Basic Information

Gene Symbol
L
Assembly
GCA_018150985.1
Location
JAECWU010000379.1:5991419-6003794[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 9.6e-06 0.00077 19.8 2.9 1 23 169 191 169 191 0.98
2 18 0.33 26 5.6 6.2 1 23 197 219 197 219 0.97
3 18 1.6e-07 1.3e-05 25.4 3.2 1 23 225 247 225 247 0.99
4 18 1.2e-05 0.00094 19.6 0.4 1 23 253 275 253 275 0.99
5 18 0.11 9 7.0 0.1 2 23 340 363 339 363 0.90
6 18 0.0036 0.29 11.7 0.2 2 23 383 405 382 405 0.95
7 18 0.058 4.7 7.9 0.7 1 23 485 507 485 507 0.97
8 18 0.0072 0.58 10.8 0.0 2 23 515 536 514 536 0.91
9 18 0.00094 0.075 13.6 0.2 1 23 544 568 544 568 0.93
10 18 6.1 4.9e+02 1.6 1.7 2 23 604 626 603 626 0.91
11 18 0.0024 0.19 12.3 1.1 1 23 679 702 679 702 0.97
12 18 0.55 44 4.9 1.2 1 23 872 896 872 896 0.94
13 18 0.0023 0.19 12.3 3.8 2 23 905 927 904 927 0.96
14 18 0.038 3 8.5 0.1 1 23 933 955 933 955 0.92
15 18 0.041 3.3 8.4 0.2 2 23 963 984 962 984 0.96
16 18 0.44 35 5.2 0.3 2 23 1105 1126 1105 1126 0.94
17 18 0.0097 0.77 10.4 0.0 1 23 1136 1158 1136 1158 0.96
18 18 0.45 36 5.2 1.5 1 23 1165 1187 1165 1187 0.97

Sequence Information

Coding Sequence
ATGATGGCTTTAAAAATGTTATATCGTGGTCCCAGTTCACGTTTAGAAAATTTAATTGAAAAAATTCAAGCGACCAGGGAAATAACAAATAACGATATGTACTCCACGCATACCTCTTCCAGCTATTCGCCTTCCATATCAGATGGCACGCTTACGCCCAATTCGCATTTGCCACAAACAGAGCAGGACACGGCAAGTGCAGAGCTTAAAACCAATGGCGAAGCTGTTGCTGCTGCTGCAGGCGGAGATGCCGAGCTGTTACCCGTGGCTGTCAAGGCCAAACGCCCTGCGCACTTAACGCATCATCATCATCATTACCATCATCAGCAGGCGCTAAAAATTGCCAACAAGTTGCGCAAAATCAATAAGGAAGCCAAGCTACAAGCGGCTGGCAGTGGCGGCGCTGGAGGAGCTGCTGGTGCCGCTTCCACTGGCACGACCAGCAGCGCCACAAAGTTTAATAAGTTGACAGGCGAGGGCATTAAAAGCAGAAGCGACGGTTCCTATCAGTGTCAGTTTTGTGATAAATCATTTCCGCGACTCGGCTACTTGAAACATCATGTGCAGAGCCATGCCGAACATCTACCGTTTAAGTGTGAGTACTGCGCCAAGTTGTTCAAGCACAAACGCTCACGTGATCGCCATAAGAAATTGCACACAAATGAGAGGAACTACAAGTGTCCGCATTGTGAGGCCGCATTCTCCAGAAGCGATCATCTGAAGATTCACATGAAAACCCACGACATCCAAAAGCCCTTTCAGTGCAGCATGTGCAACCGTGGCTACAACACCGCCGCTGCTCTTACCTCCCACATGCAAAAGCACAAGAAGAATGCAGCCATACTGGCTGCCGGCGGCAATCCCAACGCCCTCAACTACAGTCCACGTTCCACTGGCTCCGCCTCAAGCAACGGCAGTCTAAACAAACGACGCTATGCGCTAGCCATGGCTTCCGACAGCAGTCCCAGCCGCTTGGAATTCCCTAAACGTGCGCGTGCCACACCCACACCATTGCTGCGTTGCAGCTACTGCCCCAAGGCGGAGTTTAGTAGTTTGGAGCAGCTAAACGGGCATCTGCAGAGCGCGCACGAGCAAGTGCAGCAAGCGAAGCCATCAGTTACTAACGCAGAGGATGGCTTTCAGCTAAGCTGCGAATACTGCACCATGAAGTTTGGCAATATAGCTGGTCTATTCCAGCACATGAGAGCCACGCACATGGATCGCCTAAGCAGTCCTAATTCATATTATGAGCACTTTAATCGTTTGGCCACCGCGGGCACTTTTAGTCCACGTTTGGCTTTAGAACAGCTGCCCAAGATTAAGCAGGACTTGCACAGTCCACAGCCGCCGCTAAAAACTCACGCAGAAGAGGAACCTACCGATTTGAGCAGCAACAAAAGACGCAGCGTGGAGTTGGAAACAGCAACAGCAGCGCCTGCAGCTCCAGGCATCTTTTTTTGCAATCAATGCAATGCAGGTCTGCCGGATTTTGAAAGCTTCCGTAATCATTTAAAGTCACATATATCCGAGGGTCTGCAGCTGGTGTGTCCACATTGCGGTATTACTTTACCGGATCAGCCGGAGTATGAGCGTCATGTTGTAGCCCACTTTTTGATAACCAACTCGGAGTACAACTGCAGCGCTAGCTGTAGCAAATCCTTTGCCAAGGCGGAGGAGCTACAAAAGCATTTACTGGCCGAACATGTGGTGACCATGTTGAAGTGTGCGTTATGCTCGGAGCTCTGTGAATCCCAGGTGGCCATGCAGCTGCACTTTGCCTGTACACATACCCAAGAAACCAAACTGTTGCGCTGCAGCGCCTGCATGGAGCTGTTCCGTAATGAGACGGACTTTCATGTGCACGTCAAGACGCGTCACCAGCTGGCCAATGGCATGTTAGCCGCCGCCTCTGCTTCCGCCAATGTGGCCAATGCCGGTTCAATGCCAGCTAGTCCCTTGCAGTGCATGTTCTGTCGTGTGGTGTGCTCCTCGGAGCTGGAAATGCATTTCCATTTGGCTGCACATGCTCGCCAATTTCGTTGTCCCTCCTGCCCGGAAACATTTCATGTGGAATTTCTACTGGATCGTCATATGCAAAGTCAGCATGGTGGCGCCTTGGAGGAGCGCACTGCCAGCGATAAGGACAGCTATGAGGAGACAGCAGCTGTTTCCGTCGCTAATGCCAACGCCTTAAGTCCCATGAACAGTCTTTATGTAAATGCTTTGTTTGGTGGCAAGCCGCACTTGCTGCCTAGCCTGGGCGCGTCCAGCGCCAATACCAATAACAACAGCAGCATTTTAGACTACAATGTGGCCTTTGCGGCGGCTCAGTTGCAGCACAAGGGTCTGTTTGCACCGCCGGCACCCACAGCCAGCTCCAAGTTCTATAGCCCGCTGCAAGTGGATACCAGCGCCTTGAAGCCACAGGCTGCAGCGCATCCTGCGCTTATGTATGGTCTAAGTCAGCGTTATTTCGACACTAATCGCGCCTTGATGGAGATGTATGCAGCGCAGCAGAGCAAGAGTTCCAACTACTTTGCGCCCAGTCCTAAGGCAGCGCAGGAAACAAGCGGCAGAGGCTCCAACGAAGTTGCTCCCCCTCCCACCAATAGCTACAGCTGCGGCATGTGCGAACGTCAGGATTTTCGCAGCGAAACGGAGCTGCATTCACATCGTAAGATTGCGCATAATATGAAAACTGGCGTCAGCTTGCGTTGTGCCTATTGTGCGGGTAACTTCAAATCCCGCAGCGAGCTGGAGCATCATATGAAAACCTGTCACAACTCCACGGGCAAGCACAAGTGTCTGATCTGTGATGAGGTGTTTCCTTCACCTGCCATACTAGCGGAGCATAAGCTGCAGCACTCCAAGGTGGGTCAATCTGGCAAGTGTTCGCATTGTGGTCAGCCTTTGGCTGATGTGGCTGCTTTCAAGTCCCATTTGTCTGAGCATGGTCAGAATGCTACAGCGAATGGTGGCGGCAGCAGCGCTACGCCACCGGTGCAGTGCATCTGCTGTCGTCAGACTTTACACTCGGACTTTGAGATAAGCTTACATGCCAAGTTTCATACGAAATCGGGCAACAGTCTGCAAGAGCCGGTATGCGCGCTCTGCTTAGAACCTTTGGAGTGCTCCTCCGGCAACAACAACAATGGCAATAATGGCGAACCACCTGCTCCTGCCAAGGTGTGCGACAAATGCTGCCGCAAACATAATCTCAATCCAAAACAACGCAAATCCCAGACCGAAACACATTATGAATTGCCGCCGCCAAGTAGTGCTGCCTCCGCCAGCTCTAGCTATACAGAAAACCGCTGTAATTTGTGTAAGATGATACTGCCACATGCAGCTAAGCTGCAGGAGCATCTGGTGGAGCATACCTTTGCAGGCACTGAGGAACGTGGATTTAACTGTTATATATGTTCAGCTGTTTTCACTGCGCCCGCTGGTTTGCTTAATCATATGGCAGAGCATGGCCAGAATGCCAAACCTTATGATTGCAATTTGTGCGCGGATAAGTTCTACTTTCGTGCTGAGTTAGATCATCATCAGCGGGAACATGAGCTTAGACCAGCCGCAGCCACACGTGCGCTAACCTTGCCCAAACAAGAGCCACTAACTCAACCGGAAACGCCACCCAGCCGCGATAGTCCCACTACTGTTAAACAGGAGCTCTATGAAACAGAAAATGAGTGTAGCCCCGCTGCGGTACCCATACAGGAAGAGGAGGAGTACATAGAGGTGGAACAAATGCCGCATGAAACGCGCACAGCCGAAACTATAGGTAATACAGAACGTTCTAGCAGTAGCGCTTAA
Protein Sequence
MMALKMLYRGPSSRLENLIEKIQATREITNNDMYSTHTSSSYSPSISDGTLTPNSHLPQTEQDTASAELKTNGEAVAAAAGGDAELLPVAVKAKRPAHLTHHHHHYHHQQALKIANKLRKINKEAKLQAAGSGGAGGAAGAASTGTTSSATKFNKLTGEGIKSRSDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASSNGSLNKRRYALAMASDSSPSRLEFPKRARATPTPLLRCSYCPKAEFSSLEQLNGHLQSAHEQVQQAKPSVTNAEDGFQLSCEYCTMKFGNIAGLFQHMRATHMDRLSSPNSYYEHFNRLATAGTFSPRLALEQLPKIKQDLHSPQPPLKTHAEEEPTDLSSNKRRSVELETATAAPAAPGIFFCNQCNAGLPDFESFRNHLKSHISEGLQLVCPHCGITLPDQPEYERHVVAHFLITNSEYNCSASCSKSFAKAEELQKHLLAEHVVTMLKCALCSELCESQVAMQLHFACTHTQETKLLRCSACMELFRNETDFHVHVKTRHQLANGMLAAASASANVANAGSMPASPLQCMFCRVVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGALEERTASDKDSYEETAAVSVANANALSPMNSLYVNALFGGKPHLLPSLGASSANTNNNSSILDYNVAFAAAQLQHKGLFAPPAPTASSKFYSPLQVDTSALKPQAAAHPALMYGLSQRYFDTNRALMEMYAAQQSKSSNYFAPSPKAAQETSGRGSNEVAPPPTNSYSCGMCERQDFRSETELHSHRKIAHNMKTGVSLRCAYCAGNFKSRSELEHHMKTCHNSTGKHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLADVAAFKSHLSEHGQNATANGGGSSATPPVQCICCRQTLHSDFEISLHAKFHTKSGNSLQEPVCALCLEPLECSSGNNNNGNNGEPPAPAKVCDKCCRKHNLNPKQRKSQTETHYELPPPSSAASASSSYTENRCNLCKMILPHAAKLQEHLVEHTFAGTEERGFNCYICSAVFTAPAGLLNHMAEHGQNAKPYDCNLCADKFYFRAELDHHQREHELRPAAATRALTLPKQEPLTQPETPPSRDSPTTVKQELYETENECSPAAVPIQEEEEYIEVEQMPHETRTAETIGNTERSSSSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00337012;
90% Identity
iTF_00339377;
80% Identity
-