Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.2e-23 4.4e-20 71.1 0.0 1 74 9 79 9 82 0.93

2 2 5e-05 0.1 12.3 0.0 29 76 168 224 143 225 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.2e-23	4.4e-20	71.1	0.0	1	74	9	79	9	82	0.93
2	2	5e-05	0.1	12.3	0.0	29	76	168	224	143	225	0.86

Coding Sequence: atgcaaatgaATCCTAGCGTTACCATTGAACGCAAACGCGTTGATTGCAGTGCCTTGCCTAAGGGCTGGCAACGTGAAGAGGTGCTTAGAAAGTCGGGCATTACTGCAGGTGCGGGCAAAGTCGACGTCTTTTATTATAGTCCTACAGGCAAGAAAATAGAAACCAAACCACAATTAGCACGCCAATTGGGCGATTCTTTTGATATAAGCAGCTTTGATTTCCAAACTGgcaaaatgctgcaacatCATTTGCCGTCGCCATCTATATCACTTTATCGCTGCAATGCAGCAGGCGCCATTATTGGTAGCACTGGCTCCGGCAGCGCCGCCAATGCGCTAAAACGCAAATATAGAGCGCAAGGTCAAGGTAGCAACAGTGTCAATACCAGTGGTCTTGCAGAAACGTCTACGAGTACGCCAGCAacgtcaacagcagcagcagcagcatcttcagcggcagcagcaaatctacgccaacaacaacttgaaTTCAGTCGCACGCTACGTACAGATGTCTCACTGGTGCCGCCCATACGCCAAACCGCATCCATATTCAAGCAGCCCGTCACTGTGGTGCGTAACCATGAGCACAGCAAGGTTAAGCATGTGGCCGCAAATGGTGTGCAGGAGAAACccaaacaagttttttgggaaaaacgTCTTGAGCGCTTGCGTGCTTGTCATGATACTGGCGAAGAGCTTGACGACATATCATTGCCCAAAACTATACGAACTGTAGGACCAAATGTTAACGAGCAGACTTTGCTACAATCCGTAGCGACAGCGTTACATGTGCTCAGTGCCGGCGTGCATGGCCAAACCTTAACAAAAGCTGAACTGACTAAAAATACAATGGCTTTTATGAATCCAGAACAGCCGCTAATGCATGCAGTTATTATATCCGAGGATGATATACGCAAGCAAGAGGACCGTGTTAGTGTGGCGCGACGTAAACTGCAGGATGCGTTGAAAACTTAA
Protein Sequence: MQMNPSVTIERKRVDCSALPKGWQREEVLRKSGITAGAGKVDVFYYSPTGKKIETKPQLARQLGDSFDISSFDFQTGKMLQHHLPSPSISLYRCNAAGAIIGSTGSGSAANALKRKYRAQGQGSNSVNTSGLAETSTSTPATSTAAAAASSAAAANLRQQQLEFSRTLRTDVSLVPPIRQTASIFKQPVTVVRNHEHSKVKHVAANGVQEKPKQVFWEKRLERLRACHDTGEELDDISLPKTIRTVGPNVNEQTLLQSVATALHVLSAGVHGQTLTKAELTKNTMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2