Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.36 6.7e+02 0.8 0.0 16 45 91 120 81 124 0.78

2 6 0.00029 0.54 10.7 0.0 22 52 153 183 144 185 0.88

3 6 0.18 3.3e+02 1.8 0.0 23 43 182 202 178 207 0.88

4 6 0.029 54 4.3 0.1 22 46 209 233 203 236 0.90

5 6 0.0045 8.4 6.9 0.0 22 52 237 267 233 267 0.87

6 6 0.033 61 4.1 0.0 22 46 265 289 262 295 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.36	6.7e+02	0.8	0.0	16	45	91	120	81	124	0.78
2	6	0.00029	0.54	10.7	0.0	22	52	153	183	144	185	0.88
3	6	0.18	3.3e+02	1.8	0.0	23	43	182	202	178	207	0.88
4	6	0.029	54	4.3	0.1	22	46	209	233	203	236	0.90
5	6	0.0045	8.4	6.9	0.0	22	52	237	267	233	267	0.87
6	6	0.033	61	4.1	0.0	22	46	265	289	262	295	0.86

Coding Sequence: ATGAGCGACACCTGCGATTGGTGCTCGCGGGGGGCACCAGTGAAAACGATCGACGAGAGGTTGTGGCGCTTTTGGGGAGTGATCAGCGGCGAAAGACCGCTCGACGAATCCTTGAGGAAGATCTGCGGGGAGTGTACGTCGCGCCACGAGGACTTCTCGACGTTCATCGACAGGTGCAAGAGCAACGAGTCGCTCGTGGAGAACTTTCTCGCCCCCTTCGACATCGAGTACCATCCCTTGATCAAATCGGAGCGTCCGACAGACGAGAGTACCGCAGCGTCCGTATCGAACGTCGcattcaagtgctcgctttgcgtcgagaccttcgccgatctcgccgtcctgaagcgccacctacgagcccacacgatcgatgaggccccgaggtgccggctctgcgacaagacgttccgtcggtactattacctcgagagccacatgcgaatccacaccggcgacaggccgttcaagtgtccccactgcgacaagactttcacgcagtccggtaacatgaagagccacttacgtgtccacacgggcggtaagccgttcaagtgtccgaagtgcgataagacattcgctcggtatggcaacctgagggaccactcgatcgtccacacgggcgaagcgccgtacaggtgttctcagtgcgacaagacgttcgcccagtcgagtaagttgaagagccatctgcgcgtccacacgggcgacaggccgttcgagtgtccgcactgtgacaagaagttcacgcagcacggcaacctgaagagccacgttcgcctccacacgggcgacaagccgttcaagtgtccgaagtgtgataagggcttcgcccaatcgagtccgttgaagggccacatgcacgtccacggcgtcgtggaacctttcgagtgtaccgtctgcg
Protein Sequence: MSDTCDWCSRGAPVKTIDERLWRFWGVISGERPLDESLRKICGECTSRHEDFSTFIDRCKSNESLVENFLAPFDIEYHPLIKSERPTDESTAASVSNVAFKCSLCVETFADLAVLKRHLRAHTIDEAPRCRLCDKTFRRYYYLESHMRIHTGDRPFKCPHCDKTFTQSGNMKSHLRVHTGGKPFKCPKCDKTFARYGNLRDHSIVHTGEAPYRCSQCDKTFAQSSKLKSHLRVHTGDRPFECPHCDKKFTQHGNLKSHVRLHTGDKPFKCPKCDKGFAQSSPLKGHMHVHGVVEPFECTVC

Sequence clustering based on sequence similarity using MMseqs2