Basic Information

Insect: Drosophila ambigua
Gene Symbol: ken1
Assembly: GCA_018150905.1
Location: JAECWS010000002.1:17989973-17992157[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.00034 0.023 14.9 2.6 2 23 199 220 198 220 0.97

2 12 0.00065 0.044 14.0 0.2 1 23 226 251 226 251 0.93

3 12 0.051 3.4 8.1 0.1 3 23 260 283 258 283 0.92

4 12 4.9 3.3e+02 1.8 0.4 13 23 287 297 286 297 0.85

5 12 8.3e-06 0.00056 20.0 0.6 1 23 304 326 304 326 0.98

6 12 0.0021 0.14 12.4 0.2 1 23 332 354 332 354 0.98

7 12 0.044 3 8.3 2.0 1 23 360 383 360 383 0.97

8 12 0.0089 0.6 10.5 4.0 1 23 389 411 389 411 0.96

9 12 0.00075 0.051 13.8 2.9 2 23 418 439 417 439 0.96

10 12 9.6e-05 0.0065 16.6 1.2 3 23 529 550 527 550 0.95

11 12 0.0026 0.18 12.1 1.1 1 19 556 574 556 578 0.95

12 12 3.6e-06 0.00024 21.1 1.0 1 23 584 606 584 606 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.00034	0.023	14.9	2.6	2	23	199	220	198	220	0.97
2	12	0.00065	0.044	14.0	0.2	1	23	226	251	226	251	0.93
3	12	0.051	3.4	8.1	0.1	3	23	260	283	258	283	0.92
4	12	4.9	3.3e+02	1.8	0.4	13	23	287	297	286	297	0.85
5	12	8.3e-06	0.00056	20.0	0.6	1	23	304	326	304	326	0.98
6	12	0.0021	0.14	12.4	0.2	1	23	332	354	332	354	0.98
7	12	0.044	3	8.3	2.0	1	23	360	383	360	383	0.97
8	12	0.0089	0.6	10.5	4.0	1	23	389	411	389	411	0.96
9	12	0.00075	0.051	13.8	2.9	2	23	418	439	417	439	0.96
10	12	9.6e-05	0.0065	16.6	1.2	3	23	529	550	527	550	0.95
11	12	0.0026	0.18	12.1	1.1	1	19	556	574	556	578	0.95
12	12	3.6e-06	0.00024	21.1	1.0	1	23	584	606	584	606	0.98

Sequence Information

Coding Sequence: ATGGATATGGTTGCAAGCGAGCCATATCTCGTGCACTCAATATGCCGCCTCTGTCTGATGTACCTGGAGCAGAGTTCCGCCCACAATCTGTTTCTGGAGCCAGATCTGGCCAAAAAGCTAACGCTGTGCACCTCCCTCGATGTGGACCAACAGGATGGCTTTCCCCGGAGCATCTGCAACGGATGTTTTGAGAAATTGAACGACCTGCAGGAGTTTCAAAAACTATGCCTGGACTCGGTGAACCGATTCAAGGGTATGGTGGCCGCCAACAGAATCGTCACAGTTGAATTGTTGGAGCCGGTGGCCGAACAGCCAGCGGAGGTGATTGTGGGGCCGGAGGAGCATACCAGCTATGATCCGCTGCTAAATCACAAGCTGGAGATGATTGAGAACGAGGAGGAGGTCTTCAAGATGCTCGTGACGGTGGACAAAAGCGTTATCTCCGACTCTACATCCGAGGAGAACGAGGACGAGGATGGCTCCACCGATGACGAACTTCCATTGGCCCATCGTTTACTGGGTGAGGAGACGTCCAAGGAGCGAGCAAAGCGGAAAAGGATTCCGCCAGAGGAGCGTCGCCTCCGCCGTATCATCACCTGCACCATCTGCCAGCAAAAGTTCAAGAAGCAATCGAAATTCGACGAGCACATGAAGTACCACAACGACCTCCTGCCCTTCCAATGTACAGAGGAGACCTGCAAGAAAGGCTTCACCACAGCCGGTGCACTGCGTCTGCATGTGGACTATGCGCACACCAGGAAAGTCGATGAGATACCATGCAGCGTGGAGGGCTGCAAGCTGCTTTTTCCCCGCCTGCGGCTGCTCACCATTCACCTGAAGAAGGTTCACAACCAGACGCGGGTGGCACTCAAGAAGCACATGTACAAGCACACGGGCGAGGAGCTGCCGTACCCGTGCAACATCTGCGGCAAGGGATTCCACATCAACAGCGCTCTCAAGAACCATCTGCTGCGGCATGCGGGCATCAAGAACTACGTCTGCCCGTACTGTGGCGTGGGCAAGACGACGCGACAGGAATGGAGCAAGCACATGCTGACCCACACCCAGGAGAAGCAGTTCAAGTGCGCCACCTGCGACCATGCCACGCACACAAAGCGAGCGCTGGACAATCATGTGAAGATCGTTCACGAGAAGGTCCGTAACTTTGCCTGTCAGTACTGCGGGAAGACGTTCGGCAAGTCGCATGCCTGCAAAATCCATGAGATGACACACACGGGGGAGAAGCGGTGCGAGTGCAAGGTCTGTGGCAAGAAGTTCCTGTACACCGAAAGCCTCACAAAACACCTAAAGATACACGAGAAGAGTGTCGAGCGTGCCTTGGAGACGTATCGCCAGCGACAGGGAGAGACCAGCGCCGACCAGGATCAGGTCCAAGTGGATGCCAATCATCTGATGAAAGTCTGCGCCGAATCGGTGGCCACAATACCACGGGACCCGCGACGCGTGGAGCGCGTTGATATGGCCCAATTAGCGGGCACTGTTGTGAATCCCATACCCATCGTGTCGTTGCCCTCCAGTGCGCCGCCGCAGGCAAAGTTCGTTCAGAAGGAGGGCATGCATCTGTGCCCGGGCTGCAATCAGGGATTCAACAACCTGGGCAACATGAAGCGACACTACAAGAGCATCCACGAGAAGGTCAAAGACTTTGAGTGCCGCTTCTGTTCGCGTCGCTTCGCCAACTCGCAGTCGCTCAAGCAGCACGAATGGATACACACGGGCGAGAAGCCATACGCCTGCAAGACCTGCGGCACCCACTTCCGCCAGGAGGCGGCTCTCATACGCCACCAAAAGGTGCACGACGAAAAGCCACCCCGGCCAGCGAAACCGCCCAAGGAAATCACAGACAAGGCGCGCCAGAAGCTGCTGCAGAGATGCGAACGCAAGCGCAAGGTGGAGGCACTGCGTCAGGAGATTGCCCAGGCCGCCAAGGAGGAGCTGAAGGACTTGGAAAAGCACCGGGCCCTGGAGAAGGAGCAGAATACCTATGAAAAGTATCAGGCAGCGGCAGAGGCGGTGGAAAGCACCTCAACTTGA
Protein Sequence: MDMVASEPYLVHSICRLCLMYLEQSSAHNLFLEPDLAKKLTLCTSLDVDQQDGFPRSICNGCFEKLNDLQEFQKLCLDSVNRFKGMVAANRIVTVELLEPVAEQPAEVIVGPEEHTSYDPLLNHKLEMIENEEEVFKMLVTVDKSVISDSTSEENEDEDGSTDDELPLAHRLLGEETSKERAKRKRIPPEERRLRRIITCTICQQKFKKQSKFDEHMKYHNDLLPFQCTEETCKKGFTTAGALRLHVDYAHTRKVDEIPCSVEGCKLLFPRLRLLTIHLKKVHNQTRVALKKHMYKHTGEELPYPCNICGKGFHINSALKNHLLRHAGIKNYVCPYCGVGKTTRQEWSKHMLTHTQEKQFKCATCDHATHTKRALDNHVKIVHEKVRNFACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYTESLTKHLKIHEKSVERALETYRQRQGETSADQDQVQVDANHLMKVCAESVATIPRDPRRVERVDMAQLAGTVVNPIPIVSLPSSAPPQAKFVQKEGMHLCPGCNQGFNNLGNMKRHYKSIHEKVKDFECRFCSRRFANSQSLKQHEWIHTGEKPYACKTCGTHFRQEAALIRHQKVHDEKPPRPAKPPKEITDKARQKLLQRCERKRKVEALRQEIAQAAKEELKDLEKHRALEKEQNTYEKYQAAAEAVESTST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00536218;
90% Identity: iTF_00601216;
80% Identity: -