Dtri001653.3
Basic Information
- Insect
- Drosophila trichaetosa
- Gene Symbol
- ewg
- Assembly
- GCA_035043205.1
- Location
- JAWNNE010000071.1:708021-712134[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 5.5e-108 2.4e-104 347.6 0.0 1 212 46 256 46 257 0.98 2 4 2 8.8e+03 -3.9 4.8 91 104 378 391 351 429 0.55 3 4 2 8.8e+03 -3.9 0.5 12 15 460 463 451 497 0.55 4 4 0.14 6.2e+02 -0.1 3.6 5 33 773 801 770 803 0.83
Sequence Information
- Coding Sequence
- ATGCTCGACGATGATATGCAGAGTCTGGGCACCGATGACGAGGACGATGATTTGATTAGTAGCGAGGGCAGCTTGTACGATGGTGATCTTGCCACAATTgttaatgatgatgttgccCATCAGTTGGCTGCCGCTGGCCCAGTGGGcgtggcggcagcagctgccattgCCAGCTCAAAGAAACGCAAGCGTCCGCATTGCTTCGAAACGAATCCATCGGTCCGCAAGCGTCAACAGAATCGTCTGTTGCGCAAATTGCGTGGCATCATCTACGAGTTCACCGGCCGTGTTGGCAAACAGGctgtggtgctggtggcgACGCCGGGCAAACCGAATACCAGCTACAAGGTGTTTGGGGCCAAGCCGCTGGAGGATGTGCTGCGCAATCTGAAGAACATTGTGATGGATGAGCTGGACAATGCGCTGGCGCAACaggcgccgccgccgccacaggAGGACCCGTCGCTGTTCGAGCTGCCCGGCCTGGTCATCGATGGCATACCGACGCCCGTCGAGAAGATGACGCAGGCCCAGCTGCGCGCCTTCATACCGCTCATGCTGAAATATTCGACGGGACGGGGCAAGCCCGGCTGGGGCAGAGAGTCGACGCGTCCGCCTTGGTGGCCCAAAGAGTTGCCCTGGGCAAACGTGCGCATGGATGCCCGCTCCGAGGATGACAAGCAGAAGATCAGCTGGACGCATGCGCTGCGCAAGATCGTGATCAATTGCTACAAATATCATGGACGTGAGGATCTGTTGCCGACATTCGCTGACGATGAGGACAAGGTGAATGCGCTGATCTCGCAGTCGGGCGATGAGGACGAGGACATGGAGCAGCTATCGAATACGCCCACCATACAAACGGTGCAAACGGTGACACCGGCAGTAACCACAACCACCAGCCAAcctcAGCAGGTGAACGTGGTGAAGATTAACAGTGCCGGCACCGTGATCACAACGCACACGGCTCAATCGAATACGCCGGCGCCAACGATTATCCAGAGCACAAACAATCAGCATGTGACAACGACGGCCACGCTGCCGGCATCCACAAAGATTGAGATATGCCAGGCACCggcgccacagcagcaacaccagcagcagcatcaacagcagcagcagcaccatcaccaccaccaacagcagcagcagcagcaacagcagcaccaccaccaccagcaacagcagcagcagcatcatcatcaacatcatcatcacacAACCAGTGGCAATAATACGGTGCACATTCAAGCGATAGGCCAATCACAGCCGCAGACCATACAGCTGACAACGGCGAGCGGCACGGCAACGGCCACCGCAGTGCCAACGACAGCGGCAGCTGTAAgtgcatcatcagcagcagcagccgccgcggCTGCTGCCGCCCAACAAGCGGCACAGCAATCGAATGCTGCCCAAACCGTAACCGCCCAACAGATCGCCAACGCCCAAGTTTGCATCGAGCCCATAACGCTGAGCGACGTTGATTACACCACACAAACGGTGTTGTCGCAGAATGCCGATGGTACCGTGTCTCTCATCCAGGTGGATCCCAACAATCCGATCATAACGCTGCCCGATGGCACAACGGCTCAGGTGCAGGGTGTGGCAACGctgcatcagGGCGAGGGTGGCGCCACCATACAAACGGTACAAAGCTTAACCGATGTGAATGGTCATGAGAACATGACCGTGGATCTAACCGAGGCGCAGGATGGTCAAATCTTTATCACCACCGAAGATGGCCAAGGCTATCCGGTGTCCGTGAGCAATGTCATATCGGTGCCCGTCTCCATGTACCAGTCGGTGATGGCCaacatgcagcagctgcagacgAATAGCGATGGCACCGTCTGCTTGGCCCCCATGCAGGTAGATAACGGCAATAGCCCCAACTCCTCCAATAGTGCTACgcgcaccaccaccaccaccaccaccaacaacaacaataataatactaataatagtAGCAGCGGCACAGCTGCTGCGCCAACTTCGCTGCTTGGCATCTCGGTGATCAACACTGGCTGCGCTGCTGTGCTGGGCCGACGCAGTACAGCTGGCttagccacagcaacagctgctacTGCAGCGCCAAATGCCGGACAACAGCCGGCGGCGCTCACATTGCAAGCGCCGCCAGGCACGCGCTTATATTGGGCAGCGACGGGTCCGGCATGCGGTGGCAGcgccagcggcaacagcagcaatttaaatgctgGCTTTAAtcttgccaacaacaataataacagcatgcttaataacaacaacaacaatacaattaaaatgccgCTGCCCATTGTTTTGACAGcgccagcagccgcagcagcagcgtcatcGACGTCGCAGCGACGCCATGAAGCGCACGCATCGCGTCGCTCAATAACAGCGCAAAAGCGACGCAAGCCGATACACGGcgctaacagcagcagcagcagcagcaacaacagcaagctaAATGTTAGCAAAGGTGTTCGAAatgctaatgctgctgctgccgctgctgcgcgGGCGGCGGCTGCACcgagcagcgctgctgctgcggaaaTACGCTGCGTGAACAGCGCCAGACTGACAAATTTGGGCAGTGCGCAGCTGCAGATGCCCGCTAAAACCATTAAATTAGAGCATTTGGAGTAG
- Protein Sequence
- MLDDDMQSLGTDDEDDDLISSEGSLYDGDLATIVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVTPAVTTTTSQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAPQQQHQQQHQQQQQHHHHHQQQQQQQQQHHHHQQQQQQHHHQHHHHTTSGNNTVHIQAIGQSQPQTIQLTTASGTATATAVPTTAAAVSASSAAAAAAAAAAQQAAQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLQTNSDGTVCLAPMQVDNGNSPNSSNSATRTTTTTTTNNNNNNTNNSSSGTAAAPTSLLGISVINTGCAAVLGRRSTAGLATATAATAAPNAGQQPAALTLQAPPGTRLYWAATGPACGGSASGNSSNLNAGFNLANNNNNSMLNNNNNNTIKMPLPIVLTAPAAAAAASSTSQRRHEAHASRRSITAQKRRKPIHGANSSSSSSNNSKLNVSKGVRNANAAAAAAARAAAAPSSAAAAEIRCVNSARLTNLGSAQLQMPAKTIKLEHLE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00496330;
- 90% Identity
- iTF_00592831;
- 80% Identity
- -