Basic Information

Gene Symbol
LZTR1
Assembly
GCA_949320105.2
Location
OX439472.1:40691748-40696070[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 2.3e-10 1.3e-07 32.8 0.0 3 108 353 490 351 492 0.89
2 4 0.27 1.6e+02 3.7 0.2 78 109 492 523 489 524 0.87
3 4 9.6e-16 5.6e-13 50.2 0.0 8 97 583 672 578 686 0.83
4 4 1.4 8.4e+02 1.3 0.1 76 101 685 710 681 718 0.79

Sequence Information

Coding Sequence
atgagccTCAGTGCGGGTGAGGCCAGTGCCTTAACTTTGGAAATCGGTCCGTTCGAGACTGTGCATAGATGGAGACGAATGCCCGAATGTGATGAATTCGTAGGAGCTAGaaGGAGCAAACACACAGTGGTCGCTTATAAGGATGCAATATATGTTTTTGGGGGTGACAATGGTAAGAGCATGCTTAACGATCTGTTACGTTTCGATGTTAAGGAAAAAAGTTGGGGGCGGGCATTCGCCACTGGGACTCCCCCTGCTCCAAGGTATCACCACTCTGCAGTAGTGTACAATAGTTCTATGTTTGTTTTTGGTGGATACACAGGTGATATTCACTCAAACTCGAatcttacaaataaaaatgatttgtttGAATACAAATTTACTTCGGGGCAGTGGATGGAATGGAAGTGGTACCCAGGTCCCATACCTGTTCCTAGATCAGCCCATGGAGCTGctatttttgataataaattatGGATTTTTGCTGGTTATGATGGTAATGCTAGATTAAATGATATGTGGACTATTAATTTATTGGGAGAAACTAAAATTTGGGAGGAAGTTAGCCAAAAAGGAGAATGTCCCCCAACTTGCTGCAATTTTCCTGTGGCCGTTGCTAGGGATTGTATGTTCGTTTTCAGTGGTCAAAGTGGTGCTAAAATCACCAACTCTCTATTTCAATTTAGCTTTACAGACAAGACATGGACACGAATCTCGACCGAGCACATCCTCAGAGGTGCTCCTGCTCCTCCGGCTCGTCGTTACGGCCACACGATGGTCGCTTACGATCGCCATTTGTATGTTTTTGGAGGCGCGGCCGATTCGACTCTCTCCAACGACTTGCATTGCTTCGATTTAGACGCCCAAAAATGGACCATAGTTCTTCCTGATCCGGAATCGTTCGTACCTTCCGGTAGATTATTTCATGCTGCCGCTGTGGTTGGAGAAGCGATGTTTATATTTGGTGGTACCGTCGATAATAATGTCAGGAGCGGGGAAATGTATAGGTTTCAGTTCTCTAATTACCCAAAATGTACCCTACATGATGATTACGGTAAACTACTCGAATCCAGGCAGTTTTGCGATGTAAAATTTTTAGTGGGACCCGAGGAAGATACCATACTAGGACACGTAGCGTTAGTGGCCGCCAGATCTGGTTACTTAAGAAAAAGAATCCGCAAAGCCAGCGAAAATCGGGATAGACATCTAGAAAATCTCTTTGGAACAGTAAATGTTTCTTTTACCGATATTCCTCTTCTGGAAGTTAAACTACCGGACGCTAATCCGGAAGCTTTCGAAATGGTTTTAAACTATATTTATATGGACTGTATTGATCCTACGAAGCGAGCTAGGGATGAGGAAGATCCTGTGTCTAATAGGATAGTCCTCAGAATGATGGATGTTTACagGTTGGCAGTACAATTCAACATGGCACGATTGGAACAACTTTGTGTTCAGTATCTAAACGCAaccatttgtttaaaaaatgtccTCATAGCTTTGCATAACGCAGATCAACTTCATTTAGAGTATATAAAGGAACACTGTTTGAGGTACATAGTAAAAGAGAGCAACTATAATCAAATAGTGATGAGTTCTGAGTTCGAATCTTTAGAAAGGAATCTCATGGTCGAGATTATCAGAAGGAAGCAAATGCCTCAATATAAGGCTAACAATGAGGCAACATTCGACACCGCCGGTGGATCCTTAGAACAAGATATGGCCATGTTTTTAAGAGTAACTGGAAAAGAATTTTGTGATATAGACTTGAATTTGGATGGAATACTTATTTCTGCGCATAAAACGATTTTAGCTGCAAGATGTGCTTATTTCGAAGGAATGTTTAGGTCCTTTATGCCAGCTGACAGCAAAGTTAATATTCAAATAGGCGAGTTGATTCCTTCGAAAGAATCATTCGACTCTCTTTTACGATATATTTATTACGGTGATGTTAATATGCCTCCCGAAGATTCTCTATATCTATTTTCTGCTCCATACTTCTACGGTTTCCACAACAACCGACTTCAAGCTTTCTGCAAACAGAATCTCGAGATGAATGTCACCTTTGAGAACGTCATTCAAATTTTGGAAGCCGCCGACAAGATGAACGCCACCGATATGAAGAAATACGCACTTGATTTGATCGTCCATCATTTTACCaaaGTTGCAAAACTGCCAAAGCTCAAGATGCTGAGCAAAGAATTGATCTTAGACATCTTGGAGGTTTTGGCAGAGAGCATGGAGCAAAATATGAGGAACGATGTATCGAGCGGTTTGATAAATTTGGATCCATGA
Protein Sequence
MSLSAGEASALTLEIGPFETVHRWRRMPECDEFVGARRSKHTVVAYKDAIYVFGGDNGKSMLNDLLRFDVKEKSWGRAFATGTPPAPRYHHSAVVYNSSMFVFGGYTGDIHSNSNLTNKNDLFEYKFTSGQWMEWKWYPGPIPVPRSAHGAAIFDNKLWIFAGYDGNARLNDMWTINLLGETKIWEEVSQKGECPPTCCNFPVAVARDCMFVFSGQSGAKITNSLFQFSFTDKTWTRISTEHILRGAPAPPARRYGHTMVAYDRHLYVFGGAADSTLSNDLHCFDLDAQKWTIVLPDPESFVPSGRLFHAAAVVGEAMFIFGGTVDNNVRSGEMYRFQFSNYPKCTLHDDYGKLLESRQFCDVKFLVGPEEDTILGHVALVAARSGYLRKRIRKASENRDRHLENLFGTVNVSFTDIPLLEVKLPDANPEAFEMVLNYIYMDCIDPTKRARDEEDPVSNRIVLRMMDVYRLAVQFNMARLEQLCVQYLNATICLKNVLIALHNADQLHLEYIKEHCLRYIVKESNYNQIVMSSEFESLERNLMVEIIRRKQMPQYKANNEATFDTAGGSLEQDMAMFLRVTGKEFCDIDLNLDGILISAHKTILAARCAYFEGMFRSFMPADSKVNIQIGELIPSKESFDSLLRYIYYGDVNMPPEDSLYLFSAPYFYGFHNNRLQAFCKQNLEMNVTFENVIQILEAADKMNATDMKKYALDLIVHHFTKVAKLPKLKMLSKELILDILEVLAESMEQNMRNDVSSGLINLDP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01186316;
90% Identity
iTF_00056724;
80% Identity
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