Basic Information

Gene Symbol
-
Assembly
GCA_949752805.1
Location
OX457113.1:7459840-7460416[+]

Transcription Factor Domain

TF Family
zf-LITAF-like
Domain
zf-LITAF-like domain
PFAM
PF10601
TF Group
Zinc-Coordinating Group
Description
Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.3 6.6e+03 -2.0 0.3 14 27 16 29 15 32 0.79
2 2 8.1e-24 2.3e-20 73.1 8.2 1 69 66 138 66 139 0.86

Sequence Information

Coding Sequence
atggACCTAAACAGTGGGGTAAATCCATCTCAAGGTGATTTTGTGAGGGTACAAACTAATGTGCAACAAGTGACTGCCAGTTACACAAGGACTGCTCCACCACCATACTCGCTCACCGACCCGGCCAACTCAGTGGTAACCAACCAGCCAACTGTCATACATCAGACTATAATCATACGAGGGTCACCACTCAAAGATAAACCAGTACATTTTGATTGCCCAAGATGTGGTGAAGCAGTACTTACGAAAGTGCAATATGCAAACACATCTAAAACTCATATGATGGCGGGCTTCCTCTGCGGGCTAACTATCTGGTGCATGCTGTGTTGTCTTGCTGCAATACCCTATGTAATACCATCATTCAAGAAAGCTGAGCACTTCTGCCCAAACTGCAACATATATTTAGGTCATTACacaaaattctaa
Protein Sequence
MDLNSGVNPSQGDFVRVQTNVQQVTASYTRTAPPPYSLTDPANSVVTNQPTVIHQTIIIRGSPLKDKPVHFDCPRCGEAVLTKVQYANTSKTHMMAGFLCGLTIWCMLCCLAAIPYVIPSFKKAEHFCPNCNIYLGHYTKF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00820612;
80% Identity
-