Basic Information

Gene Symbol
-
Assembly
GCA_949320105.2
Location
OX439473.1:12027659-12034332[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.056 7 8.4 2.3 2 23 155 176 154 176 0.96
2 16 2e-05 0.0025 19.3 4.5 1 23 181 203 181 203 0.98
3 16 0.0009 0.11 14.1 4.1 1 23 209 231 209 231 0.97
4 16 0.0098 1.2 10.8 2.1 1 19 237 255 237 256 0.96
5 16 2.4e-06 0.0003 22.2 0.2 1 23 265 287 265 287 0.98
6 16 0.01 1.3 10.8 0.5 1 23 532 555 532 555 0.96
7 16 8.2e-05 0.01 17.4 4.6 1 23 561 583 561 583 0.98
8 16 4.3e-06 0.00055 21.4 5.1 1 23 589 611 589 611 0.98
9 16 1.5e-05 0.0019 19.6 2.1 1 23 617 640 617 640 0.94
10 16 0.01 1.3 10.8 1.2 1 23 654 676 654 676 0.87
11 16 0.00014 0.018 16.6 4.3 1 23 682 704 682 704 0.98
12 16 2.3e-06 0.00028 22.3 0.5 1 23 711 733 711 733 0.96
13 16 2.9e-06 0.00036 21.9 1.2 1 23 739 761 739 761 0.98
14 16 4.3e-07 5.4e-05 24.5 0.9 3 23 769 789 767 789 0.96
15 16 2.1e-05 0.0026 19.2 0.1 1 23 795 817 795 817 0.99
16 16 0.059 7.4 8.4 0.7 1 23 822 845 822 845 0.97

Sequence Information

Coding Sequence
ATGGAGATAGAAAACGTGAATCTTAATCGGATTTGCCGTACGTGCAAATGCGTTAGTCCTCATATGCGTTCCTGTTTTGAGGGTTATGAAAATCCTCATCAGAGTCCCCGTATTGACGAGATGCTAATGGCCTGTGCTTCAATTCAGGTGATCTGTGGAGACGGTTTGCCGACTTTGATATGCCAGATATGTGTAGAACAGTTAAAAACTGCTTATATCttcaaaagacaagcagaaaggGTAGATATGGGTTTAAGAGAGTACGCAAAAAATCTCAAAGTAAATGAAATTAAACAAGAATTACAAAATTCTGAGTTTATGGAATCTCTTAATACACTGGACAGTATCTTAAATGACCAGGCAACATCTAAGGATACCGTAAATACAGGAGAAGTGGTACCTCCACCCCCTAAATTTGAAACTGATTATATTCAATTTATGGACAACAATCAAATGTTGCTCACATGTCGGGAGTGTGCTAAGATGTTCACTACTCTGGAGggCCTGCGATGCCATAAACGCATTCACACTGGTGGCATGTATAAATGCAAACAGTGCGACAAAGAATATACAAGACTTAATCATTTACAAAGACATGAACAATCTCACAATAGACGAAAAGTACATGTGTGCAGAATCTGTAGTAAGACATTGACTAGAATGGAGCATCTGAAACGTCATTTGGTTACTCATCTCAGGGAGAAGCCATTTTCTTGTAAAACATGTAATAGAGGCTTCAATAGAATTGAACATTTGCATAATCATGCTCCTAGGTGCAAAGgtGACACTGTATATCCTTGTGATATTTGCAACAAGGCGTTTAATCGTGAAGACAGCCTTGAAGTTCATAAAAAAATGCACGATAACCAAGCTCCAAAATTGCCAACCATTGAAAATCTGGACAACATAGAAGATCACTACTACCAAATTGATCAAGATAATACTACCGTTGACTTTTCTGATCATTCTGATGTCGATGATTGTTTTGAACCCCAAGTTGAGGTTACTGAGACAGAAGATGATAAACTTAAGgttGTTACTGAAATTTCAAATCAGGATCAAgatcaagaagaagaagaaagcaTACACAGTGATGTTGATGGTGATAATGATGATGTTGCTTCAATGGGAGGTGCAGATATAGATAATGATAGTGATATGGATGATCTTGACAAGGATAATGACGAAAATGACCCAGACAGTTCTGAGGAAAGAGAAAATAAACAGATGCCTCTTGGTCATGAAATAACTGATGAAGAAAAATTAGATGTAAAAGTCGAAACTCCTAAATTAAATGACGAGGAAGAAGAATACATGAAACAGGCTATTGCTGATGCAGAAGCTGATGATGAAGATGATGATTCCGACAAAGATAGTGCCGATTCTGATTACACGCCCAAAAAGACTGCCGTCAAAGTAAAACGCGGTAGAGGTAGACCTCGCAAAAATCCTGATGAACCTCCTAAAGCTAAAAAGCTGAAATCATCCAAAATCCCCGGAAAGAGAGGTCGTAAACCTGGATCAAAGAATAAAATCAAAGAGCCTGGAGAAATCTCTGTTAAAAGAGAAAGAGATGATGATGATTATGGAGAATTTCCTTGTCCAATTTGTAATGAAATGTTCCACAGTATTCTTAAGTTGGACAAACATGCAAGGGTGAAACACGAGGGATCTAAGATTCACAAATGTAACGTGTGCCAGAAAGAATTTGCTCGTATAAATCACCTAAAGAGACACATAACGTCCCATTCAAACATTAAACCCTTCCGATGTACTGTATGTACAAAGAGCTTTAACAGACGCGACCACCTTAACCAGCATCAGAAATTGCATGATAGACAAAATGACCACGAATGCGACATATGTCAAAAACCATTCTCTAGAGCCGATCACCTCGCTAAACACAAAGCCTCGAAGCATGGCATAGGAGAGCGAATTTCGATGATCGGTGAAAAGAAGTATGAGTGTCCGCTGTGTCACAAATTCTTCACCACCGAAAAATACAGGGATGTTCACGTGGCCGGCCATAATGGCACCAAAGAATATTCGTGCAAAGTGTGCGAGAAAACGTTCCTATCGAAGTCGCATTTGACGGAACACATGAAATTCCATAATGAACATTCCAAGAAATTCCTCTGTTCCGAATGTGGACAGAGATTTATTAGAAACGATTATTTGGTAATCCACATGAGAAGACATAGAGGTGAAAAGCCGTTCAAGTGCAAATACTGTGGCAAAGGTTTTCCTAGAACGACAGATCTTACTGTACATGAGAGATATCACACAGGGGAAAAAACTCATTTATGTACTATTTGTGGAAGAGGGTTTGGAAGggCGTACAATTTAACAGTGCATATGAGAACACACACTGGAGAAAAACCATATCAGTGCACATATTGTGATGCTGCTTTCGCTCAAGGAAACGACTTGAAGGCCCACGTTAGAAGACACACTGGAGAACGGTTTCAATGTGAATTGTGTACTGAAAGTTTCCTTATGGGCTATTTATTGACTCAACACAAACGAACAGTTCACGgACTAAATGTTGTGAGCAACATTAGAAGGTTGCAACCTGTCCACAAGCAGGAAAATCCAGATGAACCACCACCAATAACAATACCGTTGCCGAAACCAGTTATTCCAGACAATGTTATGTTTAACGCCTTACATGCAAACGCACTACATGCTAATGCTCTTCATGCAAACGCTCTCCATGCTAACGCCCTTCACGCGCAGTTAGCCGTTGCGCAGCTCCATTTAGCCAGAGAATAA
Protein Sequence
MEIENVNLNRICRTCKCVSPHMRSCFEGYENPHQSPRIDEMLMACASIQVICGDGLPTLICQICVEQLKTAYIFKRQAERVDMGLREYAKNLKVNEIKQELQNSEFMESLNTLDSILNDQATSKDTVNTGEVVPPPPKFETDYIQFMDNNQMLLTCRECAKMFTTLEGLRCHKRIHTGGMYKCKQCDKEYTRLNHLQRHEQSHNRRKVHVCRICSKTLTRMEHLKRHLVTHLREKPFSCKTCNRGFNRIEHLHNHAPRCKGDTVYPCDICNKAFNREDSLEVHKKMHDNQAPKLPTIENLDNIEDHYYQIDQDNTTVDFSDHSDVDDCFEPQVEVTETEDDKLKVVTEISNQDQDQEEEESIHSDVDGDNDDVASMGGADIDNDSDMDDLDKDNDENDPDSSEERENKQMPLGHEITDEEKLDVKVETPKLNDEEEEYMKQAIADAEADDEDDDSDKDSADSDYTPKKTAVKVKRGRGRPRKNPDEPPKAKKLKSSKIPGKRGRKPGSKNKIKEPGEISVKRERDDDDYGEFPCPICNEMFHSILKLDKHARVKHEGSKIHKCNVCQKEFARINHLKRHITSHSNIKPFRCTVCTKSFNRRDHLNQHQKLHDRQNDHECDICQKPFSRADHLAKHKASKHGIGERISMIGEKKYECPLCHKFFTTEKYRDVHVAGHNGTKEYSCKVCEKTFLSKSHLTEHMKFHNEHSKKFLCSECGQRFIRNDYLVIHMRRHRGEKPFKCKYCGKGFPRTTDLTVHERYHTGEKTHLCTICGRGFGRAYNLTVHMRTHTGEKPYQCTYCDAAFAQGNDLKAHVRRHTGERFQCELCTESFLMGYLLTQHKRTVHGLNVVSNIRRLQPVHKQENPDEPPPITIPLPKPVIPDNVMFNALHANALHANALHANALHANALHAQLAVAQLHLARE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01047646;
90% Identity
iTF_00792380;
80% Identity
-