Dmen004534.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Diarsia mendica
Gene Symbol
MBD-R2
Assembly
GCA_949316265.1
Location
OX438888.1:8416972-8429285[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.7e-15 4.8e-11 43.7 0.0 5 58 755 808 751 873 0.84

Sequence Information

Coding Sequence
ATGGCTGTTAAAAAGTGTTGCATTGACAACTGTAAGTCATGTTCTACAAGAAAGGAGGACAAAGGTGTAACATACCACAAGTTCCCAAAAGATGTTGCAATACATAACCTTTGGACAAATGTAACACATAACAAACACATAGACACAGACTTGTCCCAGTTTGTGTGTTCACGACATTTCCGTAAAAATGATTTTGAAACTTTCAAGGACTctaaattcaaattgaaaacagACGCAATCCCATCAATATTTCCATGGGATTCAGACACTGACGAAGATATGGAAGACATAATTGCCCCAGTGGAAGGTTTCAGCAAAGATTGTGAAATTGAGAATGTAGATGCTATAAAGAAGTTTATTGAAGCTCAGGAGAAAGAGATACAAGACCAGAAAGAAGCAGATATTCAGAATACAAAAAAACGTAATGGCTCTGACAATGAAGACAGTAAAACGAGTCAGGAAGAGACACTTTGTGTGGCCAGCAGCGTAATAGATATGATTCTCGATAAGTCTGAGATAGAGATTGCTAAGAAGAAAGATGTTGTTAGTAAGGAGTCTTTTAGTCCTATGGAATTGAAAGGAAACACCAGTATGGCACTGTCTGTTGGCTCTAAAGTCGAGGTTAAAGACTTCGAAGAAGAATGGCACTCTGCAGAAATTATAGAAGTTGACTATGAAGATATGGAAGTGCTTGTGCATTATATTGATACAAAAATACATGACGAATGGTTAAGCGTGGGCAGCCCTCGTTTACGGCCGGCCATTTCGTCTACTGCCAGTAGTACGACTACATCCACGGTGAAGCCGGGCCCTAGTTCCGAGGAGAGCATCACTGATACTATTCCTATAGCCAATCTGAAAGAAGAACCTAAAGATGTAAAGGTGGAAGAGAAATGTAAGCTGAGCTATGCAACGGGCGAGCGATGCCTCGCGAGGTGGCGCGATAACAGACGCTTTATAGCCACTATTCTCAGGGATTTGGGGGATGGCAATTACGAGATAGTATTCGACGACGGGTGTCATTGGACGTGTAACGCAACTAGACTGCACAAACTGCGTACAAAATCAGGCGAATTAGGCGCGACGTCGGCCCCCCTGACGTACGGGTCGGGACCTAGCAACACGACcccacaaacaaacacacagtTCCCCTCACCAGCTTTCCACACACACCTCTTCGACCCGACGCGAGACTACTTAGGATCCAAAAGCGAACGCCGCGAAATGAAACGTAAACTTAACATTAAGGAAATATTCAACATAGGACAGAAGAAGTCCCGTAAGCAGAAGATTGAAACGACCCTGAAGACAGAGCCCAGAAAACCAAGGATTCTGAAGACGAGAAGAGAGAAGGTGGTCAAGTTGAAGCTTGCGAGTGAAGTGAAGACTGAGATCAAGACTGAAATGCCTGCCTTAGATGCTGTAGCTTCGATAATTGGAACTGTTAACCAAGAGGAACCAGCACCTCTGGAAGTGAAGGAAGAAGTCGAAGCAGAAGAAGTGCATCAAGACATAAAGAAAGAAGTCCATCAAGATATAAAAGACGAAGACCATCAAGATATAAAGGAGGAAGTTCAACAGGACATAAAGGAGGAAGTTGAACAAGAAATCTCTGACGTCAATGATGAAAAAGCGACTTTGAAAGAAGAACTTCGTATTTCAATAGATAATGAGGACCTAATTCAATTGGCAGACTTGAGAGGTGATCTGGACCCGGTTGAAGAGGAAGTGAAACTCGAACAGTTCGAGAAAACAGACGACAGTAGACACGAGGAAGTCATTGACAGAATTAAAGAGGCCATCAACAAACTGGAAGATGGTCTGCACAACGAAAATATCGGCTCACCCATGCTGGTGCCGAAGGAAGAAATAATAACGACTCCGGAAGTAATCCCTGAGGTACCAGTAGAAGATAAAGAAGAGTTAGAACATTTTGTAGAAGTAAAGGACAAAAGGAAAAAGTTGCAAAAGATAAAGAAGGGTAAGAAGCTGCGGATGTTGCGGGAGAAGAAGGCGAAGATGCAAGCGGAGAAGGTGCAGAATGAGCTGAACAAGATGAGGAAGCAGATGGAGGAAATGCGGCAGCTGATGCTGAAGGGACAGGAGATGGGCAAGGGTGCTTCGATGCCGGAGAGCTTCCTTCTGCCGGGCGAGTGGTGTTGTCGCTGGTTGAATGGCCAGCCCGTGGGCGCTGTCAGCGAGATCGAGTGCGAGCTGCGGGGAGAGCCAGGGGGACCGGTGCCGCTGCCTAGGAGGAGTGTGCAGGTCGAAGACAAAAGGCTACCAGATGGCTGGACCAAACACATGGTTCGAAGGAGCTTGGGACATTCTGCGGGCAAGTGGGACGTCGTGTTAGTCAGCCCTGACAACCGAAGGTTCCACACTAAGCACGAAATGCGTCTATACTTGGAGAACAAACCAGAACTTATCGAGCAAGGCTACGAACACCCGCTCACAGACTTCGGCGTACACCTGAAGATGGCGCGGCGTCTGGGCTGGATCGAGAACACGGCCGACGGAGCCCCGGGCGCCGCCCCGCTCGCGCCGGGCACGCTCAGCAGCACCTCGCCACTCGTCAAGCGAAAGAAGCTGAGTCTCAAGAAGGTCAGAAAGGAAAGGGAGAGAAAAGGACAGAAGAGAGTACCTAAGATAACTATTAAGATGAAAGTCCCAAAAGAACCACAGTACGTGCCACCAGAAGACTCCATGCCGTCTCCAAGTGCGGACAGTTTTCATGCCGAAGTTATCGATGTGCCGCCATTAGAAGATGGATATGTGTATGTGGGCGCACTTAAAGTACAAATAATCGATAACCTTCTTCGATGCCCAGCCGAAGGTTGCTTCAAAAACTTCAGAAACAACACGCTACTACAGATGCACATAAATCACTACCACACTGATCTCAGACGGATGATGGGAGCGACCCCCAAGGTGCTGGATCTAGCCTACGCTAGGACTCTGCCAGTAGGGATAGAAACTCCTCGCTCTAAAGAAGACAGTAAGTTCATCAAGGTTAAAATTCCTCGACTACCAAAACGTGAAGAGCCCAAACCACCTGTAAAAGAGCTAGAAGTAAAAGATATTGAAACTGAATTACAAGTGGACACCAGATCCATTACGCCTGTTAGAGATGGCGTCAGTATACGTGTTCCCAGGAGTCAGGACTCGCCCAAACTGCGGCAGGCTCTCATCAACAAGCCTGTGAAGAAACGGCCAAGAGTGCTGTTACCTGTTAGAAGACCGGAACCTGAGCCATTCCTACCAGACCCTATGAACGAAGACATAGATGTGGAGGAGACAGACACCATCGAGCCAATCATTGAAATACCACCTCTAGACATGCCTTTGGACTTCGAGAGTGCCATATCAACGCATACAGTTAGCAAACCTATGTTTGAGAAGAAACGTAAAAGCGAGAAGCGACGTAAAACGTTCGCGGTGGCTGCTAAAAGGCCAGTTAGTGAGGAAGAGGACTGGTACGGGGTCAACTCGGACTTTGAAACCCGGTCTAGCTTCCCCAGGTCTGAAACACCGGACTCGAAGGTTGATTCCAAATTGGTGGCCGCGTCCTCTGAGTCTAATGAAGAGCACAAGGATGTTGCTAATATGTACATGTTTAATGAAAATGGCGAGAGGATAAAGATAGTGCATATGAAACGCGAAGAGATCATCAACTGCCACTGCGGGTTCCGTGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAACACGCCATGTGCCACAACATACAGCGCGAGTGTGACGTAAGTGTTCCGTGA
Protein Sequence
MAVKKCCIDNCKSCSTRKEDKGVTYHKFPKDVAIHNLWTNVTHNKHIDTDLSQFVCSRHFRKNDFETFKDSKFKLKTDAIPSIFPWDSDTDEDMEDIIAPVEGFSKDCEIENVDAIKKFIEAQEKEIQDQKEADIQNTKKRNGSDNEDSKTSQEETLCVASSVIDMILDKSEIEIAKKKDVVSKESFSPMELKGNTSMALSVGSKVEVKDFEEEWHSAEIIEVDYEDMEVLVHYIDTKIHDEWLSVGSPRLRPAISSTASSTTTSTVKPGPSSEESITDTIPIANLKEEPKDVKVEEKCKLSYATGERCLARWRDNRRFIATILRDLGDGNYEIVFDDGCHWTCNATRLHKLRTKSGELGATSAPLTYGSGPSNTTPQTNTQFPSPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKSRKQKIETTLKTEPRKPRILKTRREKVVKLKLASEVKTEIKTEMPALDAVASIIGTVNQEEPAPLEVKEEVEAEEVHQDIKKEVHQDIKDEDHQDIKEEVQQDIKEEVEQEISDVNDEKATLKEELRISIDNEDLIQLADLRGDLDPVEEEVKLEQFEKTDDSRHEEVIDRIKEAINKLEDGLHNENIGSPMLVPKEEIITTPEVIPEVPVEDKEELEHFVEVKDKRKKLQKIKKGKKLRMLREKKAKMQAEKVQNELNKMRKQMEEMRQLMLKGQEMGKGASMPESFLLPGEWCCRWLNGQPVGAVSEIECELRGEPGGPVPLPRRSVQVEDKRLPDGWTKHMVRRSLGHSAGKWDVVLVSPDNRRFHTKHEMRLYLENKPELIEQGYEHPLTDFGVHLKMARRLGWIENTADGAPGAAPLAPGTLSSTSPLVKRKKLSLKKVRKERERKGQKRVPKITIKMKVPKEPQYVPPEDSMPSPSADSFHAEVIDVPPLEDGYVYVGALKVQIIDNLLRCPAEGCFKNFRNNTLLQMHINHYHTDLRRMMGATPKVLDLAYARTLPVGIETPRSKEDSKFIKVKIPRLPKREEPKPPVKELEVKDIETELQVDTRSITPVRDGVSIRVPRSQDSPKLRQALINKPVKKRPRVLLPVRRPEPEPFLPDPMNEDIDVEETDTIEPIIEIPPLDMPLDFESAISTHTVSKPMFEKKRKSEKRRKTFAVAAKRPVSEEEDWYGVNSDFETRSSFPRSETPDSKVDSKLVAASSESNEEHKDVANMYMFNENGERIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHAMCHNIQRECDVSVP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00445208;
90% Identity
iTF_00447234; iTF_00446233; iTF_00446166; iTF_00445248; iTF_00445208;
80% Identity
iTF_00447234;