Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7.7e-23 6.7e-19 68.3 0.1 1 65 53 119 53 119 0.95

2 3 2 1.7e+04 -3.5 0.0 11 29 125 142 124 143 0.67

3 3 4.2e-17 3.7e-13 49.9 0.1 1 64 154 244 154 245 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7.7e-23	6.7e-19	68.3	0.1	1	65	53	119	53	119	0.95
2	3	2	1.7e+04	-3.5	0.0	11	29	125	142	124	143	0.67
3	3	4.2e-17	3.7e-13	49.9	0.1	1	64	154	244	154	245	0.90

Coding Sequence: ATGTTTGAAGATGATAACATTACATGTACTCCTAAACGATACGTTCTCACAGAGGTTACCAACTCGTCCAGTTATGTGTCTCCAACAGCTAACCTCAAGCTACTAACTAATGTCGCGTTGCATTACCCTACACCTCCGCCTAGTGCAGTGCACCGAAAGGAAAAATCATTGCAAATATTGTGTGACcggtTCCTTGATTTATATCCATTACATAGGAATGGTACTGTGGAAATACAATTGGATATTACTGCAGCCCGGTTAGGTGTAGAGAAGCGACGAATGTATGACATAATTAATATACTGGAAGCAATGCAATGTGCAGTTCACAAAAAGAAGAACACATACCTTTGGCATGGTGGGTCGAGGCTTAATTCCTTCTTGAAAATGTTGAAGAAACAAGGAGAAGCACTGAGATTATCTGAAGCATTGCGTGGTAGGGCTCCTAAACCACCAGCCCCTAAGCATAAAACCCTTGGGGTCCTAGCTCAAAGGTTTCTAATGCTGTTTTTAGTTGAGCCACCAAACACTCTGATTAACCTGGAGATGGCTGTTAGAGTCCTAATAgatacatcaaacaaaaacaagACTAATCTTTCCCCTGAGCAACAGGATCGGCAGCACAAGTCCAAAGTGAGACGCCTTTATGATATTgccaatgtatttatttcaataggTCTCATAGAAAAAGTATCcggtaatttaatattaaagaaacCTGTATTTAAGTATGTGGGGCCATTTAAGATAAAGAAAGCAGCTGAAGTGTTGGTAACACCTTCCCCCATCACCCCTGTGTCTTGGTTGGATGAGCGGAGACCTTCCTCATCATTAATTTCTACTGGCCGGTCCAAGAGGAAGTTAGAATTCACAACTCCCAGTGCTTCCAGGGAGCTGAAACTGGGCATCACCACCCCACCTCACACTCCATCTCACAAATGGGATGAGATATTACTTGTGGCTGATATGGAACTGACTAGAATTAACAATGGAGTTATGTTGtga
Protein Sequence: MFEDDNITCTPKRYVLTEVTNSSSYVSPTANLKLLTNVALHYPTPPPSAVHRKEKSLQILCDRFLDLYPLHRNGTVEIQLDITAARLGVEKRRMYDIINILEAMQCAVHKKKNTYLWHGGSRLNSFLKMLKKQGEALRLSEALRGRAPKPPAPKHKTLGVLAQRFLMLFLVEPPNTLINLEMAVRVLIDTSNKNKTNLSPEQQDRQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGPFKIKKAAEVLVTPSPITPVSWLDERRPSSSLISTGRSKRKLEFTTPSASRELKLGITTPPHTPSHKWDEILLVADMELTRINNGVML

Sequence clustering based on sequence similarity using MMseqs2