Dana009136.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila ananassae
Gene Symbol
egg
Assembly
GCA_017639315.1
Location
CM029942.1:12025342-12029558[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.9e-15 1.7e-11 43.5 0.0 5 75 830 893 827 895 0.90

Sequence Information

Coding Sequence
ATGTCGACGAAGCCAGAAGCCATGGATTGTGCGGACGTCACGGAAATCGCAAATGAGGATGGCCAAGGAACGGAAACATCACTCATAGCGGAGAAAGATGCCGGCTCGCCGAGTGTTGTCGAAAAAATTGATGCTGAGCCCACTGTGCTGGAAGAAAAGGGGAAACCCACTATTGAAGACGATGTGGAGATGGCGGACCTAACGTCTGAAGAACCATCTCTGATGCATGCAGACAATAATCCTGCCCATGCAGTTTCCGACAAATCCAAGGGAGACCTTGCCTGTGGTTCGCCGGCTGAGGTCGAAACTAGTAAAGTAGAGGAAGTTGGCCCTGTCGAGATCGATTCAGACAGCAGCGTCGAGGTAATAGATAGTCCAGTCAAGTCCCCTCCCTCCAATAAATCTGGGGAGGAGCACAAACAAGCCGCAGAAGAATCGCCGCCGAAGGGTCTCGTTACCGATGCTAAGGAGGGAAAAAACGATGAGGGCGACATGCCAGACAGTAGTATTGAACTTATCAGCAGTCCCACCTCAGAAGATTCTGCTGGCAGAGATCAACCAAAAGAAGTCAAGAAGCAGGAGGAGGAGAAGGCGGCTTCTGCAGAAATATCCATGGACATGGATCACGGCACACCGAGGGAAAGCGAAATGGACGGGGCACCTAAGCCTGCTGAGACTGATGAAGCCCTAGCTCCCGAAAACAACAAAATTGGGCTTGAGGTCGACCTCGAAAATAAGGCAATACCACAATCACTTGACTTGGAACAAACTAACCTCACGTGGAACGGCGATATATTTTATGGCAAAGATTGCGTCAATTGCAACTGCAAGCGGCTCCACAAGCAGTTCGTGCTGGCCAATATGGCCACCTTGAACTTTTACAAAGTTACCAGGAAGGTTTCCAAGCAGCAGTTCGTCTGCACTGGATGCGGCGATGCAGCCATGGAGATGTATGAGCAATACGCTGGTCAGCTGATGGCCAAGCAACCTTTATTGCTGCAGGAGTTCCATCAAGATCAAGCCGAGTTTGTGGCTCTGGATAGTAGCGATGAGGAGGAGGAGGAGAAGCAAGTAGAGGAAAAGCCAGAGTTTTCCACAAACGATCTGAACCTGATTGAAAATGAATTGGAGGACGCCATTGCAAGTGTGCTCAACCGGGTGGGGTTCCAGGACCAGCTTAGCTGGTCCAAGTCCATCCTACTGGCCAGGGCGGAGCGCTTGGAGCGCCAGTTTGAATTGGCCGACAAGGAACTGGAGGCGGTACAGAGCACCGCCGATAAAATGCACTGGGCCCTTTACAATTCCTGCACGGTGGTGCACAAGCACTTGCCGGCCCTGGATCTTCAACACAACATAGGCGACTATATGCAGCAAGTCCCTCCAGCAGGGGAAATCGAGCGACCGCCTATCCAGATTGGGGAGACTTACTACGCCGTTAAGAATAAGGCTATAGCCAGCTGGGTGTCCATAAAGGTGATCGAGTTCACGGAGAGCACGGCCATCGGTGGGAACACGATGAAGAGCTACAAGATCAAGTATCTGAATACCCCATACCAGATGGTAAAGACAGTGACGGCCAAGCACATAGCTTACTTTGAGCCGCCGCCAGTGCGCCTTACAATTGGCACCCGAGTGATCGCTTACTTTGACGGCTCTACTCTGAGCCGAGGAAAGGACAAAGGCGTTGTGCAAAGCGCGTTCTATCCGGGAATTATTGCCGAGCCGCTGAAGCAGGCAAATCGGTTCAGATACCTTATATTCTACGATGATGGATACACGCAGTATGTGCAGCATCGGGATGTTCGTCTGGTGTGCCAGGCCTCGGAAAAGGTTTGGGAGGATGTGCACCCCGCGTCTCGCGACTTTATCCAGAAGTACGTGGAAAAGTATTCGGTTGACAGGCCCATGGTGCAGTGTACCCGCGGCCAGAGCATGAACACCGAGTCGAACGGCACCTGGCTTTACGCGCGCGTCATTGACATTGACTGTAGCCTGGTCCTGATGCACTTTGAGGCGGACAAAAACCACACCGAGTGGATTTACAGAGGCTCCTTGAGACTCGGTCCGGTATTTAAGGAAACTCAGAATGCCATGAGCAGTGCCAACGCGCACCACGCGCGAGTACCAAGGCGCACAGAACCTTTCATTCGCTACACCAAGGAGATGGAGTCGAGCAACATGCAGGTGAACCAACAAATGCGGGCCATGGCCCGCAAAAGCAGCTCCGTCGCGCAAGGCGCAGTTACCTCAGCAGCGTCATCATCTTCGGCCAATACTTCGGCTGCCGGCCGCAGTGGCGGAGGAAATGCTAGCCGCGGGCCCGTCAAGCATTTAAACAATTCGACCATATACGTCGACGACGAGAACCGCCCCAAGGGCCATGTTGTTTATTTTACGGCCAAACGCAACCTGCCGCCTAAGGTGTATCGCCACCACGAGTGCAACCCGAACTGTTTGTTCAAGATCGTCCACCGTCTCGACAGTTACAGCCCACTTGCTAAACCCCTGCTGTCCGGCTGGGAGCGCCTGGTGCTGCGCCAAAAGACTAAAAAGAACGTTGTGTACAGGGGACCCTGCGGCAAAAGTCTGCGCAACTTGGCGGAGGTACACACCTACCTTCGAGCCACCGAAAATGTCCTGAATGTGGATAACTTTGACTTCACGCCGGATTTGAGGTGTTTGGCTGAATACTCAATCGATCCCACGATTGTCAAAGAGGCGGACATATCTAAGGGCCAGGAGAAAATGGCCATCCCGTTGGTCAACTACTACGACAACTCCCTGCCTCCTCCATGTACCTACGCCAAGCAGAGAATCCCCACCGAGGGAGTGCACTTGAATCTTGATGAGGAATTCCTTGTCGGTTGCGATTGCGATGACGACTGCTCGGACAAGTCCAAGTGCTCCTGCTGGCAACTGACTGTGGCTGGTGTCAAGTACTGCAACCCCAAAAAGCCCATCGAAGAGATCGGATACCAGTATAAGCGGTTGCACGAGCATGTGCCCACTGGCATTTATGAGTGCAACTCACGCTGTAAATGCAAAAAGAACTGCCTCAACCGAGTAGTGCAACACTCGCTGGAGATGAAATTGCAGGTTTTTAAGACCTCTAATCGAGGCTGGGGGCTGCGATGCGTTAACGACATCCCCAAAGGCGCCTTTATATGCATCTACGCTGGCCACCTGCTCACAGAAACGATGGCCAATGAGGGTGGCCAAGATGCTGGTGACGAATACTTCGCCGATTTGGACTACATCGAAGTGGCCGAACAACTAAAAGAGGGCTACGAGTCGGAGGTTGAGCAATCCGAGCCTGAACCAGAGGAAGATTCTTATCTGCCGGAAGCCGAAGACGACGATGATTTCCGACCAAACAACTACTATCAGAAGAAGAACAAGTTGCGCCCCACACGCAGTAATAGCGCCTCAGCCCAATCCACAGAAGTAGACTCGCAGGAGCGAGCGGTTATCAACTTCAACCCGAACGCTGATCTGGACGAGACAGTGCGAGAGAACTCTGTACGGCGGCTGTTTGGCAAGGATGAGGCGCCATACATTATGGATGCTAAAACAACCGGAAACCTGGGGCGCTACTTTAACCACTCGTGCAACCCTAATCTTTTCGTTCAAAACGTCTTCGTTGACACCCACGACCTGCGTTTTCCTTGGGTGGCATTTTTTTCGGCCTCCCACATACGCTCCGGCACAGAACTGACCTGGAACTACAACTACGAAGTGGGCGTGGTGCCCGGCAAGGTGTTATACTGCCAGTGTGGAGCCCCTAACTGCCGCATACGCTTGCTTTAA
Protein Sequence
MSTKPEAMDCADVTEIANEDGQGTETSLIAEKDAGSPSVVEKIDAEPTVLEEKGKPTIEDDVEMADLTSEEPSLMHADNNPAHAVSDKSKGDLACGSPAEVETSKVEEVGPVEIDSDSSVEVIDSPVKSPPSNKSGEEHKQAAEESPPKGLVTDAKEGKNDEGDMPDSSIELISSPTSEDSAGRDQPKEVKKQEEEKAASAEISMDMDHGTPRESEMDGAPKPAETDEALAPENNKIGLEVDLENKAIPQSLDLEQTNLTWNGDIFYGKDCVNCNCKRLHKQFVLANMATLNFYKVTRKVSKQQFVCTGCGDAAMEMYEQYAGQLMAKQPLLLQEFHQDQAEFVALDSSDEEEEEKQVEEKPEFSTNDLNLIENELEDAIASVLNRVGFQDQLSWSKSILLARAERLERQFELADKELEAVQSTADKMHWALYNSCTVVHKHLPALDLQHNIGDYMQQVPPAGEIERPPIQIGETYYAVKNKAIASWVSIKVIEFTESTAIGGNTMKSYKIKYLNTPYQMVKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGSTLSRGKDKGVVQSAFYPGIIAEPLKQANRFRYLIFYDDGYTQYVQHRDVRLVCQASEKVWEDVHPASRDFIQKYVEKYSVDRPMVQCTRGQSMNTESNGTWLYARVIDIDCSLVLMHFEADKNHTEWIYRGSLRLGPVFKETQNAMSSANAHHARVPRRTEPFIRYTKEMESSNMQVNQQMRAMARKSSSVAQGAVTSAASSSSANTSAAGRSGGGNASRGPVKHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKVYRHHECNPNCLFKIVHRLDSYSPLAKPLLSGWERLVLRQKTKKNVVYRGPCGKSLRNLAEVHTYLRATENVLNVDNFDFTPDLRCLAEYSIDPTIVKEADISKGQEKMAIPLVNYYDNSLPPPCTYAKQRIPTEGVHLNLDEEFLVGCDCDDDCSDKSKCSCWQLTVAGVKYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQHSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVEQSEPEPEEDSYLPEAEDDDDFRPNNYYQKKNKLRPTRSNSASAQSTEVDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCNPNLFVQNVFVDTHDLRFPWVAFFSASHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRIRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00615555; iTF_00550246; iTF_00481535; iTF_00545960; iTF_00503984; iTF_00614900; iTF_00477331; iTF_00579974; iTF_00488013; iTF_00566083; iTF_00538957;
90% Identity
iTF_00550246; iTF_00481535; iTF_00477331;
80% Identity
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