Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 3.2e-06 0.023 14.5 0.1 6 48 70 112 65 115 0.88

2 7 0.0063 46 4.0 0.3 21 45 116 140 109 144 0.84

3 7 0.0052 37 4.2 0.7 17 44 140 167 136 170 0.86

4 7 0.0035 25 4.8 0.6 17 45 168 196 163 199 0.86

5 7 0.0014 9.9 6.1 0.4 18 44 197 223 196 228 0.91

6 7 0.00065 4.7 7.1 0.1 21 44 228 251 224 256 0.89

7 7 0.0042 31 4.5 0.2 21 44 256 279 253 284 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	3.2e-06	0.023	14.5	0.1	6	48	70	112	65	115	0.88
2	7	0.0063	46	4.0	0.3	21	45	116	140	109	144	0.84
3	7	0.0052	37	4.2	0.7	17	44	140	167	136	170	0.86
4	7	0.0035	25	4.8	0.6	17	45	168	196	163	199	0.86
5	7	0.0014	9.9	6.1	0.4	18	44	197	223	196	228	0.91
6	7	0.00065	4.7	7.1	0.1	21	44	228	251	224	256	0.89
7	7	0.0042	31	4.5	0.2	21	44	256	279	253	284	0.84

Coding Sequence: ATGGCACAAACGATAGACGTGGGCTGCGTCAAGGAGGAGCACTGTGAGGCGATTTGCAATATGTTTAAAGCCCAGGATTGGCCACTGACCATGCGACACAGGGACCTGGGTCTGGTTAAGATCGAGCAGGACATGAGCTTTGTGTGGCAAAGCAGCCCCAATGTCACGTTGGATGGCAAGGACCGACAACCAGAGAAGCAGGCACAGAAAAAATTCCAGCACGGTGGCAAAACGCCGTACAGCGGGTCGGCCAGCGAGAAGCCTTTCAAGTGCGCACACTGCCCCAAGGACTTTGCCACCAGCAGCAATCTGAAGGTGCATCTGACGCGCACCCACTCCGGAGATCGCGAGCGCCCGTTTTTGTGCCCCAACTGCCCCAAGTCGTTTGCGACCAATGATAATCTGCAGAAGCACATACGCAGGCATTCGAGCGAGCGCAACCTCAACTGTCCACACTGCCCCAAGGCCTTTGCCACAAAGGATAATCTACAGAAGCACATACGCCGGCACTCGAGCGAACGCAACCTCATCTGTCCGCATTGTCCCAAGGCATTTGCCACCAACGACAATCTACAGAAGCATATACGCCGGCACTCGAGCGAGCGCACCTTAAATTGTCCACACTGCCCGAAGGCATTTGCCACCAATGATAATCTGCAGCGGCATATACGCGGTCATACGGGTGAGCGACCCTTCAAGTGTCCCTATTGCCCGAAACCCTTTGCCCAAAACAGAGATCTCAAAGCGCACATCCTAGAGCATACGGGCGAGAAGCCCTTCAAGTGTCCACACTGCCCCAAGGCGTGCGTCCGCAGCGAGGGCCTCAAGAAACACATACTGCGCCTGCACAAGGACATCGAACCCGAGCAACGACTGACGGCGACCAAGCAATGGCCAACGGGCGACCCAAACGGCAGAGTCTTTATGTACAAATACGATCTAACCAAACACACACGAATGCCCACCGGCGAGGCGTAA
Protein Sequence: MAQTIDVGCVKEEHCEAICNMFKAQDWPLTMRHRDLGLVKIEQDMSFVWQSSPNVTLDGKDRQPEKQAQKKFQHGGKTPYSGSASEKPFKCAHCPKDFATSSNLKVHLTRTHSGDRERPFLCPNCPKSFATNDNLQKHIRRHSSERNLNCPHCPKAFATKDNLQKHIRRHSSERNLICPHCPKAFATNDNLQKHIRRHSSERTLNCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHILRLHKDIEPEQRLTATKQWPTGDPNGRVFMYKYDLTKHTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2