Dcog010438.1
Basic Information
- Insect
- Drosophila cognata
- Gene Symbol
- sba
- Assembly
- GCA_035041535.1
- Location
- JAWNLC010000571.1:7926592-7934024[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 1.7 3.8e+03 -2.4 0.1 29 48 137 157 125 174 0.75 2 2 7.6e-09 1.7e-05 24.3 0.0 10 58 250 289 242 310 0.82
Sequence Information
- Coding Sequence
- ATGGCTGCCGCATCCGCTggccaacagctgcagcagcagcagcagcaacaacagactcagcacaaattgaacattgttggtgttggcaaTGCGGAGACGGTTGCTGGTGTGCTGCAGGTCACCAAtgagttgcaacagcaacagcaacagctcaacatgtacaagcaacagcagcaacagcaattgttgcagcaacagcaacatcaattcTATCAGCAGCAAACGAAATTTGTATCGCGGGTCGTTACAAATGCAGCCGCaatgcaaccacaacaacaacaacagcagcaacaaatattacCAGCTGGTTTGGTAAATGGCAGCGCCAACATGATGCAAGCCACAAATGTTGCtgtacagcagcagcagcaccaacaacagcagcaacaacaacagcaacaacaactgcgtcAAAGTcaacacatttttgtgtgtccATCAATAGGCAcgcaactacagcaacagcaacaacagcatcatcagcagcaacttcaacagcagcagcagcaaagcaaacagcGTTTAGCGCAAATCAAGTTGCCTGTAAAgtccgcagcagctgcagcagccgcagcagtcgcaacagcaactgttgctgccacgAACTGTatgccagcaacaattgcaatgcgTCAAATGAATCAGaaccatcagcaacagcagctctaTGCTAAGAATgtggccaaaaacaataatgctggcaccaacatcaacatcaacagcaacagcaacagcaataacaatgcaaatttggCTCCAGGCTGGCGTCGactaaccaacaacaatgaagtGGCCTACATCAGTCCAACGGGCAAAACGCTGCGAACGCAATTCCAAATTAAGGACTATTTGCTAACACAGGGTACCTGCAAGTGCGGCCTGCCGTGTCCGCTGAGGCCGGAATactttttcgattttaatgCACAGGTAAGTTAG
- Protein Sequence
- MAAASAGQQLQQQQQQQQTQHKLNIVGVGNAETVAGVLQVTNELQQQQQQLNMYKQQQQQQLLQQQQHQFYQQQTKFVSRVVTNAAAMQPQQQQQQQQILPAGLVNGSANMMQATNVAVQQQQHQQQQQQQQQQQLRQSQHIFVCPSIGTQLQQQQQQHHQQQLQQQQQQSKQRLAQIKLPVKSAAAAAAAAVATATVAATNCMPATIAMRQMNQNHQQQQLYAKNVAKNNNAGTNININSNSNSNNNANLAPGWRRLTNNNEVAYISPTGKTLRTQFQIKDYLLTQGTCKCGLPCPLRPEYFFDFNAQVS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00513461;
- 90% Identity
- iTF_00619836;
- 80% Identity
- iTF_00619836;