Basic Information

Insect: Drosophila malerkotliana
Gene Symbol: zfh1
Assembly: GCA_018153235.1
Location: JAECXV010000008.1:570475-574589[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.3e-05 0.0017 18.6 1.0 1 23 154 176 154 176 0.97

2 15 0.00075 0.055 13.8 1.2 3 23 184 204 182 204 0.94

3 15 0.00023 0.017 15.4 0.2 1 23 354 376 354 376 0.98

4 15 0.00015 0.011 16.0 0.6 1 23 382 404 382 404 0.98

5 15 2.7e-05 0.002 18.3 2.4 1 23 435 457 435 457 0.97

6 15 0.0032 0.24 11.8 1.0 3 23 490 510 489 510 0.94

7 15 0.059 4.3 7.8 1.8 1 23 516 539 516 539 0.97

8 15 0.022 1.6 9.1 0.4 3 19 548 564 547 565 0.95

9 15 0.00013 0.0097 16.2 5.6 1 23 574 596 574 596 0.97

10 15 0.04 2.9 8.4 0.4 2 23 602 623 601 623 0.96

11 15 7.8e-06 0.00057 20.0 1.0 1 23 632 654 632 654 0.98

12 15 0.00088 0.065 13.6 0.1 3 23 662 682 660 682 0.97

13 15 4.7e-05 0.0035 17.6 0.5 1 23 688 710 688 711 0.95

14 15 0.0011 0.083 13.2 0.5 1 23 721 743 721 743 0.97

15 15 0.0046 0.34 11.3 0.3 1 23 1262 1284 1262 1284 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.3e-05	0.0017	18.6	1.0	1	23	154	176	154	176	0.97
2	15	0.00075	0.055	13.8	1.2	3	23	184	204	182	204	0.94
3	15	0.00023	0.017	15.4	0.2	1	23	354	376	354	376	0.98
4	15	0.00015	0.011	16.0	0.6	1	23	382	404	382	404	0.98
5	15	2.7e-05	0.002	18.3	2.4	1	23	435	457	435	457	0.97
6	15	0.0032	0.24	11.8	1.0	3	23	490	510	489	510	0.94
7	15	0.059	4.3	7.8	1.8	1	23	516	539	516	539	0.97
8	15	0.022	1.6	9.1	0.4	3	19	548	564	547	565	0.95
9	15	0.00013	0.0097	16.2	5.6	1	23	574	596	574	596	0.97
10	15	0.04	2.9	8.4	0.4	2	23	602	623	601	623	0.96
11	15	7.8e-06	0.00057	20.0	1.0	1	23	632	654	632	654	0.98
12	15	0.00088	0.065	13.6	0.1	3	23	662	682	660	682	0.97
13	15	4.7e-05	0.0035	17.6	0.5	1	23	688	710	688	711	0.95
14	15	0.0011	0.083	13.2	0.5	1	23	721	743	721	743	0.97
15	15	0.0046	0.34	11.3	0.3	1	23	1262	1284	1262	1284	0.97

Sequence Information

Coding Sequence: ATGAACAACCAGGGCTATGGCGGCATCCAGTGGATTCAGCACTCCACCGCGCCGGACGTTTGCGAGGTGGAAGTACTAGAAAACGGAGCCGAGATGGCCGTTCAAGAGGCGGCGTCGGCGTTTGTAGACGATGGCGGCGAGGAGGATGCGGAGGAGGACCTGGACCATATGGCTGCCGAAAACCTCATCTTCATGGCTCGCGAAGGTCAGCTCAGCGAGATCATAGCTGCCAACGAGGCTGGTGGGGCCGTCCTGGTCACCTCCGATGGCACGACCGTGGCCTACGCAGGGGCCTTCGACGACGACGCTCAGGTGGTCACCGAGGAGGTCATCACAGACGACTGGGTGCAGCACCAGGGGGCCGAACGCGTGGAAATCGCCGCAGAGCAGATAGCTGGAATAAGCAGCTCGCAGGAGCTGCTGGACATGGAACAGGACGAGTATACCGCCCTCCGCCCATATCCCTGCGACTTCTGCAGCCGCCGCTTCAGGAAGAAGGCCAGCTTGAACAATCACATGCTGGCGCACCAGAACGACAGGCCACACCTTTGCAAACTTTGTGGAGCTCGATTCACGCGGCGCGCAGAGCTAATCAGCCACTTCAAGGCCCACGCCGAGGCCCAAGATGCGGCAGATGCTGAGGCGGCAGCAGCAGCAGCAGCGGCGGCAGCGGCAGCCGTGCCAGCTTCTTCCATCAAATTCGAGTACCAGACCCAACGGCAGTTGGATGACCACTTTTACGAGCAGGAGTGGTCGCTCGGCCATCAGGATCAGGGTCCAGTGCGACATGATCAGCACAATCATTCGGAGCAGCAACTTATCTCCAGCAACGACTTGACGGATGCCTATCCGTCCGTGGCACCTCCAGTGGCTCCTGCGCGCGGCAGGATCAGCAGGCTGAAACCCAAGGAGGAGAGCAGCCAGTTTATCATGATGGCCGAGGGACAGTCGAGCCCCTACTTGGGCTGTGACCAGGAGCAACCAAAGGCCTCCGCCCAATCCGGTACTTCCGAACCTCCGCCTCAGCCCAACTATCCCATTCTGGACGATAAGAAGCCGTTCGTGTGTCAGCAGTGTGGTCTGGCCTTCGCCCGTGAAAAGGCGCTGGTGTCGCATACGAAGAACCACCGCATGGACTCGCCGTTCGAGTGCAACCAGTGTCAGGAGATGTTCTGGGACAACAGCAGCCTGCAGGAGCACCTCAAGACCCACCAGTTCGAAGAGAGCAACTCGGAGTACGACCCCGCCTCTGCGGAGGACTCTGCCAGTGAATCGGAGCCGGAGGAGCAGCTGTATGGCGACTTTTACTGTGCCGAGTGCGGCATTTCGTTCCACCGCCAGGACCTGTTGCGGCGCCACACGAAGCAACATACAAAACAGCCCGAAACACCGGCTGGAGAGAGGAACACAACCGTCGCTGCTGGTGGGGAAGTGGATGCCAAAGAGTCAAGCGGGGGAGGTAACTGCTGCCACACCTGCGGCAAATCTTTTCCCACTGCCCTGGAGATGCTCGCCCACGCTGAGATCCACTCGCGGTTCCCACCCTTCAAGTGCGTCCTCTGTGGCAGCAGCTTTTACGAGGAGCAGGCCATCAAGCGACACCTTCACACCCGCCACCCCAACGAGCTGAAGGCCAACTCGTGTGTTCTGTGCGGCAAGGAGTGCCGCGATCGGAAGGCCTTGATCAAGCACGCCTGGGACCATTCCCGCGAGAAGTGCCACTCTTGCTCGAAGTGCGGCAAGAACTTCCATAACAAGGCGCGCTTGAAGCGACACATGGCGTCGCACCGCGACAAGTCGGTGGTGTGTGAGGTGTGCCAAGAAGAGTTCCCGGATGGGCGCACCCTCTCCAACCACCGCCACTCCCACAGCACCACCTCGCCGGGCAAGCTCTTCCCTTGCCACGAGTGCGGCAAGACTTTCGGGTCGCGCAGCTCGCAGCAGATCCATGTGCGCATACACACGGGGGAAAGACCCTACGGATGTCGCTACTGCTGGAAGGCCTTCGCCGATGGAGGAACTCTGCGAAAGCACGAACGGATCCACACTGGCGAGAAGCCGTACGCTTGCTCGGTCTGCCCGCGAGCCTTCAACCAGCGGGTGGTGCTGCGCGAACACATTCGCTCGCACCACTCGGGCCTGGACGTGGCTCGGAACACGTACCACTGCACGGTCTGCTCCGAGGACTTTCCCTCGTCTAACGACCTCATCCAGCACCTTATTCAGCACAGCGACTCGAACACTGCCAAGCAGCGACAGCCAATCACCGGACCTCGTAAGTACAAGAGGCGCCGCAAGCTTCAGCCGCACGAAATCGTTCAAATGCGGGCGGAAAGCAAGGAAGCCAATGGCGAGGAGGAAGCCCTGGGTGAGGCGGATCGCGATGGCGAGGAGGATGACTACGCCAGTGACATTGACATCTGCGACTTCGACGTGGGCGATGTGGGCGATGTGGACGAACTATTCGACATAGCCGAGTCCCCCAAGAAGGAGAAGCGCAAGCGCACATCGACAAAAGCAGTTTCTAAGCACAATGTTTCAAACGGAGGTGCGGGCACAACAGGAGGAGATGGCTCGGCAAAGCCGACTCAGTCTAAGGATAACACAAAGCTGCGATACGATTCCACAAGCAGTCAACAGTCGGACCGCATCTGGGAGGAGAAGTTCTTGCAAGACCATCAAGCTCCGCTTTTCCAGATAGATTCGTTGGTGGTGGTCAACGACACTCCGCTTCCGCCCACCAGTTCCAAAGAATCCACAGCGGTGCCCAAAACCAGAGCTGCAGCGAAGCTACTCTCCAAGCCGGCGGAAGCCTCGACCAGCACGACTTCGACCTCGTCATTGAGTCGTGGCAGGAAGAAACCGACTAACAAGACCTCAAGCAAGGCACCATCCGCCGCCAGCAGTTCCTCACGCCCCCGTATGATTCACACGGAGAGGGCCAAGGTCACAAAGTCGGCGGTAGGCCCTGAATCCTCCTCCAAGAAAACGCGCTCCAAGGTGTACGTCACGCGCACAGAGACTGCCAGCAACATGAGTGCGCTCGAAAAGTCCTGCATTGTGGACGACTACGAGATCATCTCTCCGGCCACCCAGCCGCCCAATCAAATCAGCTCCAGTCCCCTGCACATCAAGCAGGAGCAGGAGCACCAGCAGCAGAGGGTGCAGCTGATGTACGACGACAACCTTCTGATTGACGCCGCTCTGCTGCGGGAGAAGACCTACGAGAAGTTCAACCCCAGCATCGTGAACGATCTGGAGGAGATTCTGCGCTCGCCGCTGAAGCACGACCGCAGCTCCCGCCTGCGCTTTACCAGTGAATCCTCGACTACGCCGCAGTTCCTGCCTGAGGAGGAGCAAAACCTGATCAAAATCGAGCCCACCTCGCCGGACCTGCGGGAAATGGTGGAGAGTCAGCAGCGAGTCACTTCATCATCCTCCTCGTCAGCCAGAACCTCACGGCACTTGCGTCACATCACTGCCAACAACGGGACGCGGGCGGGGAGCAAGCGCTTCGCAGAAAAGTCGTCTCCCGGCGCAGGAGTTTCGAACAAGAAGGGGTCCTCCTCCGCCTCAGCTGTCAGCAAAGTGGGCTCCTCCTCCTCGTACCTTGGGTACGGGGTGGAAGCGTATATCGTGAACCAATGCGTACCTGCCAGCGGAAGTACTGCCGACGTGGGCAGCGGTTTCTTCTCCATTTCGGAAGTGGTCTCCGCCGCAGATGCCGCGGACGCTGCGGCCAAGGCGGCGGCGGCCGGAAAGTCGGAGCGGAAGACGCGCTTCTTCGAGTGTGAGATGTGCACCGCCATCTTCTACGATCGGGCCCAGCTGCTGGACCACGTGCACATCCACATCTAG
Protein Sequence: MNNQGYGGIQWIQHSTAPDVCEVEVLENGAEMAVQEAASAFVDDGGEEDAEEDLDHMAAENLIFMAREGQLSEIIAANEAGGAVLVTSDGTTVAYAGAFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFTRRAELISHFKAHAEAQDAADAEAAAAAAAAAAAAVPASSIKFEYQTQRQLDDHFYEQEWSLGHQDQGPVRHDQHNHSEQQLISSNDLTDAYPSVAPPVAPARGRISRLKPKEESSQFIMMAEGQSSPYLGCDQEQPKASAQSGTSEPPPQPNYPILDDKKPFVCQQCGLAFAREKALVSHTKNHRMDSPFECNQCQEMFWDNSSLQEHLKTHQFEESNSEYDPASAEDSASESEPEEQLYGDFYCAECGISFHRQDLLRRHTKQHTKQPETPAGERNTTVAAGGEVDAKESSGGGNCCHTCGKSFPTALEMLAHAEIHSRFPPFKCVLCGSSFYEEQAIKRHLHTRHPNELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDFPSSNDLIQHLIQHSDSNTAKQRQPITGPRKYKRRRKLQPHEIVQMRAESKEANGEEEALGEADRDGEEDDYASDIDICDFDVGDVGDVDELFDIAESPKKEKRKRTSTKAVSKHNVSNGGAGTTGGDGSAKPTQSKDNTKLRYDSTSSQQSDRIWEEKFLQDHQAPLFQIDSLVVVNDTPLPPTSSKESTAVPKTRAAAKLLSKPAEASTSTTSTSSLSRGRKKPTNKTSSKAPSAASSSSRPRMIHTERAKVTKSAVGPESSSKKTRSKVYVTRTETASNMSALEKSCIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQQRVQLMYDDNLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHDRSSRLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVTSSSSSSARTSRHLRHITANNGTRAGSKRFAEKSSPGAGVSNKKGSSSASAVSKVGSSSSYLGYGVEAYIVNQCVPASGSTADVGSGFFSISEVVSAADAADAAAKAAAAGKSERKTRFFECEMCTAIFYDRAQLLDHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00476060;
90% Identity: iTF_00580108;
80% Identity: -