Basic Information

Gene Symbol
Rfx2
Assembly
GCA_949710015.1
Location
OX453290.1:9669898-9675339[-]

Transcription Factor Domain

TF Family
RFX
Domain
RFX domain
PFAM
PF02257
TF Group
Basic Domians group
Description
RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 2 1.8e+04 -3.9 0.6 10 30 40 60 34 70 0.57
2 4 1.2 1e+04 -2.8 0.2 15 46 125 156 121 157 0.73
3 4 2.8e-38 2.4e-34 117.7 0.1 3 78 364 439 362 440 0.97
4 4 1.3 1.1e+04 -3.0 0.1 25 43 822 840 820 843 0.83

Sequence Information

Coding Sequence
ATGCATCCGCGATTAAATTGGgatcagcaacagcaacaactacaattacaacaacatatacgATTTAAGTGTCATTGCAAGGTGCAATCGCACCACCAAGCACTCAGctgcagcaacaaaaacattaacaaaaataatcacTACTCAAATCGACGCCAGTGCAATCATCAACAATATCGACCAAAgtatcaccatcaccatcacttGCAACAACAATTCCAAACGGGTCTATACCAAAAACATCATCATcagaaacaacaaaataattatcaatatCAATCAAtagctgttgctgctgctgctgccgccACTGTGTTACCGATCAAATCTTATCCTGCATCGTGTGCTGAACCTCAGTTTgttcaacaacagcaacatcaacaatCGATTTCTCACCATTTACACCATCACCActaccatcatcatcaccatcaagCATTTACCGCATCCACGACTACGACAAACTTTTCACCATCATCCTGTGCCGCCGCTTCAATCGATCACTCATCCACAGCGACTTCTATTAATCAATTGGAGACGATAGGAACGACCATGTATCGCCGCCAAAATAATTTATCCTATTGTGGTGtATCCGCTCAAGATGCTGGTCAAAACTATCAAGTACAATACGTTGACACCGACATATATCATAGCAACTCTAGTCAAACTCAAATGGCCTATCCGTTTTGTGCCGTTGGAGATTACCAAACGAATGGTCAGTCTTATTATACCACCACGGCCACCGGTAATTATACATCATCAGGAAGCTTGAATACACCAAATACACATGCGGCATCGGCTGCTCTGTCATACCTGGTGCCAGTTGATGACAATTTGTTACTGACTTCGTCATCGCAATCGCACAGCCGAGATTCGCCGAATAGTTTAAATGAGGTGGCTTATCTGCACGAAGCGCACGGTACACCCCAACCGAATGCTTCAATGGCAACGATTGCCAACTCAATTGGCTGTGATGGTGGTGACGGTGGTATGAGTTCCGGTGCCAACAATGTGTGCAGTGGTGGTGATACCACACCAGAAAACGACCAAACACAATTGAGCAACAATACTACGAATAAAATTGCTTCGGCAACGATAAAATGGCTGTCGCGAAATTACGAAACTGCAGATGGAGTCAGTCTGCCACGCTCCACTCTTTACAATCATTATATACAGCATTGCAATGAGAATAAAATCGAACCAGTTAATGCGGCCAGTTTTGGAAAATTAATACGCTCGGTGTTTTCTGGTTTGCGTACAAGACGTTTGGGTACACGCGGCAACTCTAAATATCATTACTATGGCATACGCATTAAACCGGACTCCCCGCTAAACCATATGATGGAGGAAAAAGACTCCTTTATATTACAAGCGGCTACCTCGTCCGGAGGCGTAGGTAAAACAGCAGCCGGAGGTAACCCAATTTTTCAAATGAGTGGCGGCAGTCTCCAAGATAATCGCATTGGTCCATCTCGTGGTGGCATTCACGTCAGTAGAACTTccaaaaaacattattttaaacCAGTGTCCTATGAAACGTGTGCTCAATTCTTGGGTAATGGATCGGCAGCCATACCGCCATTTCCTCCCATTCAATTGGACAACACATTCGGCAGTGAACTAACTAATGAAGATGTGGATTTGTTTCGCTCCATGTATCGTGAACACTGTGAAAATTTCCTGGATGCTATTCTGAATTTGGAGTTTCAtacaattgaatttttatggcGTGAATTTTGGCGCGATAGCAGCATCGACAATAGCAGTCTAGGCGACGATTGTGTTGGGACCAGTGAAGAgaaatttttaagcaaaacCAAGTTGCACCTGTTATGCCATTGTACAGCCGTTCAGCGATTTGTGCAAGAGGTGGACTATCAATTTTATCAAAACTTAGTTGAAATCATTGTACCGGACGTATTGCGTTCGATACCAAATGCACTTACTCAGGCTATACGtaatttttcgaaaaacaTGGAAGCCTGGTTATGTGAATCTATGCTTGGGGTACCAGAGCGCATGTTGCATATAAAGTCTGTGGCGGTGTCAGCTTTCTGCCAAACCCTACGCCGTTACACATCTTTGAATCATTTGGCACAAGCTGCTCGAGCTGTTTTGCAGAACAGCACACAATGCGCTCAAATGTTGCATGATTTGAATCGTGTTGACTTTCATATTGTTCAGGAACAGGCAGCTTGGGTTTGTCAATGCGATCCAATTGTTGTGCAACGTTTAGAAAATGGTTTTAAAGCTGCCTTGCAACAGCAGAGCACCTTGGAACAGTGGGCTACTTGGCTACAATTGGTCGTCGACTCAGCATTACAAGACTATCATGGAAAACCCAGTTTTGAGAAAGCATGTCGTCAGTTTCTACTTAAGTGGAGCTTTTACAGTTCCATGGTTATCCGAGATCTCACTTTACGTTCAGCCCCTAGTTTTGGtagttttcatttaatacgGCTTTTGTACGATGAGTATATGCTCTACTTGGTGGAACATAAAATAGCTGAAgttcaacaaaaaacaacaattgccGTAGTTTGTGATCATGTAAAAAGAGATGCCGAAAGTGAGTTCGATTATCAAGTAGAGTTTATAGCATCAGAAAGCACGGGTTCTGAGCAAGCATCCAAACGTTCAAAACAGGAATGA
Protein Sequence
MHPRLNWDQQQQQLQLQQHIRFKCHCKVQSHHQALSCSNKNINKNNHYSNRRQCNHQQYRPKYHHHHHLQQQFQTGLYQKHHHQKQQNNYQYQSIAVAAAAAATVLPIKSYPASCAEPQFVQQQQHQQSISHHLHHHHYHHHHHQAFTASTTTTNFSPSSCAAASIDHSSTATSINQLETIGTTMYRRQNNLSYCGVSAQDAGQNYQVQYVDTDIYHSNSSQTQMAYPFCAVGDYQTNGQSYYTTTATGNYTSSGSLNTPNTHAASAALSYLVPVDDNLLLTSSSQSHSRDSPNSLNEVAYLHEAHGTPQPNASMATIANSIGCDGGDGGMSSGANNVCSGGDTTPENDQTQLSNNTTNKIASATIKWLSRNYETADGVSLPRSTLYNHYIQHCNENKIEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPDSPLNHMMEEKDSFILQAATSSGGVGKTAAGGNPIFQMSGGSLQDNRIGPSRGGIHVSRTSKKHYFKPVSYETCAQFLGNGSAAIPPFPPIQLDNTFGSELTNEDVDLFRSMYREHCENFLDAILNLEFHTIEFLWREFWRDSSIDNSSLGDDCVGTSEEKFLSKTKLHLLCHCTAVQRFVQEVDYQFYQNLVEIIVPDVLRSIPNALTQAIRNFSKNMEAWLCESMLGVPERMLHIKSVAVSAFCQTLRRYTSLNHLAQAARAVLQNSTQCAQMLHDLNRVDFHIVQEQAAWVCQCDPIVVQRLENGFKAALQQQSTLEQWATWLQLVVDSALQDYHGKPSFEKACRQFLLKWSFYSSMVIRDLTLRSAPSFGSFHLIRLLYDEYMLYLVEHKIAEVQQKTTIAVVCDHVKRDAESEFDYQVEFIASESTGSEQASKRSKQE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01113947;
90% Identity
iTF_01113947; iTF_01114750;
80% Identity
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