Basic Information

Insect: Drosophila ananassae
Gene Symbol: zfh1
Assembly: GCA_017639315.1
Location: CM029943.1:607486-611602[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.3e-05 0.0018 18.6 1.0 1 23 154 176 154 176 0.97

2 15 0.00077 0.058 13.8 1.2 3 23 184 204 182 204 0.94

3 15 0.00023 0.018 15.4 0.2 1 23 357 379 357 379 0.98

4 15 0.00011 0.0083 16.4 0.5 1 23 385 407 385 407 0.99

5 15 3.2e-05 0.0025 18.1 1.6 1 23 438 460 438 460 0.97

6 15 0.0015 0.11 12.9 0.2 2 23 492 513 492 513 0.94

7 15 0.0093 0.71 10.4 1.3 1 23 519 542 519 542 0.97

8 15 0.023 1.7 9.1 0.4 3 19 551 567 550 568 0.95

9 15 0.00013 0.01 16.1 5.6 1 23 577 599 577 599 0.97

10 15 0.035 2.7 8.5 1.2 2 23 605 626 604 626 0.96

11 15 7.9e-06 0.0006 20.0 1.0 1 23 635 657 635 657 0.98

12 15 0.0009 0.068 13.6 0.1 3 23 665 685 663 685 0.97

13 15 4.8e-05 0.0037 17.6 0.5 1 23 691 713 691 714 0.95

14 15 0.0012 0.088 13.2 0.5 1 23 724 746 724 746 0.97

15 15 0.0045 0.35 11.3 0.3 1 23 1267 1289 1267 1289 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.3e-05	0.0018	18.6	1.0	1	23	154	176	154	176	0.97
2	15	0.00077	0.058	13.8	1.2	3	23	184	204	182	204	0.94
3	15	0.00023	0.018	15.4	0.2	1	23	357	379	357	379	0.98
4	15	0.00011	0.0083	16.4	0.5	1	23	385	407	385	407	0.99
5	15	3.2e-05	0.0025	18.1	1.6	1	23	438	460	438	460	0.97
6	15	0.0015	0.11	12.9	0.2	2	23	492	513	492	513	0.94
7	15	0.0093	0.71	10.4	1.3	1	23	519	542	519	542	0.97
8	15	0.023	1.7	9.1	0.4	3	19	551	567	550	568	0.95
9	15	0.00013	0.01	16.1	5.6	1	23	577	599	577	599	0.97
10	15	0.035	2.7	8.5	1.2	2	23	605	626	604	626	0.96
11	15	7.9e-06	0.0006	20.0	1.0	1	23	635	657	635	657	0.98
12	15	0.0009	0.068	13.6	0.1	3	23	665	685	663	685	0.97
13	15	4.8e-05	0.0037	17.6	0.5	1	23	691	713	691	714	0.95
14	15	0.0012	0.088	13.2	0.5	1	23	724	746	724	746	0.97
15	15	0.0045	0.35	11.3	0.3	1	23	1267	1289	1267	1289	0.97

Sequence Information

Coding Sequence: ATGAACAACCAGGGCTATGGCGGCATCCAGTGGATCCAGCACTCCACCGCGCCGGACGTCTGCGAGGTGGAAGTCCTAGAAAACGGAGCCGAGATGGCCGTTCAAGAGGCGGCGGCGGCGTTCGTCGACGACGGCGGCGAGGAGGATGCCGAGGAGGACCTGGACCATATGGCTGCCGAGAACCTCATCTTCATGGCGCGCGACGGCCAGCTGAGCGAGATCATAGCCGCCAACGAGGCTGGGGGGGCCGTCCTGGTCACCGCCGACGGCACCACCGTGGCCTACGCAGGCTCCTTCGACGACGACGCCCAGGTGGTCACCGAGGAGGTCATCACAGACGACTGGGTGCAGCACCAGGGGGCCGAGCGAGTGGAGATCGCCGCGGAGCAGATAGCTGGAATTAGCAGCTCGCAGGAGCTGCTGGACATGGAACAGGACGAGTACACCGCCCTCCGGCCGTATCCCTGCGACTTCTGCAGCCGCCGTTTCCGGAAGAAGGCCAGCCTGAACAACCACATGCTGGCGCACCAGAACGACAGGCCGCACCTCTGCAAGCTCTGTGGCGCTCGTTTCACGCGACGCGCGGAGCTCATCAGCCACTTCAAGGCCCACGCCGAGGCCCAAGATGCGGCAGACGCTGAGGCGGCGGCAGCAGCAGCAGCGGCAGCGGTCTCAGCTTCTTCCATTAAATACGAGTACCAGAGCCAGCGGCAGCTGGATGAACACTTTTACGAGCAGGAGTGGTCGCTGAGCCATCAGGACCAGGGCCAGGTGCGTCACGAGCAGCACAACCATTCGGAGCAGCAACTTATCTCCAACCACGACGTGGCGGACGCCTACCCGGCCCTGGTGGCCCCGCCAGCTGCTCCTGCGCGCGGCAGGATCAGCAGGCTCAAGCCAAAAGAGGAGAGCAGCCAGTTCATAGTGATGGCCGAGAGGCAGTCGAGCCCCAACTTGGGTAGCAATTGCCTCTCGCCAACGGAGCAGCCAACGGTGGCCTCCGCCCAGTCCGGGACTGCCGAGCCTCCGCCCCAGCCCAACTATCCCATTTTGGACGACAAGAAGCCGTTTGTATGCCAGCAGTGCGGCCTGGCCTTTGCCCGGGAGAAGGCACTGGTGTCGCATACGAAGAACCACCGCATGGACTCGCCGTATGAGTGCAACCAGTGCCAGGAGATGTTCTGGGACAACAGCAGCCTGCAGGAGCACCTCAAGACCCACCAGTTCGAAGAGAGCAACTCGGAGTACGACCCCGCCTCCGCGGAGGACTCTGCCAGTGAGTCGGAGCCGGAGGAGCAGCTGTATGGGGACTTCTACTGTGCCGAGTGCGGCATTTCGTTCCATCGCCAGGACCTGTTGCGGCGCCACGCGAAGCAGCACATCAAACAGCCCGAAGCACAGGCGGGAGAGAGGAACTCTACCGTCGCTGCTGGGGGGGAAGTGGATGCCAAAGAGTCCAGCGGTGGGGGCAACAGCTGCCACACCTGCGGAAAGTCTTTTCCCACTGCCCTGGAGATGCTGGCCCACGCCGAGATCCACTCACGGTTCCCGCCGTTCAAGTGCGTGCTCTGCGGCATCAGCTTCTACGAAGAGCAGGCCATCAAGCGACACCTCCACACCCGCCACCCCAACGAGCTGAAGGCCAACTCGTGCGTTCTGTGCGGCAAGGAGTGCCGCGACCGGAAGGCCTTGATCAAGCACGCCTGGGACCACTCCCGCGAGAAGTGCCACTCGTGCTCGAAGTGCGGCAAGAACTTCCACAACAAGGCCCGCTTGAAGCGGCACATGGCCTCGCACCGCGACAAGTCGGTGGTGTGCGAAGTGTGCCACGAGGAGTTCCCGGACGGGCGCACTCTTTCCAACCACCGCCACTCTCACAGCACTACCTCGCCGGGCAAGCTCTTCCCGTGCCACGAGTGCGGCAAGACTTTCGGGTCGCGCAGCTCGCAGCAAATCCATGTGCGCATTCACACGGGCGAGAGACCTTACGGGTGCCGCTACTGCTGGAAGGCCTTCGCGGACGGAGGCACTCTGCGAAAGCACGAGCGGATCCACACGGGCGAGAAGCCCTACGCCTGCTCGGTCTGCCCGCGCGCCTTCAACCAGCGGGTGGTGCTGCGCGAGCACATTCGCTCGCACCACTCCGGCTTGGACGTGGCTCGCAACACGTACCACTGCACGGTCTGCTCCGAGGACTTCCCCTCGTCCAACGACCTGATCCAGCACCTCATTCAGCACAGCGACTCGAACACTGCGAAGCAGCGACAGCCGATCACCGGACCCCGCAAGTACAAAAGGCGCCGCAAGCTGCAGCCGCACGAGATCGTTCAGATGCGGGCGGAGAGCAAGGAGGCCAACGGCGAGGGGGAGGCCTTGGGGGAGGCGGACCGCGATGGCGAGGAGGACGACTACGCAAGTGACATTGATATCTGCGACTTCGACGTGGACCAAGTGGACGATTCGCTGTTCGACATAGCGGAGTCCCCCAAGAAGGAGAAGCGCAAGCGGACGTCGGCCAGGACGGTTCCCAAACATAATGCTTCAAACGGTGGTGCGGGCACAACGGGTGGAGATGGCTCGGGCAAGCCGACTCAGTCGAAGGAAAACACAAAGCTGCGATACGACTCCACGAGCAGTCAGCAATCGGACCGGATCTGGGAGGAGAAGTTCCTGCAGGACAGCCAGACTCCGCTCTTCCAGATAGACTCGTTGGTGGTGGTCAACGACACCCCGCTCCCTCCCGCCAGTCCCAGCGAGTCTGCAGCGCTGCCCAAAACCAGAGCTGCAGCGAAGCTACTCTCCAAGCCGGCGGAAGCCTCGACCAGCGCCACTGTGTCTTCCTACTCGGCCGCGTCCGTTAGTCGCGGCAGGAAGAAGCCCGCTAGCAAGACCGCAGGCAAGGCGCCGTCTGCCATCAGCAGCTCCTCCCGCCCTCGAATGATCCACACGGAGAGGGCCAGGGTTACGAAGCCGGCGGTGGGCACTGATTCCTCCTCTAAGAAGACGCGCTCGAAGGTGTACGTCACTCGCACGGAGACCACCAGCAAGTTGGGTGCGCTCGATAAGTCCTGCATTGTGGACGACTACGAGATCATCTCTCCGGCCACCCAGCCGCCCAACCAAATCAGCTCGAGTCCTCTGCACATCAAGCAGGAACAGGAGCACCAGCAGCAGCGGGTGCAGCTGATGTACGACGACAACCTGCTGATCGACGCCGCGTTGCTGCGAGAGAAGACCTACGAGAAGTTCAACCCCAGCATAGTCAACGATCTGGAGGAGATCCTGCGCTCGCCACTAAAGCACGACCGCAGCTCGCGTCTGCGCTTCACCAGCGAGTCCTCGACCACACCGCAGTTCCTGCCAGAGGAGGAGCAACACCTGATCAAGATCGAGCCCACCTCGCCGGATCTGAGGGAAATGGTGGAGAGCCAGACGAGAGTCACTTCGTCATCGTCCTCGTCGGCCAGAACCTCGCGACACTTGCGCCAAATCACTGCCAACAATGGGCCGAGGGCGGGGAGCCAGCGGTTCGCAGAGAAGTCGTCCCCCGGCGCAGGAGGTGCGCACAAGAAGGCGACCTCCTCCGCCTCGACTGTCAGCAAAGTGGGCTCCTCCTCCTCGTACCTGGGGTATGGGGTGGAGGCGTACAGCGTGAACCAATGCGTACCTGCCAGCGGAAGCACTGCCGACGTGGGCAGCGGTTTCTTCTCCATTTCGGAAGTGGTCTCCGCCGCGGATGCCGCAGACGCTGCGGCCAAGGCGGCGGCGGCCGGGAAGTCCGAGCGGAAGACGCGCTTCTTCGAGTGCGAGATGTGCACCGCCATCTTCTACGACCGGGCCCAGCTGCTGGAGCACGTGCACATCCACATCTAG
Protein Sequence: MNNQGYGGIQWIQHSTAPDVCEVEVLENGAEMAVQEAAAAFVDDGGEEDAEEDLDHMAAENLIFMARDGQLSEIIAANEAGGAVLVTADGTTVAYAGSFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFTRRAELISHFKAHAEAQDAADAEAAAAAAAAAVSASSIKYEYQSQRQLDEHFYEQEWSLSHQDQGQVRHEQHNHSEQQLISNHDVADAYPALVAPPAAPARGRISRLKPKEESSQFIVMAERQSSPNLGSNCLSPTEQPTVASAQSGTAEPPPQPNYPILDDKKPFVCQQCGLAFAREKALVSHTKNHRMDSPYECNQCQEMFWDNSSLQEHLKTHQFEESNSEYDPASAEDSASESEPEEQLYGDFYCAECGISFHRQDLLRRHAKQHIKQPEAQAGERNSTVAAGGEVDAKESSGGGNSCHTCGKSFPTALEMLAHAEIHSRFPPFKCVLCGISFYEEQAIKRHLHTRHPNELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDFPSSNDLIQHLIQHSDSNTAKQRQPITGPRKYKRRRKLQPHEIVQMRAESKEANGEGEALGEADRDGEEDDYASDIDICDFDVDQVDDSLFDIAESPKKEKRKRTSARTVPKHNASNGGAGTTGGDGSGKPTQSKENTKLRYDSTSSQQSDRIWEEKFLQDSQTPLFQIDSLVVVNDTPLPPASPSESAALPKTRAAAKLLSKPAEASTSATVSSYSAASVSRGRKKPASKTAGKAPSAISSSSRPRMIHTERARVTKPAVGTDSSSKKTRSKVYVTRTETTSKLGALDKSCIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQQRVQLMYDDNLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHDRSSRLRFTSESSTTPQFLPEEEQHLIKIEPTSPDLREMVESQTRVTSSSSSSARTSRHLRQITANNGPRAGSQRFAEKSSPGAGGAHKKATSSASTVSKVGSSSSYLGYGVEAYSVNQCVPASGSTADVGSGFFSISEVVSAADAADAAAKAAAAGKSERKTRFFECEMCTAIFYDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00481669; iTF_00550378; iTF_00615697; iTF_00477463; iTF_00580108; iTF_00546096; iTF_00504122; iTF_00615035; iTF_00488151; iTF_00566225; iTF_00539097;
90% Identity: iTF_00580108;
80% Identity: -