Cten014483.1
Basic Information
- Insect
- Chironomus tentans
- Gene Symbol
- PAX6
- Assembly
- GCA_963573255.1
- Location
- OY754304.1:45755939-45772029[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5.2e-73 9e-70 232.6 0.6 1 125 23 147 23 147 0.99 2 2 4.4 7.6e+03 -3.0 0.0 91 113 212 234 197 240 0.77
Sequence Information
- Coding Sequence
- ATGCATGACAAAATGCATGGACATGCAGCGATCGGTCAAACATCACTGTTCGGATGCTCATCCGCTGGTCATAGTGGCATCAATCAGCTGGGCGGTGTATATGTTAATGGTCGACCACTGCCAGACTCAACtagacaaaaaattgttgaattagCTCATTCAGGGGCCAGACCTTGTGATATTTCACGCATATTACAGGTTTCGAATGGATGTGTTAGCAAAATATTAGGAAGatatTATGAAACCGGTTCAATAAAGCCACGAGCTATTGGCGGATCAAAGCCGAGAGTTGCGACAGCAAATGTTGTGTCTAAAATTGCTGATTACAAACGTGAATGTCCGTCGATATTCGCATGGGAAATCCGTGATCGATTGTTATCGGATGGTGTATGCAATAGTGATAATATCCCAAGCGTTTCATCAATAAATCGGGTACTGAGGAATTTAGCATCACAGAAAGAGCAACAATCGTCACAAAGTGACTCCGTCTATGATAAACTTCGAATGTTTAATGGTCAATCAGGTGGATGGGCATGGTATCCGACAAGTAACACAGCACCAACACACCTAACATTACCTCCAACACCTACATCAGCACAACTCAGTGGACCATTGACGAGAGATGAGTTACAAAAGCGTGATTTATTTTCCGTCGATATTCAGCAATCGAGTCTACACGAGAGCACATCAGACGGCAATTCAGAGCATAATTCATCCGGTGATGAAGATTCACAGATGCGCTTACgactgaaaagaaaattacaaCGAAATCGTACATCGTTCACCAACGAGCAGATTGACAGTCTCGAAAAAGAATTCGAGAGAACGCACTATCCTGATGTCTTTGCAAGAGAACGATTAGCTGAGAAAATAGGATTACCCGAGGCAAGAATTCAGgTATGGTTTTCAAATCGTCGCGCGAAATGGAGACGAGAAGAGAAGTTAAGAACACAAAGACGTTCGGTGGATCATGTGAGTGGCGGCGGAAATGGTGGAACtccaaataataataataacaataacaatactaataacaataataattcgGGTAATGGAAATGCTGGAAGTAATGGCAGCGCAAATGTAGGAAATACAAACTCAGTCAGCCCACCAGTGCCAACAACACCGAGAATACCTTTAAATTCTGGTTTCAATTCAATGTATGCTTCGATTCCACAACCCATAGCAACAATGGCTGAAAGTTATagTGCAATGCCACCAACACTGGGCTCCATGACATCGACATGTTTGCAGCAACGTGATGGCTACCCATACATGTTTACCGATCCACTCCATTCGCTGAGTAGCCCATACAGTTCGTCACGGTCAAGTTGCACACCAACTGCCGCACATCAACAACCTCCATCACACAATTACAGTACAAATGGAAGTGCAAGTACAGGTGTCATTACAGCTGGTGTAAGCGTTCCAGTACAAATCGGATCACAAGACAGTTCTGGTCTTGGTACAAACTACTGGCCACGCCTTCAGTGA
- Protein Sequence
- MHDKMHGHAAIGQTSLFGCSSAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATANVVSKIADYKRECPSIFAWEIRDRLLSDGVCNSDNIPSVSSINRVLRNLASQKEQQSSQSDSVYDKLRMFNGQSGGWAWYPTSNTAPTHLTLPPTPTSAQLSGPLTRDELQKRDLFSVDIQQSSLHESTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFTNEQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRTQRRSVDHVSGGGNGGTPNNNNNNNNTNNNNNSGNGNAGSNGSANVGNTNSVSPPVPTTPRIPLNSGFNSMYASIPQPIATMAESYSAMPPTLGSMTSTCLQQRDGYPYMFTDPLHSLSSPYSSSRSSCTPTAAHQQPPSHNYSTNGSASTGVITAGVSVPVQIGSQDSSGLGTNYWPRLQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00346684;
- 90% Identity
- iTF_00320429;
- 80% Identity
- iTF_00320429;