Dcon014013.3


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila conformis
Gene Symbol
ewg
Assembly
GCA_035041375.1
Location
JAWNLE010001151.1:3856884-3861013[-]

Transcription Factor Domain

TF Family
Nrf1
Domain
Nrf1_DNA-bind domain
PFAM
PF10491
TF Group
Basic Domians group
Description
In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 5.4e-108 2.5e-104 347.6 0.0 1 212 46 256 46 257 0.98
2 4 1 4.8e+03 -3.0 4.4 91 111 377 397 351 433 0.49
3 4 2.2 9.9e+03 -4.0 0.5 13 15 459 461 450 495 0.53
4 4 0.052 2.4e+02 1.3 3.9 2 33 768 799 767 802 0.84

Sequence Information

Coding Sequence
ATGCTCGACGATGATATGCAGAGTCTGGGCACCGATGACGAGGACGATGATTTGATTAGTAGCGAGGGCAGCTTGTACGATGGTGATCTTGCCACAATTGTTAACGATGATGTTGCCCATCAGTTGGCTGCCGCTGGCCCAGTGGGCGTGGCGGCAGCGGCTGCCATTGCCAGCTCAAAGAAACGCAAGCGTCCGCATTGCTTCGAAACGAATCCATCGGTCCGCAAGCGTCAACAGAATCGTCTGTTGCGCAAATTGCGTGGCATCATCTACGAGTTCACCGGCCGTGTTGGCAAACAGGctgtggtgctggtggcgaCGCCGGGCAAACCGAATACCAGCTACAAGGTGTTTGGGGCCAAGCCGCTGGAGGATGTGCTACGCAATCTGAAGAACATTGTGATGGATGAGCTGGACAATGCGCTGGCGCAACaggcgccgccgccgccacaggAGGACCCGTCGCTGTTCGAGCTGCCCGGCCTGGTCATCGATGGCATACCGACGCCCGTCGAGAAGATGACGCAGGCCCAGCTGCGCGCCTTCATACCGCTCATGCTGAAATATTCGACGGGACGGGGCAAGCCCGGCTGGGGCAGGGAGTCGACGCGTCCGCCTTGGTGGCCCAAAGAGTTGCCCTGGGCAAACGTGCGCATGGATGCCCGCTCCGAGGATGACAAGCAGAAGATCAGCTGGACGCATGCGCTGCGCAAGATCGTGATCAATTGCTACAAATATCATGGACGCGAGGATCTGTTGCCGACATTCGCTGACGATGAGGACAAGGTGAATGCGCTGATCTCGCAGTCGGGCGATGAGGACGAGGACATGGAGCAGCTATCGAATACGCCCACCATACAAACGGTGCAAACGGTGACACCGGCAGTAACCACAACCACCAGCCAAccacAGCAGGTGAACGTGGTGAAGATTAACAGTGCCGGTACCGTGATCACAACGCACACGGCTCAATCGAATACGCCGGCGCCAACGATTATCCAGAGCACAAACAATCAGCATGTGACAACGACGGCCACGCTGCCGGCATCCACAAAGATTGAGATATGCCAGGCACCggcgccacagcagcaacaccagcagcagcatcagcagcagcaccatcaccaccaccaacagcagcagcagcagcaacagcagcaccaccaccaccagcaacagcagcagcagcatcatcatcaacaccATCATCACACAACCAGTGGCAATAATACGGTGCACATTCAAGCGATTGGCCAAGCACAGCCGCAGACCATACAGCTGACAACGGCGAGCGGTACGGCAACGGCCACCGCTGTGCCAACGACAGCGGCAGCTGTAAGtgcatcatcagcagctgcagccgccgcGGCTGCTGCCGCCCAACAAGCGGCACAGCAATCGAATGCTGCACAAACCGTAACCGCCCAACAGATCGCCAACGCCCAAGTTTGCATCGAGCCCATAACGCTGAGCGACGTTGATTACACCACACAAACAGTGTTGTCGCAGAATGCCGATGGTACCGTGTCTCTCATCCAGGTGGATCCCAACAATCCGATCATAACGCTGCCCGATGGCACAACGGCCCAGGTGCAGGGTGTGGCAACGCTGCATCAGGGCGAGGGTGGCGCCACCATACAAACGGTACAAAGCTTAACCGATGTGAATGGTCATGAGAACATGACCGTGGATCTAACCGAGGCGCAGGATGGTCAAATCTTTATCACCACCGAAGATGGCCAAGGCTATCCGGTGTCCGTGAGCAATGTCATATCGGTGCCCGTCTCCATGTACCAGTCGGTGATGGCCaacatgcagcagctgcagacgAATAGCGATGGCACCGTCTGCTTGGCCCCCATGCAGGTAGATAACAGCAATAGCCCCAACTCCTCCAATAGTGCTACGcgcaccaccaccgccaccaacaacaacaataataataataataatagtagcaGCGGCACAACTGCTGCGCCAACTTCGCTGCTTGGCATCTCGGTGATCAACACTGGCTGCGCTGCTGTGCTGGGCCGACGCAGTGCAGCTGGCttagccacagcaacagctgctgctgcagcgccgAATGCCGGACAACAGCCGGCGGCGCTCACATTGCAAGCGCCGCCAGGCACGCGCTTATATTGGGCAGCGACGGGTCCGGCATGCGGTGGCAGcgccagcggcaacagcagcaatttaaatgctgGCTTTAAtcttgccaacaacaataataacagcatgcttaataacaacaacaacaatacaattaaaatgccgCTGCCCATTGTTTTGACAGcgccagcagccgcagcagcagcagcagcgtcatcGACGTCGCAGCGACGCCATGAAGCGCACGCATCGCGTCGCTCAATAACAGCGCAAAAGCGACGCAAGCCGATACACGGCGCTAACAGCAgtaccagcaacaacagcaagctaAATGTTAGCAAAGGTGTTCGAaatgctaatgctgctgctgccgctgctgcgcgGGCGGCGGCTGCACcgagcagcgctgctgctgcggaaaTACGCTGCGTGAACAGCGCCAGACTGACAAATTTGGGCAGTGCGCAGCTGCAGATGCCCGCTAAAACCATTAAATTAGAGCATTTGGAGTAG
Protein Sequence
MLDDDMQSLGTDDEDDDLISSEGSLYDGDLATIVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVTPAVTTTTSQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAPQQQHQQQHQQQHHHHHQQQQQQQQQHHHHQQQQQQHHHQHHHHTTSGNNTVHIQAIGQAQPQTIQLTTASGTATATAVPTTAAAVSASSAAAAAAAAAAQQAAQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLQTNSDGTVCLAPMQVDNSNSPNSSNSATRTTTATNNNNNNNNNSSSGTTAAPTSLLGISVINTGCAAVLGRRSAAGLATATAAAAAPNAGQQPAALTLQAPPGTRLYWAATGPACGGSASGNSSNLNAGFNLANNNNNSMLNNNNNNTIKMPLPIVLTAPAAAAAAAASSTSQRRHEAHASRRSITAQKRRKPIHGANSSTSNNSKLNVSKGVRNANAAAAAAARAAAAPSSAAAAEIRCVNSARLTNLGSAQLQMPAKTIKLEHLE