Basic Information

Gene Symbol
MBD2
Assembly
GCA_035041775.1
Location
JAWNKW010000189.1:2763047-2764556[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.4e-23 1.7e-20 72.5 0.0 1 74 9 79 9 82 0.93
2 2 0.00014 0.17 11.6 0.0 26 75 159 217 137 219 0.83

Sequence Information

Coding Sequence
ATGCAAATGAATCCTAGCGTCACAATTGAGCGCAAACGCGTCGATTGCAGCGCATTGCCCAAAGGCTGGCAACGCGAAGAGGTGCTAAGAAAGTCGGGTATCACAGCGGGTGCGGGCAAAGTCGATGTCTTTTATTACAGTCCAACAGGCaagaaaattgaaagcaaaccACAATTGGCTCGCCAATTGGGCGATTCTTTTGATATAAGCAGCTTTGATTTCCAAACTGGCAAAATGCTGCATCATCATTTGCCATCACCATCTATATCACTTTATCGCTGCAATGCAGCTGGCGCAATTATCAATAGCACTGGTTCTGGCAGCGCAGCAAATGCTCTAAAACGAAAATTTAGAGCCCAAGGCCAAGGCAGCAACTGTGGGCTTACACCAACTTCAACAGTGTCGACATCAACGAtggcaacaacggcaacagcagcggcagcagcaaatcTACGCCAGCAACAACTTGAATTCAGTCGCGCCCTACGCACTGATGTCTCACTGGTACCGCCCATACGACAAACCGCATCCATATTTAAGCAGCCCGTCACTGTGGTGCGTAATCATGAGCCCTGCAAGGTTAAGCACGATGCCAAGCATGGGGCGCAAGAGAAACCCAAACAGGCTTTTTGGGAAAAACGTCTAGAGCGCTTGCGCGCTTGCCATGACACTGGCGAGGAGCTCGACGAGATATCTCTACCCAAAACCATACGCACTGTTGGTCCTAATGTAAACGAACAGACTCTTCTGCAATCTGTAGCCACAGCGCTGCATGTACTCAATGCCGGCGTGCATGGGCAGACCTTAACAAAGGCTGAACTGACAAAGAATGCCATGGCATTTATGAATCCCGAGCAGCCACTTATGCATGCAGTTATCATATCCGAGGATGATATACGCAAGCAAGAGGATCGCGTTAGTGTGGCGCGACGAAAACTACAAGATGCGCTGAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDCSALPKGWQREEVLRKSGITAGAGKVDVFYYSPTGKKIESKPQLARQLGDSFDISSFDFQTGKMLHHHLPSPSISLYRCNAAGAIINSTGSGSAANALKRKFRAQGQGSNCGLTPTSTVSTSTMATTATAAAAANLRQQQLEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPCKVKHDAKHGAQEKPKQAFWEKRLERLRACHDTGEELDEISLPKTIRTVGPNVNEQTLLQSVATALHVLNAGVHGQTLTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVSVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00339142;
90% Identity
-
80% Identity
-