Cmar008223.1
Basic Information
- Insect
- Clunio marinus
- Gene Symbol
- PAX6
- Assembly
- GCA_900005825.1
- Location
- CVRI01000005.1:76290-88577[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 4.3e-73 1e-69 232.5 0.7 1 125 20 144 20 144 0.99 2 2 1.1 2.6e+03 -1.5 0.0 76 113 194 231 187 238 0.75
Sequence Information
- Coding Sequence
- ATGCATGGACATGCAACAGCCATCGGTCAAACGTCGCTTTTTGGATGCTCGTCAGCAGGCCATAGCGGAATCAATCAATTGGGCGGCGTATACGTCAATGGTCGTCCACTGCCCGACTCGACGCgacaaaaaattgttgagcTCGCTCATTCGGGAGCGAGACCTTGTGATATTTCCCGCATATTACAGGTTTCGAATGGATGTGTTAGTAAAATATTAGGCAGATATTACGAAACCGGCTCGATAAAACCGCGAGCGATTGGTGGATCAAAGCCGCGAGTTGCTACTCAAAATGTAGTCAATAAGATAGCAGATTATAAACGAGAATGTCCCAGTATATTCGCTTGGGAGATTCGTGATCGGTTGTTGTCTGAAGCTGTTTGCAATAGTGATAATATACCAAGTGTTTCATCGATAAATCGAGTTCTAAGAAATCTGGCCTCACAAAAGGAACAACAATCAGTGCCGAGTGATTCCGTCTATGACAAGCTTCGAATGTTCAATGGACAGTCAGGTGGATGGGCCTGGTATCCAACAAGTAATACCGCACCAGCGCACCTCTCGCTACCTCCAACACCAACGTCAGCACAACTTAGTGGGCAATTGACAAGAGATGAATTGCAAAAACGTGATTTATTTTCCGTCGACATTCAACAATCGAGTCTTCACGAGAGCACTTCAGATGGCAATTCCGAACACAATTCATCGGGTGACGAGGACTCGCAGATGCGTCTTAGACTGAAACGAAAACTACAACGAAATCGAACATCTTTCACCAACGAACAGATTGATAGTCTTGAGAAAGAATTTGAGAGAACGCACTATCCCGATGTCTTTGCTCGGGAACGATTAGCTGAGAAAATAGGATTACCCGAGGCAAGAATTCAGGTTTGGTTCTCGAATCGACGTGCAAAATGGAGACGTGAAGAGAAACTTCGTACTCAACGAAGATCAGTAGATCATGTGAGTGGAGGTGGTGGTGCTGGAAATGGAAGTTCGAATAATAATGGAAGTGGAAATACCGGAAGCAATGGTAGTGCAAATATAGGCAACACTAATTCAGTCAGCCCACCAGTGCCAACAACACCAAGGATACCTTTAAACTCGGGATTTAATTCAATGTATGCTTCAATTCCACAACCGATTGCGACAATGGCTGAGAACTACAgtgCAATGCCGCCATCTTTAGGCTCGATGACGTCACAATGTTTACAGCAACGTGACGGCTATCCGTACATGTTCACCGATCCATTACATTCACTGAGTAGTCCCTACAGTACACATCCATCGCGCACTGCATGCAACCCAACAGCAGCTCATCAGCAATCACATTACAGCACGTCAAATGGTGGCTCAGCTACAGGTGTCATAACTGCAGGAGTTTCTGTTCCAATACAAATTCCATCTCAAGGTTCTGAACTTGGTACAAACTATTGGCCGCGACTTCAGTGA
- Protein Sequence
- MHGHATAIGQTSLFGCSSAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATQNVVNKIADYKRECPSIFAWEIRDRLLSEAVCNSDNIPSVSSINRVLRNLASQKEQQSVPSDSVYDKLRMFNGQSGGWAWYPTSNTAPAHLSLPPTPTSAQLSGQLTRDELQKRDLFSVDIQQSSLHESTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFTNEQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRTQRRSVDHVSGGGGAGNGSSNNNGSGNTGSNGSANIGNTNSVSPPVPTTPRIPLNSGFNSMYASIPQPIATMAENYSAMPPSLGSMTSQCLQQRDGYPYMFTDPLHSLSSPYSTHPSRTACNPTAAHQQSHYSTSNGGSATGVITAGVSVPIQIPSQGSELGTNYWPRLQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00346565; iTF_00320429; iTF_00320549; iTF_01257075; iTF_01256945; iTF_01160309; iTF_01160421; iTF_01249051; iTF_01248935; iTF_01352448; iTF_01352597;
- 90% Identity
- iTF_01257075;
- 80% Identity
- iTF_00346565;