Basic Information

Insect: Diarsia brunnea
Gene Symbol: MBD-R2
Assembly: GCA_949774965.1
Location: OX458998.1:16339552-16350418[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.5e-14 1.9e-10 41.2 0.0 5 59 757 815 753 871 0.84

2 2 5.6 2.3e+04 -3.9 0.0 13 33 1165 1185 1162 1188 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.5e-14	1.9e-10	41.2	0.0	5	59	757	815	753	871	0.84
2	2	5.6	2.3e+04	-3.9	0.0	13	33	1165	1185	1162	1188	0.84

Sequence Information

Coding Sequence: ATGGCTGTTAAAAAATGTTGCATTGACAACTGTAAGTCATGTTCTACAAGAAAGGAGGACAAAGGTGTAACATACCACAAGTTCCCAAAAGATGTTGCAATACGTAACCTTTGGATAAATGTAACACATAACAAACACACAGCCACAGACTTGTCCCAGTTTGTGTGCTCACGGCATTTCCGTAAAAATGATTTTGAAACTTTCAAGGACtctaaattcaaattgaaaacaGACGCAATCCCATCAATATTTCCATGGGATTCTGACACTGACGAAGATATGGAAGACATAATTGCCCCAGTGGAAGGTTTTAGCAAAGATTGCGAAGTTGAGAATGTAGATGCTATAAAGAAGTTTATTGAAGCTCAGGAGAAAGAGATACAAGACCAGAAAGAAGCAGATAATAATaagattacaaaaaaacttaatGGCTCtgacaatgaagacaataaatCGAGTCAGGAAGAGACACTTTGTGTGGCCAGCAGTGTAATAGATATGATTCTCGACAAGTCTGAGATAGAGATTGCTAAGAAGAAAGATGTTGTTAGTAAGGACTCTTATAGTCCTATGGAATTGAAagGAAACACCAGTATGGCACTGTCTGTTGGCTCTAAGGTCGAGGTTAAAGACTTCGAAGAAGAATGGCACTCTGCAGAAATTATAGAAGTTGACTATGAAGATATGGAGGTGCTTGTGCATTATAGTGATCCAAAAATaCATGACGAATGGATAAGCGTGGGAAGCACTCGTTTACGGCCGGCCATTCTGTCTAGTGCCAGTAGTACGACTACATCCACGGTGAAGCCGGGCCCTAGTTCCGAAGAGAGTATCACTGATACTATTCCTATAGCCAATCTGAAAGAAGAACCTAAAGATGTGAAGGTGGAAGAGAAATGTAAGCTGAGCTATGTAACGGGCGAGCGGTGCCTTGCGAGGTGGCGCGATAACAGACGCTTTATAGCCACTATTCTCAGGGATTTGGGGGATGGCAATTTCGAGATCGTATTCGACGACGGTTGCCATTGGACATGTAACGTAACTAGACTCCACAAACTGCGTACAAAATCAGGCGAATTAGGCGCGACGTCGGCCCCCCTCACGTACGGGTCGGGACCTAGCAACACGACcccacaaacaaacacacagttCCCTTCACCAGCTTTCCACACTCACCTCTTCGACCCGACGCGAGACTACTTAGGATCCAAAAGCGAACGCCGCGAAATGAAACGTAAACTTAACATCAAAGAAATATTCAACATAGGACAGAAGAAGTCCCGTAAGCAGAAGATTGAAACGACCCTGAAGACAGAGCCCAGAAAACCAAGGATTCTGAAGAGAAGAGAGAAGGTGGTCAAGTTGAAGCTTGCGAGTGAAGTGAAGACTGAGATGAAGACTGATATGCCTGCCTTAGATGCTGTAGCTTCGATCATTGGAACTGTTAATCAAGAGGAACCAGCACCTCTGGAAGTGAAGGAAGAAGAGAAAGCAGAAGAAGTCCATCAAGACATAAAAAAAGAAGTCCATCCAGAAATAAAGGACGAAGACCATCAAGATATAAAGGAGGCAGTTCAACAAGACATAAAGGAGAAAGTTGAACTAGAAATATCTGACGTCAATGATGAAAAAGCGACTTTGAAAGAACCTGAAGAACTTCGTATTTCAATAGATAATGAGGACCTAATTCAATTGGCAGACTTGAGAGGTGATTTGGATCCGGTTGAAGAGGAAGTGAAACTCGAACAGTTCGAGAAAACAGACGACAGTAGACACGAGGAAGTCATTGACAGAATAAAAGAGGCCATCAACAAACTAGAAGATGGTCTGCACAACGAAAATATCGGCTCACCCATGCTGGTATCGAAGGAAGAAATACTAACTGCTCCGGAAGTACACCCTGAGGTACCAGTAGAAGATAAAGAAGAGTTAGAACATTTCGTAGAAGTGAAAGAGAAAAGGAAGAAGTTGCAAAAGATAAAGAAGGGTAAGAAGTTGCGGATGTTGCGGGAGAAGAAGGCGAAGATGCAAGCGGAGAAGGTGCAAAATGAGCTGGACAAGATGAGGAAGCAGATGGAGGAAATGCGGCAGCAGATGCTGAAGGGGCAGGAACTGGGCAAGGTTGCTTCGATGCCGGAGAGCTTCCTTCTGCCGGGCGAGTGGTGTTGCCGCTGGGTCAATGGCCAGCCCGTGGGCGCCGTCAGCGAGATCGAGTGCGAGCTGCGAGGAGAGCCAGGGGGACAAGTGCCGCTGCCTAGGAGGAGTGTGCAGGTCGAAGACAACAGGTTACCTGATGGCTGGACCAAACACATGGTTCGAAGGAGCTTAGGTCATTCTGCGGGCAAGTGGGATGTCGTGTTAGTCGGCCCCAATAACCGAAGGTTCCACACTAAGCACGAAATGCGTCTATTCTTGGAGAACAAACCAGAACTTATCGAGCAAGGCTACGAACACGCGCTCACAGACTTCGGCGTGCACATGAAGATGGCGCGGCGTCTCGGCTGGATCACGAACACGCCCGACGGAGCCGCCCCGCTCGCGCCGGGCACGCTCAGCAGCACCTCGCCGCTCGTCAAGCGAAAGAAGCTGAGTCTCAAGAAGAACAGAAAGGAAAGGGAGAGAAAAGAACAGAAGAGGGTACCTAAGATAACTATTAAGATGAAGATCCCGAAAGATTACGTGCCACCAGAAGACTCGATGCCGTCTCCAAGTGCTTCAAGCGTCACTGACAGTATTCATGCTGAAGTTATCGATGTGCCACCATTAGAAGATGGATATGTGTATGTGGGCGCACTTAAAGTACAAATAATCGATAACCTTCTTCGATGCCCAGCCGAAGGTTGCTTCAAGAACTTCAGAAACAACACGCTACTACAGATGCACATAAATCACTACCACAGTGACCTCAGACAGATGATGGGAGCGACCCCCAAGGTGCTGGATCTAGCATACGCTAGGACTCTGCCAGTAGGGATGGAAACTCCTCGCTCTAAAGAAGACAGTAAGATCATCAAGGTTAAAATTCCTCGACCACCAAAACGTGAAGATCCCAAACCACCTGTAAAAGAACCAGAAGTGGAAGATATTGAAACTGAATTACAAGTGGACACCAGATCCATTACACCTGTTAGAGATGACGTCGGTATACCTGTTCCCAGGAGTCAGGACTCGCCCAAACTGCGGCAGGCTCTTATCAACAAGCCTGTGAAGAAACGACCAAGAGTCCTCTTACCTGTTAGAAGACCGGAACCCGAGCCGTTCATACCAGACCCTATGAACGAAGACATAGATGTGGAGGAGACAGACACCATCGAGCCCATCATTGAAATACCGCCTTTGGACATGGCTTTGGACTTCGAGAGTGCCATATCAACGCATACAGTTAGCAAACCTCTGTTTGAGAAGAAACGTAAAAGCCAGAAGCGACGTAAAACCTTCGCGGTTGCTGCTAAAAGGCCAGTTAGTGAAGAAGAGGACTGGTACGGGGTCAACTCGGACTTTGAAACCCGGTCTAGCTTCCCCAGGTCTGGAACACCGGACTCGAAGGTTGATACCAAATTGGCGGCCGCGTCTTCAGAGTCTAATGAGGAGCACAAAGATGTTGCTAATATGTACATGTTTAATGAAAATGGCGAGCGGATAAAGATAGTGCACATGAAACGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGTGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAACACGCCATGTGCCACAACATACAGCGCGAGTGTGACGTGCCAGAAAAATACACATGCAGCATTTGCCTGAACCCTCGTCGCGGTCGTCGGTCGCAGCGGTTCCTGCATGACCAGGATCGCATGTACGAGGGTCTGCTGCCGAACAGCAAGCCCTGCGAGGTGCTGCGCCGCTCGCACGAGCTGACCGGGAACCTGCTGAGGATCCAGGATGCTATCCATGCGCTCAAAGTCAAGTGTTATGTGGCTAGCAAAAAAGACCACCCAAAGCTGTACCTGTGGGCCAAAGACTGGGAACAGGTAGAGATCCAGAACACGCAGGAGCAGTTGAATTCGGACTACTCTGACCTGAACATCATGATCAACATGGACAAGGAGAACCAGCCTCTCCGCCCAGATGACGTGAGAGACTTGCCGATGGACATTCGCACTCCTACCTTTGACGAACAACAGGAACATGAGAGGTACACACAAAGGGAGGCTCCGCTGGGTTCTCAGTCCCTCCTGAGTGGTCTGCTGTCAAGTCCCGGTGGGGCGTCACTGGACCTGCCTATCAGCACGTCTGAGTTGGAACGATTTGCCAAGTCTGTACAAGAACAAGAACCCCAGCACACCGTGATAGCGGCCCCGCAGCCCGAGGCTCCCATAGAGAACGCGGCGTGTCGCCGGCAGCTGCTGAAGCACGTGCAGCGTTGCCAGGCGCTCATCGATGCCAGGCTTGACTCCATCGAGGCACAAGTTGCAGAACTAGAATCTCAGGATCCATCGTTAGAGGACGACGAGACAGCGGACTATTTCCCGCGCACCAAACAGACTGTAGAGATGCTGTTACGAGATCTCGAAACCATGGAGGAGCTGGGATCCATCACTTAA
Protein Sequence: MAVKKCCIDNCKSCSTRKEDKGVTYHKFPKDVAIRNLWINVTHNKHTATDLSQFVCSRHFRKNDFETFKDSKFKLKTDAIPSIFPWDSDTDEDMEDIIAPVEGFSKDCEVENVDAIKKFIEAQEKEIQDQKEADNNKITKKLNGSDNEDNKSSQEETLCVASSVIDMILDKSEIEIAKKKDVVSKDSYSPMELKGNTSMALSVGSKVEVKDFEEEWHSAEIIEVDYEDMEVLVHYSDPKIHDEWISVGSTRLRPAILSSASSTTTSTVKPGPSSEESITDTIPIANLKEEPKDVKVEEKCKLSYVTGERCLARWRDNRRFIATILRDLGDGNFEIVFDDGCHWTCNVTRLHKLRTKSGELGATSAPLTYGSGPSNTTPQTNTQFPSPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKSRKQKIETTLKTEPRKPRILKRREKVVKLKLASEVKTEMKTDMPALDAVASIIGTVNQEEPAPLEVKEEEKAEEVHQDIKKEVHPEIKDEDHQDIKEAVQQDIKEKVELEISDVNDEKATLKEPEELRISIDNEDLIQLADLRGDLDPVEEEVKLEQFEKTDDSRHEEVIDRIKEAINKLEDGLHNENIGSPMLVSKEEILTAPEVHPEVPVEDKEELEHFVEVKEKRKKLQKIKKGKKLRMLREKKAKMQAEKVQNELDKMRKQMEEMRQQMLKGQELGKVASMPESFLLPGEWCCRWVNGQPVGAVSEIECELRGEPGGQVPLPRRSVQVEDNRLPDGWTKHMVRRSLGHSAGKWDVVLVGPNNRRFHTKHEMRLFLENKPELIEQGYEHALTDFGVHMKMARRLGWITNTPDGAAPLAPGTLSSTSPLVKRKKLSLKKNRKERERKEQKRVPKITIKMKIPKDYVPPEDSMPSPSASSVTDSIHAEVIDVPPLEDGYVYVGALKVQIIDNLLRCPAEGCFKNFRNNTLLQMHINHYHSDLRQMMGATPKVLDLAYARTLPVGMETPRSKEDSKIIKVKIPRPPKREDPKPPVKEPEVEDIETELQVDTRSITPVRDDVGIPVPRSQDSPKLRQALINKPVKKRPRVLLPVRRPEPEPFIPDPMNEDIDVEETDTIEPIIEIPPLDMALDFESAISTHTVSKPLFEKKRKSQKRRKTFAVAAKRPVSEEEDWYGVNSDFETRSSFPRSGTPDSKVDTKLAAASSESNEEHKDVANMYMFNENGERIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHAMCHNIQRECDVPEKYTCSICLNPRRGRRSQRFLHDQDRMYEGLLPNSKPCEVLRRSHELTGNLLRIQDAIHALKVKCYVASKKDHPKLYLWAKDWEQVEIQNTQEQLNSDYSDLNIMINMDKENQPLRPDDVRDLPMDIRTPTFDEQQEHERYTQREAPLGSQSLLSGLLSSPGGASLDLPISTSELERFAKSVQEQEPQHTVIAAPQPEAPIENAACRRQLLKHVQRCQALIDARLDSIEAQVAELESQDPSLEDDETADYFPRTKQTVEMLLRDLETMEELGSIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00445248; iTF_00711969; iTF_00711888; iTF_01063786; iTF_01063836; iTF_01064688; iTF_01064741; iTF_00685465; iTF_00685520; iTF_00928729; iTF_01061915; iTF_01061967; iTF_01533128; iTF_01533074; iTF_01534856; iTF_01534924; iTF_01532116; iTF_01532039; iTF_00446166; iTF_00446233; iTF_00447234; iTF_00447166;
90% Identity: iTF_00447166;
80% Identity: iTF_00445248;