Basic Information

Gene Symbol
-
Assembly
GCA_905220455.1
Location
LR999989.1:5337715-5338294[-]

Transcription Factor Domain

TF Family
zf-LITAF-like
Domain
zf-LITAF-like domain
PFAM
PF10601
TF Group
Zinc-Coordinating Group
Description
Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.6 6.8e+03 -2.3 0.2 15 27 17 29 16 32 0.77
2 2 3.8e-22 9.9e-19 67.6 8.0 1 69 66 138 66 139 0.85

Sequence Information

Coding Sequence
ATGGACCTAAACAATGGGGTAAATCCATCTCAAGGTGATTTTCTGAGGGTACAAACTAATGTGCAACAAGTGACTGCCAGTTACACAAGGACTGCTCCACCACCATACTCGCTCACCGACCCAGCCAACTCAGTGGAAACCAACCAGCCAACTGTCATACATCAGACTATAATCATACGAGGATCACCACTTAAGGATAAACCAGTATATTTTGATTGCCCAAGATGTGGTGAAGCAGTACTTACGAAAGTGCAATATGCAAACACATCTAAAACTCATATGATGGCTGGCTTCCTCTGCGGGCTAACTGTCTGGTGCATGCTGTGTTGTCTTGCTGCAATACCCTATATAATACCATCATTCAAGAAAGCTGAGCACTTCTGTCCAATCTGCAACATATATTTAGGTCATTACACAAAATTCTAA
Protein Sequence
MDLNNGVNPSQGDFLRVQTNVQQVTASYTRTAPPPYSLTDPANSVETNQPTVIHQTIIIRGSPLKDKPVYFDCPRCGEAVLTKVQYANTSKTHMMAGFLCGLTVWCMLCCLAAIPYIIPSFKKAEHFCPICNIYLGHYTKF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00428679;
90% Identity
iTF_00820612;
80% Identity
-