Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 5.2e-05 0.31 11.2 0.2 7 48 60 104 56 107 0.84

2 7 0.0054 33 4.7 0.4 21 45 108 132 102 136 0.84

3 7 0.0033 20 5.4 0.5 18 45 133 160 129 163 0.88

4 7 0.00053 3.2 8.0 0.5 18 45 161 188 157 191 0.88

5 7 0.002 12 6.1 0.4 18 44 189 215 187 219 0.91

6 7 0.00096 5.8 7.1 0.1 21 44 220 243 216 248 0.89

7 7 0.0062 38 4.6 0.3 21 44 248 271 245 277 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	5.2e-05	0.31	11.2	0.2	7	48	60	104	56	107	0.84
2	7	0.0054	33	4.7	0.4	21	45	108	132	102	136	0.84
3	7	0.0033	20	5.4	0.5	18	45	133	160	129	163	0.88
4	7	0.00053	3.2	8.0	0.5	18	45	161	188	157	191	0.88
5	7	0.002	12	6.1	0.4	18	44	189	215	187	219	0.91
6	7	0.00096	5.8	7.1	0.1	21	44	220	243	216	248	0.89
7	7	0.0062	38	4.6	0.3	21	44	248	271	245	277	0.84

Coding Sequence: ATGGCACAAACGATAGATGTGGCGTGCGTCAAGGAGGAGCACTGCGAGGCCATTTGCAATATGTTCAAGAATCAGGATTGGCAGTTGACGATGCGACACAGAGATTTGGGCCTGGTCAAGATCGAGCAGGACATGAGCTTCGTGTGGCAAAACAGCGCCAATGCCAACATGGACGGCAAGCAGCGTCCAGCAACAGAGAAGCAAACACTAAAAAAATTTCAGAGCGGCAGCGAAAAGCCCTTCAAGTGCGCCCACTGTCCCAAAGATTTTGCGACGAGCAGCAATCTTAAGGTGCATctgacacgcacacactccgGAGATCGCGAGCGACCCTTTCTCTGTCCCACCTGTCCCAAGTCCTTTGCGACAAATGATAATCTGCAGAAGCACATACGTCGGCATTCAAGCGAAAGGACACTCAGTTGCCCGCACTGCCCGAAGCTGTTTGCCACCAAGGACAATCTGCAGAAGCATATACGCCGCCACTCCAGCGAGCGGACGCTCACTTGTCCGCATTGTCCGAAGGCCTTTGCCACCAACGACAATCTGCAGAAGCACATCCGGCGCCATTCGAGCGAACGGACTCTCAATTGCCCACACTGCCCGAAGGCGTTCGCAACGAACGACAATCTGCAGCGACACATACGCGGGCACACGGGTGAGCGACCCTTCAAGTGTCCCTACTGCCCGAAACCCTTCGCCCAAAATCGAGATCTCAAAGCGCACATTCTGGAGCACACGGGCGAGAAGCCCTACAAGTGTCCACACTGTCCCAAGGCGTGCGTGCGCAGCGAGGGCCTGAAGAAGCACATACTGCGGCTGCACAAGGACATCGAACCGGAGCCGACGCAGACCACAGCCAAACACTGGCCAACGGACAAGACGTTTGCAGCGGACTCGAGCGGACGCGTCTTCATGTACAAATACGATCTGAGCAAGCAAACGCGCATGCCCACAGGCGAGGCGTAA
Protein Sequence: MAQTIDVACVKEEHCEAICNMFKNQDWQLTMRHRDLGLVKIEQDMSFVWQNSANANMDGKQRPATEKQTLKKFQSGSEKPFKCAHCPKDFATSSNLKVHLTRTHSGDRERPFLCPTCPKSFATNDNLQKHIRRHSSERTLSCPHCPKLFATKDNLQKHIRRHSSERTLTCPHCPKAFATNDNLQKHIRRHSSERTLNCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPYKCPHCPKACVRSEGLKKHILRLHKDIEPEPTQTTAKHWPTDKTFAADSSGRVFMYKYDLSKQTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2