Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.89 5.2e+03 -2.0 0.1 18 30 76 88 73 91 0.78

2 6 0.018 1e+02 3.5 0.1 21 45 107 131 101 138 0.82

3 6 2.2e-05 0.13 12.8 0.1 22 44 136 158 130 162 0.89

4 6 0.00038 2.2 8.8 0.2 21 45 163 187 158 193 0.89

5 6 0.00037 2.1 8.9 0.6 20 45 193 218 186 222 0.84

6 6 0.00032 1.8 9.1 0.1 18 46 219 247 218 251 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.89	5.2e+03	-2.0	0.1	18	30	76	88	73	91	0.78
2	6	0.018	1e+02	3.5	0.1	21	45	107	131	101	138	0.82
3	6	2.2e-05	0.13	12.8	0.1	22	44	136	158	130	162	0.89
4	6	0.00038	2.2	8.8	0.2	21	45	163	187	158	193	0.89
5	6	0.00037	2.1	8.9	0.6	20	45	193	218	186	222	0.84
6	6	0.00032	1.8	9.1	0.1	18	46	219	247	218	251	0.89

Coding Sequence: ATGTCAACAGATATCAAGATACCAGATAATTTCCAAGAAGAACTAAAAAAATCAAAAGTCCAAATAAAAAGATCCAAAAAATACGAGTGTGATTATTGCAAGCATAAATTTTCTCATAAAAACGCTCTACTTGTTCACATCAACAAACATATGACCACAAAATACAGATGTGAGATCTGTTCAAAAAGTTACATCTCAAAAGAGGGCCTGTCTCTTCACACAGCTCGGCATACAGGCGACATGCCCtacgagtgtgaaatTTGTGCTTCTAAATTCGGGGTCAAATTTACTTACGACAATCACATGCGAATCCACAACGGCGAAAAGCCCTTCGCTTGTAACGTTTGTTCCTCGAAGTTCCGCGAAAAAAGCCAGCTGACCGTCCACCAGCGGATTCACTCAGGTGACAAGCCCTACACTTGTAACTTTTGCTCAGCGAAGTTTCGTCACAGTGGGAACTTGAAGGCTCACATTAGAACTCACACCAACGAGCGGCCTTTCAGTTGCGAAAAATGCTCCGCAAAATTCCGGGATCCTTCGACCCTAAGGAGGCACAAGCAAATTCACAGTGGAGAAAAAAGAGAAAAACGGTATTCTTGTGAAATTTGCTCCTGCAAACTTAGAGATAGTTACAATTTGAAAATTCACATACGCAGACATACTGGAGAGCGGCCTTTTGCTTGTCAAATTTGCTTCTTGAAATTCATCGAAAAGCGCTCGTTGAACAAACATATGAAAATTCATCAAAAGAAAATTAAGGAAGAAAAATTGTGA
Protein Sequence: MSTDIKIPDNFQEELKKSKVQIKRSKKYECDYCKHKFSHKNALLVHINKHMTTKYRCEICSKSYISKEGLSLHTARHTGDMPYECEICASKFGVKFTYDNHMRIHNGEKPFACNVCSSKFREKSQLTVHQRIHSGDKPYTCNFCSAKFRHSGNLKAHIRTHTNERPFSCEKCSAKFRDPSTLRRHKQIHSGEKREKRYSCEICSCKLRDSYNLKIHIRRHTGERPFACQICFLKFIEKRSLNKHMKIHQKKIKEEKL

Sequence clustering based on sequence similarity using MMseqs2