Basic Information

Gene Symbol
-
Assembly
GCA_001186385.1
Location
NW:256034-269597[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.1e-14 6.8e-11 41.1 0.0 9 72 154 222 150 225 0.95
2 2 0.033 2e+02 1.2 0.0 29 70 352 392 323 398 0.78

Sequence Information

Coding Sequence
ATGGATAAATCGGAGAGGAAGAAATCTGCtggtttaaaagaaaccaataaacttttaaaaccaGAACAACATTTTATTGGATTTGATATTGATGATGAACTTTTGATAATcattgaaaataagaaaaaatCATTAAAAATGGAACTTAGTAAAGAAACAACAGGTGAACCTGTGGAAGTAGAAGAGCCCTCCATTGTTAATAATAACCATGTTAATAAAAAGAAACCGTCTAAATCAAGTAtatcatCACCWGAACCTAATGATGTCAARAACAATCGTAGTAACAAGAGGCATAAGAAAGACAATTTACGCAGTGATGCTTTAGAATCTTCAGAGTTACAAGTTCTCCCTACTTTAGaaCTTAGTACTCCAACATTCAACCTCACCTCATCTAACGCTAGAGCACGTCGTAGTACAggtagaaaaataaatgttgatatcAGTGATGCTATTTTCAAACTTCCATTTGAGCATGgatGGAAACGAGAATTAGTTTACAGAACATCGGGTGAATCTACAGTTCTTAATCGARCAAATAGAAGTGGTGATGTATACTATTATTCTCCAAGTAACCGAAAACTTAGATCATTACGAGAAATTCAAGAACAATTGGACATCTCGCCTGATAAGGATCTAACTATAgaaagttttacatttttaaagcaACCAATTGGCTTGAATGACCGATCAAAAGAACTGATCAGAGATGCTAATTCTAAATTATCTAAAgaAGATTCATTTGTTGGTCTTGCTGTTAGacctaaaaaatctaaaacaccTGTACAACGACCACCATTTGATTATGAATTGTCAGAAGATGAAAACAACAAGTCTTCAAGTAAAATGAaggttgtttttaaaaatgctaaGAGCTCCTCAAGATCAAGATCTAAAAAagGTAATTCAGAATCATTGAACGCCTCTTCATCTACACCTGAATACATATCTGAAGACTGGCAAGCTATTAAATCTAGTGCATCACCTAAAGTTTCTTCTCCGAAACTTGAGAATATTGATATAGATAACACAGTTAATAAAAGACGGTTGTCAACATCAGATGGTGAAGTTATTATGCAAACACCTTGTGGGATACGGTGCCCAAATAGTGATGAACCTGCCACTTTGATGTGTGCTCAATGTTTGGTCTACTATCATCCAGCATGTGTCAATTTAaatgctaatttaaaaattgttggttATGTCTGTATAaactgTCGATCTACTGTGCGACAAAGAAATAGACGTGTACAGTCCTCTCATACAGTGATTATTGGTGCTTCTGAACCAGAACAACTGCGTGTTGAACCAATTCGTATACGACAACTTCATCAAGGGTCGGAATCATCAGACAcacctaattttattattgatagaaCACCAATTTCTAAAACTGAAGAAACACATAATGAAATTGATGAAAATAGTGATGATAATGACtctgatataataaatacagttatTTGTCAAGGAAATGAATATAAAACTACAATGGTTGATGGTAATTTCCATGAACAATATGTTTATGAAATGAAACAAACACGAGGACCTAGTTTGATGACATGTGTTATTCAAGAACCTAAAAATTTGGATGAGAATTCTGAAATGAATGGTTCATTAAGAGAAGTTGTAACACCTTTTGCATCCATGCAATCATTCAATTACATGGTTAAAGCATTAAGACATGTTTTTAAACATCTGAAAACACATGAGCTTTTATCAGCTTCTAGAGTATGTACTGCCTGGCATATAATAGCAATGAATAAGTTCTTGtggcAGACTGTTCGCTTAAAAAATTCTATGGTTTATGACTGGGAAAGGTTTGTAGACTCTATTGATCAACAAAGAACTGAAACATTAGATACTAGGCGTATGTTGATACCTGTTAAAGTTGAAGAATTCGAAAATTTTTGGTTGCGTTTTTCTATAGCTATGAAAAGAGCTCAAAAGTTGAAATTCATTGAATTATATAGATGTCCTACCCATGTTGTTGAAGATATTATTTACTCATTACCTCAAATTGAAATACTTAATGCTAgttcaataaaaaatccaAATGTTACAAAAGARGCAAAAAATGTCAATGATTTTATGCTcctaaacttaaattatttggGACAAATGACAAAGCTCACAGAGTTAAGACTAAAAGGATTAACTGGAATAAAATTGACGTCCTTGCCatcatttgaaaatttagtaaatttgaataaatttTCATTAACCTCTATTAAATCATTTCCAAAAGACATCTGTCAGAGTTTGGATACTATTACTGATAATATTGAGTTTTTGGAAATTGGTGACTGTGATTGCTTATCAAAGGATTTTGCCGCATCACTAAAAAGATTTGTCAATTTGAAATCATTGAGATTAGAAAATTGCTGTGGTAGATGGGAACAATATGCACAAGAAGTTTTTACTGTCATTAGAGGACTTGAAAAGCTCAAGATTTTGGAATTGATAAATATAGAATTCAGTAATTGTGTTGAAGATGAATTAGAAAAATGTGATGGTATTAAAGCTTTACTGATAATTCCTGCTTATGTGAGCCAatccgCTACTACTAACTGTCACCTAATTGACTGTCTCAAGATACTCTCTAAGACATTAACACACTTGGTTTGGGGATTGACTCATGAGTTACTCCGTGTTACAGACTTGTTTATAACTCAATATCAACAAAACCAGCATACTATTGgttataatttagaattatcTCATACCAAAGAAACAAccaacaatatacctatattgaggACAAGAAAGCCCAGGCAGCGACCAGGAGATGAGCCTGCTCCCGAAAAGGAAAAAGAAAAAGACAAGTCAGATAATGTTGATATACTTTCAGTTCCTGCACTAGAAAAATTGTTAGATACAATGATGCCTGATGCTAAGACTAAAGTAATTAAGGTTCCCTTTTCTGGAACTGTTAGAGTTTATTTAAGTGAACAGTTTAATGATCTTTGA
Protein Sequence
MDKSERKKSAGLKETNKLLKPEQHFIGFDIDDELLIIIENKKKSLKMELSKETTGEPVEVEEPSIVNNNHVNKKKPSKSSISSPEPNDVKNNRSNKRHKKDNLRSDALESSELQVLPTLELSTPTFNLTSSNARARRSTGRKINVDISDAIFKLPFEHGWKRELVYRTSGESTVLNRXNRSGDVYYYSPSNRKLRSLREIQEQLDISPDKDLTIESFTFLKQPIGLNDRSKELIRDANSKLSKEDSFVGLAVRPKKSKTPVQRPPFDYELSEDENNKSSSKMKVVFKNAKSSSRSRSKKGNSESLNASSSTPEYISEDWQAIKSSASPKVSSPKLENIDIDNTVNKRRLSTSDGEVIMQTPCGIRCPNSDEPATLMCAQCLVYYHPACVNLNANLKIVGYVCINCRSTVRQRNRRVQSSHTVIIGASEPEQLRVEPIRIRQLHQGSESSDTPNFIIDRTPISKTEETHNEIDENSDDNDSDIINTVICQGNEYKTTMVDGNFHEQYVYEMKQTRGPSLMTCVIQEPKNLDENSEMNGSLREVVTPFASMQSFNYMVKALRHVFKHLKTHELLSASRVCTAWHIIAMNKFLWQTVRLKNSMVYDWERFVDSIDQQRTETLDTRRMLIPVKVEEFENFWLRFSIAMKRAQKLKFIELYRCPTHVVEDIIYSLPQIEILNASSIKNPNVTKEAKNVNDFMLLNLNYLGQMTKLTELRLKGLTGIKLTSLPSFENLVNLNKFSLTSIKSFPKDICQSLDTITDNIEFLEIGDCDCLSKDFAASLKRFVNLKSLRLENCCGRWEQYAQEVFTVIRGLEKLKILELINIEFSNCVEDELEKCDGIKALLIIPAYVSQSATTNCHLIDCLKILSKTLTHLVWGLTHELLRVTDLFITQYQQNQHTIGYNLELSHTKETTNNIPILRTRKPRQRPGDEPAPEKEKEKDKSDNVDILSVPALEKLLDTMMPDAKTKVIKVPFSGTVRVYLSEQFNDL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00940496;
90% Identity
iTF_01032891;
80% Identity
-