Basic Information

Insect: Drosophila engyochracea
Gene Symbol: ewg
Assembly: GCA_035042385.1
Location: JAWNLK010000167.1:10600877-10605483[+]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5.8e-108 2.4e-104 347.6 0.0 1 212 46 256 46 257 0.98

2 3 1.5 6e+03 -3.4 5.5 91 109 381 399 351 436 0.53

3 3 0.8 3.3e+03 -2.6 1.1 5 23 797 817 791 830 0.49

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5.8e-108	2.4e-104	347.6	0.0	1	212	46	256	46	257	0.98
2	3	1.5	6e+03	-3.4	5.5	91	109	381	399	351	436	0.53
3	3	0.8	3.3e+03	-2.6	1.1	5	23	797	817	791	830	0.49

Sequence Information

Coding Sequence: ATGCTCGACGATGATATGCAGAGTCTGGGCACCGATGACGAGGACGATGATTTCATTAGTAGCGAGGGCAGTCTGTACGATGGTGATCTTGCCACCACAGCTAACGATGAAATTGGCCATCAGCTGGCTGCCGCTGGgccagtgggcgtggcagctgcagctgccattgCCAGCTCAAAGAAACGCAAGCGTCCGCATTGTTTCGAAACGAATCCATCGGTCCGCAAACGTCAACAGAATCGTCTGCTGCGCAAATTGCGTGGCATCATCTACGAGTTCACCGGCCGTGTTGGCAAACAGGctgtggtgctggtggcgaCGCCGGGCAAACCGAATACCAGCTATAAGGTGTTTGGCGCTAAGCCGCTGGAGGATGTGCTGCGCAATCTGAAGAACATTGTGATGGATGAGCTGGACAATGCGCTGGCGCAACAGGCGCCGCCGCCGCCCCAGGAGGATCCATCGCTGTTCGAGCTGCCCGGCCTGGTGATCGATGGCATACCGACGCCCGTCGAGAAGATGACACAGGCCCAGCTGCGCGCCTTCATACCGCTCATGCTGAAGTATTCGACGGGTCGGGGCAAGCCCGGCTGGGGCAGGGAGTCGACACGTCCGCCGTGGTGGCCCAAAGAGTTGCCGTGGGCAAATGTGCGCATGGATGCCCGCTCCGAGGATGACAAGCAGAAGatCAGCTGGACGCATGCGCTGCGCAAGATCGTGATCAATTGCTACAAATATCATGGACGCGAGGATCTGTTGCCCACATTCGCTGACGATGAGGACAAGGTGAATGCGCTGATCTCACAGTCGGGAGACGAGGATGAGGACATGGAGCAGCTATCGAATACGCCCACCATACAAACGGTGCAAACCGTCGCACCGGCAGTAACCACAACCACCAGCCAAccacagcaggtGAACGTGGTGAAGATTAACAGTGCCGGCACGGTGATCACAACGCACACGGCTCAATCGAATACGCCGGCGCCAACGATTATCCAGAGCACAAACAATCAGCATGTGACAACAACGGCCACGCTGCCAGCATCCACTAAGATTGAGATATGCCAGGCACCggcgccacaacaacaacaccagcagcagcagcatcaacagcagcagcagcaccatcaccaccaccaacaacagcagcaacagcagcagcagcagcaacaccaccaacatcagcagcaacagcagcagcatcaccatcatcatcatcatacaACAAGTGGCAATAATACGGTGCACATTCAAGCGATAGGCCAAGCACAGCCGCAGACCATACAGCTGACAACGGCGAGCGGCACGGCAACGGCAACCGCAGtgccaacaacagcggcagctgtaagtgcatcatcagcagcggcggcggcggcggcggccgCTCAACAAGCGGCACAGCAATCAAATGCTGCACAAACCGTCACCGCCCAACAGATCGCCAATGCCCAAGTTTGCATCGAGCCCATAACGCTGAGCGACGTTGATTACACGACACAAACGGTGTTGTCGCAGAATGCCGATGGTACCGTCTCTCTCATCCAGGTGGATCCCAACAATCCGATCATAACGCTGCCCGATGGCACAACGGCCCAGGTGCAGGGTGTGGCAACGctgcatcaGGGCGAGGGTGGCGCCACCATACAAACGGTACAAAGCTTAACCGATGTGAATGGTCATGAGAACATGACCGTGGATCTAACCGAGGCGCAGGATGGTCAAATCTTTATCACCACCGAAGATGGACAAGgcTATCCGGTGTCCGTGAGCAATGTCATATCGGTGCCCGTCTCCATGTACCAGTCGGTGATGGCCAACATACAGCAGCTGCAGACGAACAGCGATGGCACCGTCTGCTTGGCCCCCATGCAGGTAGATAACAGCAATAGCCCCAACTCCTCCAATAGTGCCACGcgcaacaccaccaacaacagcaataacaacattagcaacaacaacaacaacaacaacaccaacaacaataataataatagtagtagtagcgGCTCAGCTGCTGCGCCAACTTCGCTGCTTGGCATCTCGGTGATCAACACTGGCTGCGCTGCCATGCTGGGTAGACGCGGCGCAGCTGGCttagccacagcaacagctgctgctgcagcgccaAATGCCGGACAACAGCCGGCGGCGCTCACATTGCAAGCGCCGCCAGGCACTCGCTTGTATTGGGCAGCGACGGGTCCGACATgcggtggcagcggcagcagcagtggcaacagcagcaatttaaatgctgccTTTAAtcttgccaacaacaataacaataacagcatgctaactaacaacaataacaacagcaacaacaatatcaatacaattaaaatgccgCTGCCGATTGTTTTGACAGCgccagcaaccgcagcagcagcagcggcgtcgTCGgtgtcgtcgtcgacgtcgcagCGACGCCACGAAACGCACGCATCGCGACGCTCAATAACAGGGCAAAAGCGACGCAATCCGAACCAcggcaataacagcagcagcagcagcagcaacaacagcagcaataacagcaagcAAAATGTTAGCAAAGGTGTTAGAaatgctactgctgctgctgctgcgaggACGGCGGCTGCACCgagcagcgctgctgctgcggaaaTACGCTGCGTGAACAGCGCCAGACTGACAAATTTCGGCAGtgcgcagctgcagctgcccgCAAAAACCATTAAATCAGAGCATTTGGAGTAG
Protein Sequence: MLDDDMQSLGTDDEDDDFISSEGSLYDGDLATTANDEIGHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVAPAVTTTTSQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAPQQQHQQQQHQQQQQHHHHHQQQQQQQQQQQHHQHQQQQQQHHHHHHHTTSGNNTVHIQAIGQAQPQTIQLTTASGTATATAVPTTAAAVSASSAAAAAAAAAQQAAQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANIQQLQTNSDGTVCLAPMQVDNSNSPNSSNSATRNTTNNSNNNISNNNNNNNTNNNNNNSSSSGSAAAPTSLLGISVINTGCAAMLGRRGAAGLATATAAAAAPNAGQQPAALTLQAPPGTRLYWAATGPTCGGSGSSSGNSSNLNAAFNLANNNNNNSMLTNNNNNSNNNINTIKMPLPIVLTAPATAAAAAASSVSSSTSQRRHETHASRRSITGQKRRNPNHGNNSSSSSSNNSSNNSKQNVSKGVRNATAAAAARTAAAPSSAAAAEIRCVNSARLTNFGSAQLQLPAKTIKSEHLE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00496330;
90% Identity: iTF_00592831;
80% Identity: -