Dame008645.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila americana
Gene Symbol
-
Assembly
GCA_018152915.1
Location
JAECXQ010000569.1:4431261-4433481[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 4.5e-06 0.00026 21.0 3.4 1 23 88 110 88 110 0.98
2 17 0.0084 0.49 10.7 3.1 1 23 116 138 116 138 0.96
3 17 0.00015 0.0089 16.2 1.6 1 23 144 166 144 166 0.98
4 17 1.9 1.1e+02 3.3 2.2 1 12 172 183 172 186 0.89
5 17 2.2e-05 0.0013 18.8 0.1 2 23 190 211 189 211 0.97
6 17 3.3e-05 0.002 18.2 5.8 1 23 217 239 217 239 0.97
7 17 0.00075 0.044 14.0 2.0 1 23 245 267 245 267 0.97
8 17 0.00061 0.036 14.3 0.4 1 23 276 298 276 298 0.95
9 17 0.00031 0.018 15.2 0.4 1 20 434 453 434 454 0.95
10 17 4e-08 2.3e-06 27.4 3.9 1 23 469 491 469 491 0.98
11 17 2.2e-07 1.3e-05 25.1 2.1 1 23 497 519 497 519 0.99
12 17 6.4e-06 0.00037 20.5 3.5 1 23 525 547 525 547 0.99
13 17 2.9e-07 1.7e-05 24.7 2.4 1 23 557 579 557 579 0.98
14 17 2.2e-06 0.00013 21.9 4.6 1 23 585 607 585 607 0.99
15 17 7.9e-07 4.6e-05 23.3 2.3 1 23 613 635 613 635 0.98
16 17 0.00013 0.0076 16.4 3.6 2 23 642 663 641 663 0.97
17 17 5.4e-06 0.00031 20.7 5.7 1 23 669 691 669 691 0.98

Sequence Information

Coding Sequence
ATGGACGTGAGCTGTGTGAAAATCAAGCAGGAGGAGCAAGAACAGGAGACGCTGTCAATGGATACGGTCTCGGAGGACGCCAGCTGTGCCCAGCTAAAAATTGAAAGCAATTTTACGGAGATGGACATAGGACCCATCAAAATAGACCCGGATGCGGCTGCAGTGTGTCAGGAACAGGCAGCTGCCGGCAACGCAAGGGATCGGCGAAAAAAGCAGAGACCTGCCGCAACACTGGAGGATTACAGACTGCCCAAGGGACCCCATCAGTGCCCGCACTGTCCACGGCACTTCGAAAGAAGCGACGAACTCACAATACACCTGCAGATCCACACAGATAAATTGCCCTACAAGTGCGTCTATTGTCCGAGCAGTTTTTCCCATAAATCGATTTACACCACGCACATGTACGGACATACTGGCAAATTTCCGCACCAGTGCCCGGACTGTCCGCAGGGTTTCCTGAAATACGGCGATCTCAAGAAGCATCGACGCACGCACATCGATAAAAATGCATTCAAATGTCCGCTGTGCCCCAGAAATTGCACACACACGGGCAAGGGTATACTGCAGTGCCCGCAGTGTCCGCGTGGCTTTACGAAGAGCTTCGAGCTGGAAATTCATCTGCAGATTCATAGCGATAAGCTGCCCTACAAGTGTCCACACTGCCCGAACAGCTTTGCACACAAATCGAACTTTAAAGCACATGTCTGTGAGCATACGGGCGAGTTTCCATTCAGATGCCGATACTGTCCGCGGGGCTTTATGAAGAGGAGCGATTTGCTGAACCACTCGTATACGCACAGCGAGCATACGGACGAGCTGCCATTCAGATGCCCATATTGCCCGCAGAGCTTTCTGACGGAAAACGATCTGCAGAAGCACTCAGATATTCATAGAGCTAAGATTTCGCAAAACTATCGCAACAAACTGGGCTCTAAATCTGGTTTAAAACGCCACAAAGACAATGCGCATAACGAAATCATAGACGTAAGCTGTATCAAAAAAGAACGGGCGGAGTCAAGTGAAACCCTTCCGAAAGAAGCCCAAGTCGAGGCCAAAGCTGATCCGTCTATCAGCCAAACAGTCGAAACGCCAGAGCTCATAGCTGCCGACCGCATAAAAGTGGAGCCCGGAACGGAGGATAGCGGTTCTACAGCGGACTACAGTGCCTTAGATAAGTCTGATAGTAAAAATGATTTGGCTGAGAGCAACATTGTGCTGGGCCCCATCAAAATAGAACCGGATGAGAGCAGGCCGCCGGAGGAACAGACTTTAGCAACCGTGCGCTCAAAGCGTTGCTTTAAATGCAAAGTTTGCAGCAAGGCGTTCACGGACATAAAAGAGCTGCGCCTGCACGAAAAATGCTACACACACTCAAGCAGGCAGACGGCAGGCAATCGGCCGTATAAATGCGAGCATTGCTCAAAGACTTTCACCCAGTCGTACAACCTGACGGTGCACATGCGCGGCCATACGGGTGAGCGGCCGTACAAATGCCCGCACTGCACGCGCACATTTATCCAGAGCTCGGGCCTGAAGATACACATACGACAACATTCCGGCGAACGGCCATATAAGTGCGCCCATTGTCCGCGCACATTTGCCAACAACTCGAATCGCAAGAAGCACCTACAGAGTCATGGCATGGAAGTTGCCAGCGATCTGCCGTACAGGTGTCCGCATTGTCCCAAAACCTTTGCACAAAACTCACATTTCATTGTGCACGTACGTGGACACACCGGCGAACGGCCCTATCAATGCACCTATTGCACCAAGGGCTTTAAGGTCAGCCACGATCTGAAGAAGCATCTGCGCAGCCACACGGGCGAGCGTCCGTATGTGTGTCCGCATTGTGCCAAGACCTTTGCGCAGAACTCGCATTTCAATGCCCATCTACGTGGCCATGCCAACGAACGACCACTGAAGTGCCCTCACTGTCCGCGCTCCTTTCTGAAAGCCTACAATCTCAAGGTGCATCTGTGCACCCACACTGGAGAGCGGCCGTACAAGTGTCCACACTGTCCGAAAACCTTTACACAAAACTCTTACTGCAAGGCGCATATGCGTGAGCATATGAAATGA
Protein Sequence
MDVSCVKIKQEEQEQETLSMDTVSEDASCAQLKIESNFTEMDIGPIKIDPDAAAVCQEQAAAGNARDRRKKQRPAATLEDYRLPKGPHQCPHCPRHFERSDELTIHLQIHTDKLPYKCVYCPSSFSHKSIYTTHMYGHTGKFPHQCPDCPQGFLKYGDLKKHRRTHIDKNAFKCPLCPRNCTHTGKGILQCPQCPRGFTKSFELEIHLQIHSDKLPYKCPHCPNSFAHKSNFKAHVCEHTGEFPFRCRYCPRGFMKRSDLLNHSYTHSEHTDELPFRCPYCPQSFLTENDLQKHSDIHRAKISQNYRNKLGSKSGLKRHKDNAHNEIIDVSCIKKERAESSETLPKEAQVEAKADPSISQTVETPELIAADRIKVEPGTEDSGSTADYSALDKSDSKNDLAESNIVLGPIKIEPDESRPPEEQTLATVRSKRCFKCKVCSKAFTDIKELRLHEKCYTHSSRQTAGNRPYKCEHCSKTFTQSYNLTVHMRGHTGERPYKCPHCTRTFIQSSGLKIHIRQHSGERPYKCAHCPRTFANNSNRKKHLQSHGMEVASDLPYRCPHCPKTFAQNSHFIVHVRGHTGERPYQCTYCTKGFKVSHDLKKHLRSHTGERPYVCPHCAKTFAQNSHFNAHLRGHANERPLKCPHCPRSFLKAYNLKVHLCTHTGERPYKCPHCPKTFTQNSYCKAHMREHMK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00551015;
90% Identity
iTF_00506249;
80% Identity
-