Basic Information

Gene Symbol
-
Assembly
GCA_951394215.1
Location
OX596228.1:1047403-1049757[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 2.6e-06 0.00021 22.1 4.2 1 23 8 31 8 31 0.95
2 21 0.00029 0.023 15.7 0.3 2 23 37 59 36 59 0.95
3 21 4.8e-07 3.7e-05 24.4 0.3 2 23 68 90 68 90 0.97
4 21 1.1e-05 0.00088 20.1 2.0 2 23 99 121 98 121 0.95
5 21 2.7e-05 0.0021 18.9 0.6 2 23 129 151 129 151 0.95
6 21 2e-06 0.00016 22.5 0.8 2 23 159 181 158 181 0.94
7 21 2e-05 0.0016 19.3 5.8 1 23 187 209 187 210 0.96
8 21 0.0076 0.59 11.2 0.9 1 23 218 241 218 241 0.95
9 21 0.018 1.4 10.0 0.1 1 23 260 283 260 283 0.94
10 21 6.6e-06 0.00052 20.8 3.2 1 23 315 338 315 338 0.98
11 21 3.2 2.5e+02 3.0 0.4 2 21 346 365 345 366 0.89
12 21 0.015 1.2 10.3 1.5 3 23 376 397 375 397 0.96
13 21 0.0019 0.15 13.1 5.4 1 23 421 444 421 444 0.97
14 21 9.7e-06 0.00076 20.3 0.6 2 23 451 473 450 473 0.96
15 21 5e-05 0.0039 18.1 2.0 2 23 480 502 479 502 0.94
16 21 0.0071 0.55 11.3 2.2 1 23 508 531 508 531 0.97
17 21 0.18 14 6.9 7.1 2 23 539 561 539 561 0.95
18 21 0.00013 0.01 16.8 0.2 1 23 568 591 568 591 0.97
19 21 0.0025 0.19 12.8 0.3 1 20 598 617 598 619 0.93
20 21 0.016 1.3 10.2 2.7 3 23 636 657 635 657 0.91
21 21 1.4 1.1e+02 4.1 0.2 2 16 678 692 677 694 0.85

Sequence Information

Coding Sequence
ATGTATCAAAATCTCCTAGACTTCATTTGCGATTACTGCAACCGCACCTTCACAAGAAAGTACAACCTTCAAACTCACATAGAGAACTGCCACCTTAATTCGTCATGCTACTGCGAGATTTGCGATCAACGTTTCGGAAGCCCTGCCGGCCTCCAGCTCCACTTGAACCGTGGCCACAACAGATACGCCCAGCCGTACCCAGAATGCGACATCTGTGGAAGAATCTTCACCAGGAAACAGAACCTTATGTCCCACATGATTACGGTGCATTTTCAAGGGAGCGGACCTCAGATTAAATGTCAGCTTTGCGAGAAAACGTTTACCACTGAAAAGAATTTGAGACGGCATACAAATCAGTTACATAATCCTGATGTGCAGTATCCAACATGTGATGACTGTAAGAAGGTATTCAAAGGGAAGCATTCTTTGATAGCTCACATCCAAGCGATTCACAGCTCTGGGAAGGGTATGATCAAGTGTAACATGTGCGATAAGGTTTATACGAATAACAGGAATTTGAAGAGGCATGTGGAGATTTTTCATGGAGATAAAGGAGAATTTCGATGCGATTTGTGTCCTAAAGTGTACACTTCTAATCATAGTCTGAAACGCCATACTAAGTCGCACCATTGCACAGACGATACCGAGCAGTACACTTGTGACTACtgcaataaaaacatatacGGGAGAGATAATTTGGACTCACACATTTCATACTTTCACAAGCAAGACAACTCGATGGACTGCAGCGATGTCGTATCGTCTAAAACGAATGATTTCGCTTGCGATTCCTGCTCGAAAGTCTTTGAAGAAGAGCCTCTTTTACGACAGCACGTTAAAGCCGATCATTCGTTCAAGATATTTTACGAGTACTGCAGAAATTACCTTCTGCTGCAAACGGGAACAACGCCTGAACCCAACATTCACAGCAAAGTTGTTTTATACAAATGCGAATTCTGTCATTATTCATTCTCGAGCGTTTACGAGCTTAAAGATCACATGAGGATTAACCATGATAAAGAATATAGTTTATCGACTTGCAACGTGTGCTTTAGCAAGTTTTACAGCAAGGAAACGATAGCTGATCATAAGAAAATCTGTCTTCCACCTCCAGACGTGAATGCTTGCAGCCACTGCGATAAGCTCTTCACCGATATATCCAGCCTAGAGTTCCACACGCGAATCTTCCATCCTCAAGCACAAATAGCAGACTCCAATATAACTTCTACGAATGAGAATGAAACTCCTGATACTAATTCGTACAAATGCGAGCATTGTGATCGTATTTACTACAGTGATAGATCACTGAAGCATCATATTAAGTTAAAACATACGACGGATGAAGCGATGGAATGCGAATACTGTGGGAAAATCTGCAGCAACAAATACTATTTGGCTTCGCACATTAAAATAGTGCACAGCAATGATTCCTGGTCTAAATGTGGTTACTGCGATAAACAGTTCAAATCGAAGAGGAACATTCGTCGCCACATTGAATACACTCATCTGGGGATGCAAAGGTACAAGTGTATTGAGTGTGAAACTCTGTTTAAAGAGAAACGGAGTCTTCGGAAGCATGTTAGGACTAAGCATCCTAACTCCACTGCCTTTCCCCAATGCCACATTTGCCATAAAAGATTCGAATCGGCTAAATCTTGCAAAATACACCTGAAATTGCTACACTCGTTCAACATGAATACTTTTCCCTGTGACTTGTGTTCTGTTTCATTCAGTTCCAATGAAGCGTTGTCTATACATTTGCAAACGAAGCATTTAGCGGAAGATGAAATATACAAATGTGAGGAGTGCAATCTAGTATTCAAAGGGCAAGAGAAATTTGAGCAGCACAATAATGTATGCCCAGTCAATCTTGAGCCTAATAGCAAGCAGAAGATGCTGCCTAGATGTATCATCTGTATGAAAGACTTCAGCACAAGGAAGACGTTGAAGAGGCACATAAAGAAATTTCATGAGGAATTTGATGTGGATGAATTGGCTACGTTCGGGTCGAGGCGAAGAGACTTCGTTGTAGAATGCGACGATTGTCTCAAGAAGTTTAACGATGATGCTCATTTCAACTTGTATCAGAAGCTGAAGCATTTGAGAGACGCTTCCATCTTTACTTGTGAGACGTGCTCAGCATCATACAATCCATTTGAATACTACATTCAGAGATACAAGCTGACTACTTTCGATATTAGCAAGAGTAAGATGATTCTGAGTGAGTTGTGTACAGCAGAGATGAGTGATGAGGAGTCTTCGTATATGGGATTCGGGTCTCTTCATGAGACTATGGAGGCGGAGAGTACTACCAGCGATATCAAGTTGGAACCTGTTGATGAGGTTTCGGAGTGA
Protein Sequence
MYQNLLDFICDYCNRTFTRKYNLQTHIENCHLNSSCYCEICDQRFGSPAGLQLHLNRGHNRYAQPYPECDICGRIFTRKQNLMSHMITVHFQGSGPQIKCQLCEKTFTTEKNLRRHTNQLHNPDVQYPTCDDCKKVFKGKHSLIAHIQAIHSSGKGMIKCNMCDKVYTNNRNLKRHVEIFHGDKGEFRCDLCPKVYTSNHSLKRHTKSHHCTDDTEQYTCDYCNKNIYGRDNLDSHISYFHKQDNSMDCSDVVSSKTNDFACDSCSKVFEEEPLLRQHVKADHSFKIFYEYCRNYLLLQTGTTPEPNIHSKVVLYKCEFCHYSFSSVYELKDHMRINHDKEYSLSTCNVCFSKFYSKETIADHKKICLPPPDVNACSHCDKLFTDISSLEFHTRIFHPQAQIADSNITSTNENETPDTNSYKCEHCDRIYYSDRSLKHHIKLKHTTDEAMECEYCGKICSNKYYLASHIKIVHSNDSWSKCGYCDKQFKSKRNIRRHIEYTHLGMQRYKCIECETLFKEKRSLRKHVRTKHPNSTAFPQCHICHKRFESAKSCKIHLKLLHSFNMNTFPCDLCSVSFSSNEALSIHLQTKHLAEDEIYKCEECNLVFKGQEKFEQHNNVCPVNLEPNSKQKMLPRCIICMKDFSTRKTLKRHIKKFHEEFDVDELATFGSRRRDFVVECDDCLKKFNDDAHFNLYQKLKHLRDASIFTCETCSASYNPFEYYIQRYKLTTFDISKSKMILSELCTAEMSDEESSYMGFGSLHETMEAESTTSDIKLEPVDEVSE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00365110;
90% Identity
iTF_00408636;
80% Identity
iTF_00408636;