Cpri002546.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cryptocephalus primarius
Gene Symbol
RHOBTB1
Assembly
GCA_963576515.1
Location
OY754937.1:9575812-9585316[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.8e-09 5.4e-07 30.0 0.0 3 49 269 314 267 330 0.80
2 3 6.9e-06 0.0021 18.4 0.0 48 103 372 426 360 429 0.83
3 3 1.1e-17 3.3e-15 56.4 0.1 5 107 455 556 452 559 0.93

Sequence Information

Coding Sequence
ATGTCGGCACCAGTCGCAGAGCCGTCGTGGTCTTGGGGAATGGATAATGAACAACCCCACCAGGAGTTGGTCAAGTGCGTCGTGGTGGGCGACACGGCCGTAGGCAAGACGAGGCTGATATGCGCGAGGGCGTGCAACAAGCAGGTGTCGCTGGCCCAGCTGCTGGCCACGCACGTGCCCACCGTTTGGGCCATCGACCAGTACAGGATATACAAGGATGTCCTCGAGAGGTCCTGGGAGGTCGTCGACAGCGTGAACGTCAGCCTCAGGCTGTGGGACACCTTCGGGGACCACGAGAAGGACAGGAGGTTCGCGTACGGCCGTTCCGACGTGGTACTACTATGCTTCAGCATCAACAACCCAGTATCTTTAAGGAATTGTCGACTGATGTGGTTCCCAGAAATCCGTCGCTTTTGTCCCAACACCCCCGTTCTTCTCGTCGGTTGCAAGAACGATTTAAGGTACATGTATCGAGACGAAGCATACCTAAGTTACTTCCGAGATCGAAGCCCATTTGTAAGAGCCACGAGGAAGAGCGATCTGGTGATGCCGGACGAAGCGAGGGACGTGGCCAGTGAACTTGGTCTTTACTACTACGAGACTTCGGTACTTACTTATTACGGTGTCAACGAAGTATTCGAGAACGCGATCAGAGCCGCGCTGATTGCGAGAAGAGCGCAAAGGTTCTGGATGACAAACTTGAAGAAGGTGCAGAGACCACTCCTGCAGGCGCCTTTCAAGCCACCTCCGCCCCTGAAACCCGAGGTTCACATTTCGCCCAGCTCTTACAAGGAACACATGCAACACCTCTGGCTGAGTCGAGCTCATACCGATGTAGTTTTAGTCGTAGGCTCGATGGGATTTTCTGCACACAGATTTATACTCGCAGCCAGTAGTGGTGCGTTCTACAGACTCCTGACTGCCGACCTGATGGCGAGGAGCACGAGCGACTCGTCGATGGTATCCTCCCTGGGCGACTTCGCCGACGAAACGGAGTGCCTCGTCAGGGCCGAGCAGAAGACCTGCAAGAGGAGGGCGAGCTGCCAGGCGCTGCCCTCGGCGAGGGACCTCGACCATCCCGCCTTCACGTGCATCAGGAACGTCCAGCCCGAGGGGCAGACCGTCGTCACGCTCAGCAAGCTCGTCACCGCGACGGCGATGAGGCAGTGCCTCCAGTTCGTCTACACTGGGACGGTCGACAGGAGCGTACTGAACCTGAGGGAGACCTGCGAGGCGGCCGAGCTGCTCGACCTGCCCCAGCTCCTGGTGCTCCTGACGAAGCACCCCTTCGTCGCCCCCGAGCCTCCAGAGGACGACGTCGGATACGACGACTACCTGAAGCGACGCCTCCGGGACGTCTGCCTCGAGCAGGGAATGTTCGCCGACGTCATCTTCGAGGTGGACGACGGGGCCTGCACCGCCCACAAGGCGATGCTGACCGCCAGGTGTGACGTGATGAAAGCGATGTTCGGCGGAGATTTCAGGGAGAGCCAGGCCAAAGTGATCGAATTTCCTGGTGTTCGCGAATACACATTCCACAAGCTGCTGTGTTTCCTTTACACCGATGACATTCCTGCTGTATCGGCGGTAAGGTGCTTGAATCTGTTGGAGCTCGCCAACAGGCTGTGCCTGCCGAGGCTAGTAAATCTGGTCGAGATGAGGGTCATTGAAGACCTGGAACGGTTACAGTCCTCAGAGGCCATCGAGCAGTGCTTGCGGCTCCTCGAGCCGGTCAAGTTGCACAACGGCCACCAATTGGCCGACTGGTGCATGAACCACCTCTGCGTGAACTACAACAAGCTGTGCCGGATGTCGCCTCGTTCCCTGCGGCTGCTGCACCCGGACAACCAGGCGTATCTGGTGGAGCACCGCTGGCCCCCCGTCTGGTACCTGAAGGACTACGACTACTACCAGAAGTGTCTGGCGGAACGCGACAAAGAACTGAAACCGAACGATAACAGGAGTTCGGGCTGTCTGTGCTTCTCCAGGAAGTCCGAATCGGATCCTGCGTTGTCGTCCAGTCAGTTGTGA
Protein Sequence
MSAPVAEPSWSWGMDNEQPHQELVKCVVVGDTAVGKTRLICARACNKQVSLAQLLATHVPTVWAIDQYRIYKDVLERSWEVVDSVNVSLRLWDTFGDHEKDRRFAYGRSDVVLLCFSINNPVSLRNCRLMWFPEIRRFCPNTPVLLVGCKNDLRYMYRDEAYLSYFRDRSPFVRATRKSDLVMPDEARDVASELGLYYYETSVLTYYGVNEVFENAIRAALIARRAQRFWMTNLKKVQRPLLQAPFKPPPPLKPEVHISPSSYKEHMQHLWLSRAHTDVVLVVGSMGFSAHRFILAASSGAFYRLLTADLMARSTSDSSMVSSLGDFADETECLVRAEQKTCKRRASCQALPSARDLDHPAFTCIRNVQPEGQTVVTLSKLVTATAMRQCLQFVYTGTVDRSVLNLRETCEAAELLDLPQLLVLLTKHPFVAPEPPEDDVGYDDYLKRRLRDVCLEQGMFADVIFEVDDGACTAHKAMLTARCDVMKAMFGGDFRESQAKVIEFPGVREYTFHKLLCFLYTDDIPAVSAVRCLNLLELANRLCLPRLVNLVEMRVIEDLERLQSSEAIEQCLRLLEPVKLHNGHQLADWCMNHLCVNYNKLCRMSPRSLRLLHPDNQAYLVEHRWPPVWYLKDYDYYQKCLAERDKELKPNDNRSSGCLCFSRKSESDPALSSSQL