGGCTACTCAACATTTGCCCGTAAAAAGATCGAGTACTGCAGGAGCTGGAGCAGGAGTCAGTTCCAGTGCCAGTGCTGCTGGTAGTGGCGGCATTGCTGGTGGTTCGTCAAGCAgtaaaaaaagtaaatcaaCGCCACAGCGTAAGGATTGGCCTTTATTGGATATGGCCAATTTAGATATTgACTCTTTGTGCTTGCCGGTGATACCAAAGGATGGGGAATGGACATGCCATTGGGTGAACGATCAACCGATCGGTTCCGAAGGTTTTCTTATTGTGGGCGAACATCAGAAACCAACTGTTATTGTGCAGGATTGGCGTCTCCCACCTGGCTGGGTAAAGCATATGTATCAACGTTCCAATGTTCTAGGCAAATGGGATGTGATATTAGTTTCGCCCAGTGGCAAACGTTTTCGATCCAAATCggatttgaaaacatttttggaaTCTCAGGATTTGGTCTATAATCCCGATGTCTATGATTTTAGTATTCATCGTCGTCGGGCCAAGGATATAAATGCCTATGTCTATACCCATGATTATACTCCACAACAGCCattaaaaaccaaatcgaCACCTGTGGATGTCTCACTTGATTCCTCGAGAAAATCAACATTGTCGTCTATATCAGCGCCATCAACGCCTCTGAATACGACAAGAAGCAATCAATATATGGAGACACCTGTGGCTACATTAATGCCACCAGCAGAGCTCATGTCACCACAGGTTCAGTCCAGTGATGACAAGGGACTCGGAACACCAGCGGAAGGCTCAGCCACCTTGAGCCTAGGTGGCGATGTAGGTGAACTTCATACTGCCACAGTGGAAAATGGATTTGCTTATATCGGTGGCTTGAAAGTCCAGATAACGGATAATCTATTTGTCTGCCCTCGCGAGGGTTGTGGTAAAACCTATCGCAAGGAAGATTTCTTGCAGATTCATATACGTCATTATCACAAAGAGTTTGCCGAataTGTTAGTCACTGTCCCAAAATGCAGGAATTGGCCGTTAAACGTACCCATGCTTCTTCAATTGATCCAGTGGATTCGGTCGTTCCCAAGaatcaaatatcaaatcaACAATTCTTTGCCAAAATGCATCAACAGGATATTCAACTCTCTAGATCATTGAGACGTCCACCCGCATCAACAACTGTGGGTGAAGGTGTAGTTGGAGGTGTTGGGACATCGCCAACAGCAGGAAATCCAGGAATACCATCAAGTACTTCACCCATTAAACCAAGAGTTGAACAACCTGGCACTCCCATATCAATGGAGAATAAGTCGCAAGCAGAAACGACTTTAAGTCCAAGTACACCCATTCCCTCAACAACTACAATGGAAGCAAAAAGTTCACTTGGAAACTCGACGAGCCGTTCTGCAGCCAAGCGGTCTCGCCTTTCCCCCACAAAACGTTCTTCAGGCTCAAGAAAGAGTATTCGTCAGCGTTCTATGCGTCCATCGGTAACGGATCGTAATCCCGATGAGATGCAACAATCGAAACCAGATGCCTCCAAGAAACGTCGTGTGGCAACTACTCCTATTAGTTCTGTAGATTCACCAGCTACAACAGATTCAATATCGACACCCTCATCCAACGATCATGCTGATATAAATGCAGCTTTGCCACCACCACTGGAACAGACTCCTCAATATATTAAAGAGAATGGTGAACTTATACGCATTGTGAGAATGCGTCAGGAGGAAATTATCAATTGCATATGTGAATATGGTGAGGAGGATGGATTAATGATCCAATGTGAACTTTGCTTGTGCTGGCAGCATGGAGCCTGTAATGGCATTAACAAGGAGTTGGATGTCCCAGAGAAATATGTCTGTTATATTTGTCGTAATCCTCAACGCGGACGTGATTCGATGAGATTTAAACATGACCAAGATTGGCTTTATGAGGGTAAACTACCAGTGGCGTCCTATCACACATCCAATCCGCAAGTCACTAAGCAGTTTGACTTGCTTAAAAGATCACACACTTTAACCGGTAATCTGTTGGACGCCAAGCGATCGATGCATTCGTTGATGGTAAAGATTAACATAGCCCGTAATCGTTGCCATCCCAAATTGTATTTATGGGCAAAGAAATGGGATGAGGATAAATTGGGAGGTGAGGCCACCACACCAGTTAAGCGTCCAAAAATAGAGGAGCCGACAGATTTTCCCAATATACCACAGCCAGAGGCTGCCATTGATCCTGAGGAGTGTCAGGATCGTTTAATCGACCATGTTAAAGTTCAACAACAGTTGGTCATGAATCgtctaaatgaaattgaattggaaATGGATGaaTTGGAAAAAGAGGATACTTTACCGGACCTTAAAGATGCCGATATAGCTACAACCAAAGAAGCTGTGGCAACATTTATTAAAGAACTGGAGACTCTCAAGCGCTTGGCCAATCTCAATAAGGTGGCCAATATGAAGCAAGCTCTTAAAGATTCTATTACAGTTGacACAAAGTTGCTCAATGTAAATGAAACAGCTCGAATTCAATCGCCGTCTTTTGTGGTGTCCATACAGGAGTATAAATATGGTTATTACACACATCTTTGTGGTGGAACCATAATTGATGAACAATTTGTCATTACAGCCGCTCATTGTGTTTTAAAGCCAAAACCTATATATAAGAGTAACCTCTTTGTTATGGGTGGATCTACCAGACTATTTAGTAAAACTTCAACCCGTTTTCGGGTCATTGGTATGAGTactcataaaaaatttaaattcctCAAAGGCTATGATATTCTTCTCTTGAGAGTTTATCCCAAATTTTCCTTAGACGGAAAACGATTTCGCAAACTTAATGTTAAGGAATCGAAAAGACGTATCACTGGGCTAAATGCTGTTTTATTGGGTTGGGGGCGTTTGGGTCTAAGGCCAAACAATCCTAAAAATTTGGAATCCATATTCTTTCAAACTATTGATAATAGGGTTTGCCtaaaaaaatatcgatttaaatATCTTACCCACACGGAAATTTGCGCAGTCCATTCTGATGAAGGACCACGTGGAGCCTGTGATGGTGATTCGGGTGGCCCTTTGGTGGATGTGAAGCAAACTGAATTATATGGATTACTTTCCTATGGCCGCAAAGCTTGTCAAACACATAAGCCTTACGCCTTTACCAGGATAAGTACACACGTTAATTGGATCAAACAGGAAATGAGCAAATTAAGGAAAATTGTTTCAGGATAA
Protein Sequence: MGRRCCVANCPSTSRLMEHHGVTYHSFPQDPVIRAIWIKNSRISLDKHITKSVLVCSRHFRRLDFNTIRNGKYLLKSRVFPTVFPWGKMEASEIEADHRALQQANVEGSNVATGSNSSTNEDVIKDSVDSIVAKIMAETAERNAALAAADVKAKEEEKEEEQKCGQESKEKPDVELPSTTEDASPIADVGSPLPSSSSPPKYSNPTNLTIGARLEAQSVDGNWLPARIVEVNETEQTLLVRFDKNSKLKVTPSSSGSFQEWLTIRSDRLRQRLQRVLPLFALEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYVKNVRAVHMNKLPRQLGAVETTPAVPVPSPVLATQHLPVKRSSTAGAGAGVSSSASAAGSGGIAGGSSSSKKSKSTPQRKDWPLLDMANLDIDSLCLPVIPKDGEWTCHWVNDQPIGSEGFLIVGEHQKPTVIVQDWRLPPGWVKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKTFLESQDLVYNPDVYDFSIHRRRAKDINAYVYTHDYTPQQPLKTKSTPVDVSLDSSRKSTLSSISAPSTPLNTTRSNQYMETPVATLMPPAELMSPQVQSSDDKGLGTPAEGSATLSLGGDVGELHTATVENGFAYIGGLKVQITDNLFVCPREGCGKTYRKEDFLQIHIRHYHKEFAEYVSHCPKMQELAVKRTHASSIDPVDSVVPKNQISNQQFFAKMHQQDIQLSRSLRRPPASTTVGEGVVGGVGTSPTAGNPGIPSSTSPIKPRVEQPGTPISMENKSQAETTLSPSTPIPSTTTMEAKSSLGNSTSRSAAKRSRLSPTKRSSGSRKSIRQRSMRPSVTDRNPDEMQQSKPDASKKRRVATTPISSVDSPATTDSISTPSSNDHADINAALPPPLEQTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGINKELDVPEKYVCYICRNPQRGRDSMRFKHDQDWLYEGKLPVASYHTSNPQVTKQFDLLKRSHTLTGNLLDAKRSMHSLMVKINIARNRCHPKLYLWAKKWDEDKLGGEATTPVKRPKIEEPTDFPNIPQPEAAIDPEECQDRLIDHVKVQQQLVMNRLNEIELEMDELEKEDTLPDLKDADIATTKEAVATFIKELETLKRLANLNKVANMKQALKDSITVDTKLLNVNETARIQSPSFVVSIQEYKYGYYTHLCGGTIIDEQFVITAAHCVLKPKPIYKSNLFVMGGSTRLFSKTSTRFRVIGMSTHKKFKFLKGYDILLLRVYPKFSLDGKRFRKLNVKESKRRITGLNAVLLGWGRLGLRPNNPKNLESIFFQTIDNRVCLKKYRFKYLTHTEICAVHSDEGPRGACDGDSGGPLVDVKQTELYGLLSYGRKACQTHKPYAFTRISTHVNWIKQEMSKLRKIVSG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00501083; iTF_00555885; iTF_00555844; iTF_00483729; iTF_00483685; iTF_00600313; iTF_00600354; iTF_00577819; iTF_00577776; iTF_00591005; iTF_00590964; iTF_00604133; iTF_00555081; iTF_00555124; iTF_00604089; iTF_00612070; iTF_00523693; iTF_00612110; iTF_00523733; iTF_00503304; iTF_00503266; iTF_00618448; iTF_00618408; iTF_00571195; iTF_00571153;
90% Identity: iTF_00555885;
80% Identity: iTF_00501083;