Basic Information

Insect: Drosophila demipolita
Gene Symbol: -
Assembly: GCA_035042405.1
Location: JAWNLI010000047.1:937403-941441[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.8e-14 5.4e-11 41.9 0.0 8 73 306 367 300 370 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.8e-14	5.4e-11	41.9	0.0	8	73	306	367	300	370	0.88

Sequence Information

Coding Sequence: ATGAATTCGAAATCACCAGAGACTAGAGAAAGATCCAGCCGCTCAAAATCGCCCGCAAGGAGTTTTTTTGAGGATTCAAGCTCAATCAGCGATTGTTATTCTTCAGACTCGAATGACAGTCGCAAAAAGCTGAAGATCGAAAAGAGTCAATCGGAGGTTGATGCTCTAGTGGGTTGGAGCGACCATTTTCCTTTCTCGACCATCCATAACCTGGAGAGCAACTTAGACATGGAACACcagctgcccacTGACCTGATGGACATTGCTGCCAATGGGCTAAGAATTTATCCCAGAGAGCAAGAGGAAGAGGAACAATCGCAGTTGCATCCAGCACCACAGACGCCGCTGGCGTCAACGTCTATGTCTGATTCTGATGCCTTCTCATCCGTTTCAACAATGAATTCTCCCctaacaacagcatcagcagtagcatcagccacaacagcatcagcagtagCATCAGCCGCAACAGCCCCAACAAATACATCAGATAGtagcacacacaccacaatATCGACTGCTGCATTATTTCAGACTACTACGCAGACAGACAACATCACCTGCGGTATCACCGATATCACCAATAACGACAGCGGTTTAAACTCAATGCCAACTGCAACATCTTCTCCTCCACAACCATCAGCAGAGTTAAACACAGAAGCAGAACCACCAACAGATATAGACAAACAGGTGAACAACCGCACTCGCTCCTATAGTGCGTCGTACAGCGATGAGGTCGGCGAAACGACAAAGCGTCCCAAGGAACCAACTGATGACAAGGATCAGCCACTTTGCACGCTACAGATGCGCTCCAAATCGATGTATCAATTAGACCCCCCTACCACTAATGCAAAGACGCCTAAACGACGACGCTCGGTTGCTGCGAACAAATTGCTAGTCACAGATCCCTTTTATCGCTTGCCCTTCGACTACGGCTGGAAACGTGAATTGGTGTTGCGCAGCAATTTGAACAATGCACGCCAACAGGCCGACGTTATATTCATATCGCCAGCGGGCAAGAAGCTGCGCTCGAGAGATGACATTATCCCACTGCTTGTGCCCAATCTGACAATTGATCATTTTTGCTTTAAGCCCCAGCTTCAGAATGCTGGCGAGAAATACGAAACGGTTCGCCAGGGTCAGTCTGTTAAGGAACGTCGCAAATTGATAGCCGCCAcaaagcagcagaaacagcaagaacaagtgcaacagcatcagcagcagcagaagaagagtgagccgcagcagcagcagaagcaaaaggagcagaagaagcaacaagagcagcagcagcagccacaacaacagcagcagttggctaACAGTATCGATCCCGGTCAACAAGCATCATCCACGCTAACACCCGTATGCGGGAAACGTGTGCCTAAGCCTAAGGTGCCCAAGGGTGCTAGTCCGCCGCCCGAGGGTTGGACACCAACGATGGCGGTCAAGGGAAATGCTCGCGTCCTGGCTGCGAGCAATGGTAACAGCAGTGGCGGCATCGGcgccagcggcagcaacagcgcaCGCAAACGGGGCAACCAGACGATCAAATCTACAAAGGCAGCACCAGAGCCGACGTCGGTTGTGCCGTCCCTTTTGCCGCCAGCAGATATAGcacgacagcagcaggcacGTGGACTTGGACTGACCAATGTCAATGCTAGTGCCAGTGCCAATGTCAATGGCAATGGGATCAATAAGCCGGATAAGAAAGTAATCGATGAGAACGTGGACGCCGCCGGCGATGGGGTCATCGTCAAAGAGATTGAGCTTCCGGGCGCTCTTCCCCCTGCTAAACTGCTCAGAGATGATTCTCCTGCAGGTCGTGGCGGTAGAAAAATAACACCTAGGCCAATGGAGGTGGTTGTCATTAACGGTCGCAAGGCAATCGCCATTGCTGGCCCACCGCGGCGTACGCGTCCCGAACTACCACTCTATATTGGCGATCCAGAGTTGGGCATCAGTACGAGACTTTTCACTAGGCGCCACGCCGCAGCTAAGCGCCAGCAAGTCGTTGATTGTATTTCTGATGGCATCATGGGCTGCCAGCTGATGACGGCCATTATGAAGACGCTTGACATGCACGATCGCGTACGCTTGTCAAGAGTGTGCCAGACCTGGGCTATGATAGGCCGCGAAAGGAGCGTTTGGCGTACGGTGAAGTTGCGCGATACGCACATCACCAACTTTAAACTTCTGCTGCGTGCTATGGCGATTTATGGCACCGTCGAGCTCGATATGATGGGCGTGAGAATCGACAATCCGAAGATGCGCTTGGACGGTGATTTGCGAGTATTGCATAATTTGCGCATTATCCGCACCGATTCGAGCGAGGCGGAGTTCATCGAGACAATTATAAAGCGCCTTCCAAGACTTCAGGAGCTGCGTACAACGTGCACCAGTCGCACTCTGAATGTGGCCAACATCGGAAAAGTGctgaatttgtgtgtgctgcgcATTCGCATGCTGGAGCCAAAGGCTAGCATCATTTCATTGCCGCCGATGCAGAATCTGAGCTGCTTGCGAGAGCTGAGCTTGCGCGGCATTAGTAACATGGCTCATCTGGAGCTGTTGCAGCTGGAGGGATTGCAGCAGCTGGAGACGCTCGTGCTGGGCTCGTGTCGCGGCATGAAGGTGGCAACGTTCGGGCAGCAGGTGCTTCCCAGTCTGAAACGTTTGCGCCACTTGCGCCTGGAGAACCACAGCAATAGCTCATTTAACATACATGAAATCATGGCTGGCATTGCCGCTGCTGGCAGTGTGAAGCGTGTCGAACTCATAAATGTCAAGGTCGATGCGGAGTTGAGTCGTCAGTTGTCCGAGTGTAAATCTTTGCAGGAGCTGCTACTGTTGCCAAACTTCCACAATCATACCGCCTATATGATGCACTACATAATGCAGGCCGTCAACGAGAACAGCGAACAGCTCAAGGTGTTTTGCTTGGGGATCACCTACGAACTGCTTAGAGTGACTCGAGCATTGGCCATGATCCCCGAAAAGGACTGTGTCCCAGTGCTGCTGCCCATTCCAGGCGTACCCGAAAATGATGTACTAAATAAGTCCGATGAGCCAATCGCCTATTTGCCGGTAGATCGCCTAGAATCGATTTTACACCATACGATGCCGCAGGCTTGGCTAACAGTCGCCAAGGTTTCACAGCTCGAGacaataaatctaaaataccAGGCGGCTCCATCCACCGACAAAGGCGGgttttcaaacatttaa
Protein Sequence: MNSKSPETRERSSRSKSPARSFFEDSSSISDCYSSDSNDSRKKLKIEKSQSEVDALVGWSDHFPFSTIHNLESNLDMEHQLPTDLMDIAANGLRIYPREQEEEEQSQLHPAPQTPLASTSMSDSDAFSSVSTMNSPLTTASAVASATTASAVASAATAPTNTSDSSTHTTISTAALFQTTTQTDNITCGITDITNNDSGLNSMPTATSSPPQPSAELNTEAEPPTDIDKQVNNRTRSYSASYSDEVGETTKRPKEPTDDKDQPLCTLQMRSKSMYQLDPPTTNAKTPKRRRSVAANKLLVTDPFYRLPFDYGWKRELVLRSNLNNARQQADVIFISPAGKKLRSRDDIIPLLVPNLTIDHFCFKPQLQNAGEKYETVRQGQSVKERRKLIAATKQQKQQEQVQQHQQQQKKSEPQQQQKQKEQKKQQEQQQQPQQQQQLANSIDPGQQASSTLTPVCGKRVPKPKVPKGASPPPEGWTPTMAVKGNARVLAASNGNSSGGIGASGSNSARKRGNQTIKSTKAAPEPTSVVPSLLPPADIARQQQARGLGLTNVNASASANVNGNGINKPDKKVIDENVDAAGDGVIVKEIELPGALPPAKLLRDDSPAGRGGRKITPRPMEVVVINGRKAIAIAGPPRRTRPELPLYIGDPELGISTRLFTRRHAAAKRQQVVDCISDGIMGCQLMTAIMKTLDMHDRVRLSRVCQTWAMIGRERSVWRTVKLRDTHITNFKLLLRAMAIYGTVELDMMGVRIDNPKMRLDGDLRVLHNLRIIRTDSSEAEFIETIIKRLPRLQELRTTCTSRTLNVANIGKVLNLCVLRIRMLEPKASIISLPPMQNLSCLRELSLRGISNMAHLELLQLEGLQQLETLVLGSCRGMKVATFGQQVLPSLKRLRHLRLENHSNSSFNIHEIMAGIAAAGSVKRVELINVKVDAELSRQLSECKSLQELLLLPNFHNHTAYMMHYIMQAVNENSEQLKVFCLGITYELLRVTRALAMIPEKDCVPVLLPIPGVPENDVLNKSDEPIAYLPVDRLESILHHTMPQAWLTVAKVSQLETINLKYQAAPSTDKGGFSNI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00535307; iTF_00511271; iTF_00543742; iTF_00500303; iTF_00543740; iTF_00543741;
90% Identity: -
80% Identity: -